- Inhibition of glutaminyl cyclase attenuates cell migration modulated by monocyte chemoattractant proteins
[作者:Chen, YL; Huang, KF; Kuo, WC; Lo, YC; Lee, YM; Wang, AHJ,期刊:Biochemical Journal, 页码:403-412 , 文章类型: Article,,卷期:2012年442-2]
- QC (glutaminyl cyclase) catalyses the formation of N-terminal pGlu (pyroglutamate) in peptides and proteins. pGlu formation in chemoattractants may participate in the regulation of macrophage activation and migration. Ho...
- Oxidation of Met(1606) in von Willebrand factor is a risk factor for thrombotic and septic complications in chronic renal failure
[作者:De Filippis, V; Lancellotti, S; Maset, F; Spolaore, B; Pozzi, N; Gambaro, G; Oggianu, L; Calo, LA; De Cristofaro, R,期刊:Biochemical Journal, 页码:423-432 , 文章类型: Article,,卷期:2012年442-2]
- CKD (chronic kidney disease) is a life-threatening pathology, often requiring HD (haemodialysis) and characterized by high OS (oxidative stress), inflammation and perturbation of vascular endothelium. HD patients have in...
- Secreted CXCL12 (SDF-1) forms dimers under physiological conditions
[作者:Ray, P; Lewin, SA; Mihalko, LA; Lesher-Perez, SC; Takayama, S; Luker, KE; Luker, GD,期刊:Biochemical Journal, 页码:433-442 , 文章类型: Article,,卷期:2012年442-2]
- Chemokine CXCL12 (CXC chemokine ligand 12) signalling through CXCR (CXC chemokine receptor) 4 and CXCR7 has essential functions in development and underlies diseases including cancer, atherosclerosis and autoimmunity. Ch...
- Targeting of pro-apoptotic TLR adaptor SARM to mitochondria: definition of the critical region and residues in the signal sequence
[作者:Panneerselvam, P; Singh, LP; Ho, B; Chen, JZ; Ding, JL,期刊:Biochemical Journal, 页码:263-271 , 文章类型: Article,,卷期:2012年442-2]
- The fifth and the most well-conserved member of the TLR (Toll-like receptor) adaptor, SARM (sterile alpha- and HEAT/armadillo-motif-containing protein), has been reported to be an important mediator of apoptosis. However...
- Epidermal growth factor induces tumour marker AKR1B10 expression through activator protein-1 signalling in hepatocellular carcinoma cells
[作者:Liu, ZW; Yan, RL; Al-Salman, A; Shen, Y; Bu, YW; Ma, J; Luo, DX; Huang, CF; Jiang, YY; Wilber, A; Mo, YY; Huang, MC; Zhao, YP; Cao, DL,期刊:Biochemical Journal, 页码:273-282 , 文章类型: Article,,卷期:2012年442-2]
- AKR1B10 (aldo-keto reductase 1B10) is overexpressed in liver and lung cancer, and plays a critical role in tumour development and progression through promoting lipogenesis and eliminating cytotoxic carbonyls. AKR1B10 is ...
- An aspartate residue in the external vestibule of GLYT2 (glycine transporter 2) controls cation access and transport coupling
[作者:Perez-Siles, G; Nunez, E; Morreale, A; Jimenez, E; Leo-Macias, A; Pita, G; Cherubino, F; Sangaletti, R; Bossi, E; Ortiz, AR; Aragon, C; Lopez-Corcuera, B,期刊:Biochemical Journal, 页码:323-334 , 文章类型: Article,,卷期:2012年442-2]
- Synaptic glycine levels are controlled by GLYTs (glycine transporters). GLYT1 is the main regulator of synaptic glycine concentrations and catalyses Na+-Cl--glycine co-transport with a 2:1:1 stoichiometry. In contrast, n...
- Lactococcus lactis HemW (HemN) is a haem-binding protein with a putative role in haem trafficking
[作者:Abicht, HK; Martinez, J; Layer, G; Jahn, D; Solioz, M,期刊:Biochemical Journal, 页码:335-343 , 文章类型: Article,,卷期:2012年442-2]
- Lactococcus lactis cannot synthesize haem, but when supplied with haem, expresses a cytochrome bd oxidase. Apart from the cydAB structural genes for this oxidase, L. lactis features two additional genes, hemH and hemW (h...
- Progestins activate 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) in breast cancer cells
[作者:Novellasdemunt, L; Obach, M; Millan-Arino, L; Manzano, A; Ventura, F; Rosa, JL; Jordan, A; Navarro-Sabate, A; Bartrons, R,期刊:Biochemical Journal, 页码:345-356 , 文章类型: Article,,卷期:2012年442-2]
- PFKFB (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) catalyses the synthesis and degradation of Fru-2,6-P-2 (fructose-2,6-bisphosphate), a key modulator of glycolysis and gluconeogenesis. The PFKFB3 gene is exten...
- Plant cell walls to ethanol
[作者:Jordan, DB; Bowman, MJ; Braker, JD; Dien, BS; Hector, RE; Lee, CC; Mertens, JA; Wagschal, K,期刊:Biochemical Journal, 页码:241-252 , 文章类型: Review,,卷期:2012年442-2]
- Conversion of plant cell walls to ethanol constitutes second generation bioethanol production. The process consists of several steps: biomass selection/genetic modification, physiochemical pretreatment, enzymatic sacchar...
- Mesothelin enhances invasion of ovarian cancer by inducing MMP-7 through MAPK/ERK and JNK pathways
[作者:Chang, MC; Chen, CA; Chen, PJ; Chiang, YC; Chen, YL; Mao, TL; Lin, HW; Chiang, WHL; Cheng, WF,期刊:Biochemical Journal, 页码:293-302 , 文章类型: Article,,卷期:2012年442-2]
- Ovarian cancer has one of the highest mortalities in malignancies in women, but little is known of its tumour progression properties and there is still no effective molecule that can monitor its growth or therapeutic res...
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