- Regulatory Role of Human AP-Endonuclease (APE1/Ref-1) in YB-1-Mediated Activation of the Multidrug Resistance Gene MDR1
[作者:Chattopadhyay, R; Das, S; Maiti, AK; Boldogh, I; Xie, JW; Hazra, TK; Kohno, K; Mitra, S; Bhakat, KK,期刊:Molecular and Cellular Biology, 页码:7066-7080 , 文章类型: Article,,卷期:2008年28-23]
- Human AP-endonuclease (APE1/Ref-1), a central enzyme involved in the repair of oxidative base damage and DNA strand breaks, has a second activity as a transcriptional regulator that binds to several trans-acting factors....
- Hypoxia-Associated Factor, a Novel E3-Ubiquitin Ligase, Binds and Ubiquitinates Hypoxia-Inducible Factor 1 alpha, Leading to Its Oxygen-Independent Degradation
[作者:Koh, MY; Darnay, BG; Powis, G,期刊:Molecular and Cellular Biology, 页码:7081-7095 , 文章类型: Article,,卷期:2008年28-23]
- The hypoxia-inducible factor 1 alpha (HIF-1 alpha) is the master regulator of the cellular response to hypoxia. A key regulator of HIF-1 alpha is von Hippel-Lindau protein (pVHL), which mediates the oxygen-dependent, pro...
- Ras Is Required for the Cyclic AMP-Dependent Activation of Rap1 via Epac2
[作者:Liu, C; Takahashi, M; Li, YP; Song, S; Dillon, TJ; Shinde, U; Stork, PJS,期刊:Molecular and Cellular Biology, 页码:7109-7125 , 文章类型: Article,,卷期:2008年28-23]
- Exchange proteins activated by cAMP (cyclic AMP) 2 (Epac2) is a guanine nucleotide exchange factor for Rap1, a small G protein involved in many cellular functions, including cell adhesion, differentiation, and exocytosis...
- Acetylation of Rsc4p by Gcn5p Is Essential in the Absence of Histone H3 Acetylation
[作者:Choi, JK; Grimes, DE; Rowe, KM; Howe, LJ,期刊:Molecular and Cellular Biology, 页码:6967-6972 , 文章类型: Article,,卷期:2008年28-23]
- Rsc4p, a subunit of the RSC chromatin-remodeling complex, is acetylated at lysine 25 by Gcn5p, a well-characterized histone acetyltransferase (HAT). Mutation of lysine 25 does not result in a significant growth defect, a...
- Balance between Distinct HP1 Family Proteins Controls Heterochromatin Assembly in Fission Yeast
[作者:Sadaie, M; Kawaguchi, R; Ohtani, Y; Arisaka, F; Tanaka, K; Shirahige, K; Nakayama, J,期刊:Molecular and Cellular Biology, 页码:6973-6988 , 文章类型: Article,,卷期:2008年28-23]
- Heterochromatin protein 1 ( HP1) is a conserved chromosomal protein with important roles in chromatin packaging and gene silencing. In fission yeast, two HP1 family proteins, Swi6 and Chp2, are involved in transcriptiona...
- PML Activates Transcription by Protecting HIPK2 and p300 from SCFFbx3-Mediated Degradation
[作者:Shima, Y; Shima, T; Chiba, T; Irimura, T; Pandolfi, PP; Kitabayashi, I,期刊:Molecular and Cellular Biology, 页码:7126-7138 , 文章类型: Article,,卷期:2008年28-23]
- PML, a nuclear protein, interacts with several transcription factors and their coactivators, such as HIPK2 and p300, resulting in the activation of transcription. Although PML is thought to achieve transcription activati...
- Glyceraldehyde-3-Phosphate Dehydrogenase Regulates Endothelin-1 Expression by a Novel, Redox-Sensitive Mechanism Involving mRNA Stability
[作者:Rodriguez-Pascual, F; Redondo-Horcajo, M; Magan-Marchal, N; Lagares, D; Martinez-Ruiz, A; Kleinert, H; Lamas, S,期刊:Molecular and Cellular Biology, 页码:7139-7155 , 文章类型: Article,,卷期:2008年28-23]
- The regulation of the synthesis of the endothelial-derived vasoconstrictor endothelin-1 (ET-1) is a complex process encompassing transcriptional as well as mRNA stability mechanisms. We have described recently the existe...
- Control of Cellular GADD34 Levels by the 26S Proteasome
[作者:Brush, MH; Shenolikar, S,期刊:Molecular and Cellular Biology, 页码:6989-7000 , 文章类型: Article,,卷期:2008年28-23]
- GADD34, the product of a growth arrest and DNA damage-inducible gene, is expressed at low levels in unstressed cells. In response to stress, the cellular content of GADD34 protein increases and, on termination of stress,...
- Redundant Roles of SMAD2 and SMAD3 in Ovarian Granulosa Cells In Vivo
[作者:Li, QL; Pangas, SA; Jorgez, CJ; Graff, JM; Weinstein, M; Matzuk, MM,期刊:Molecular and Cellular Biology, 页码:7001-7011 , 文章类型: Article,,卷期:2008年28-23]
- Transforming growth factor beta (TGF-beta) superfamily members are critical in maintaining cell growth and differentiation in the ovary. Although signaling of activins, TGF-beta s, growth differentiation factor 9, and no...
- Superfluous Role of Mammalian Septins 3 and 5 in Neuronal Development and Synaptic Transmission
[作者:Tsang, CW; Fedchyshyn, M; Harrison, J; Xie, H; Xue, J; Robinson, PJ; Wang, LY; Trimble, WS,期刊:Molecular and Cellular Biology, 页码:7012-7029 , 文章类型: Article,,卷期:2008年28-23]
- The septin family of GTPases, first identified for their roles in cell division, are also expressed in postmitotic tissues. SEPT3 (G-septin) and SEPT5 (CDCrel-1) are highly expressed in neurons, enriched in presynaptic t...
- Role of the Caenorhabditis elegans Shc Adaptor Protein in the c-Jun N-Terminal Kinase Signaling Pathway
[作者:Mizuno, T; Fujiki, K; Sasakawa, A; Hisamoto, N; Matsumoto, K,期刊:Molecular and Cellular Biology, 页码:7041-7049 , 文章类型: Article,,卷期:2008年28-23]
- Mitogen-activated protein kinases (MAPKs) are integral to the mechanisms by which cells respond to physiological stimuli and a wide variety of environmental stresses. In Caenorhabditis elegans, the stress response is con...
- Nucleophosmin Serves as a Rate-Limiting Nuclear Export Chaperone for the Mammalian Ribosome
[作者:Maggi, LB; Kuchenruether, M; Dadey, DYA; Schwope, RM; Grisendi, S; Townsend, RR; Pandolfi, PP; Weber, JD,期刊:Molecular and Cellular Biology, 页码:7050-7065 , 文章类型: Article,,卷期:2008年28-23]
- Nucleophosmin (NPM) (B23) is an essential protein in mouse development and cell growth; however, it has been assigned numerous roles in very diverse cellular processes. Here, we present a unified mechanism for NPM's role...
|