- Physiologically Relevant Concentrations of NaCl and KCl Increase DNA Photocleavage by an N-Substituted 9-Aminomethylanthracene Dye
[作者:Terry, CA; Fernandez, MJ; Gude, L; Lorente, A; Grant, KB,期刊:Biochemistry, 页码:10375-10389 , 文章类型: Article,,卷期:2011年50-47]
- This paper describes the synthesis of a new 9-aminomethylanthracene dye N-substituted with a pyridinylpoly-amine side chain (4). The effects of NaCl and KCl on anthracene/DNA interactions were then studied, with the goal...
- Preparation of an Activated Rhodopsin/Transducin Complex Using a Constitutively Active Mutant of Rhodopsin
[作者:Xie, GF; D'Antona, AM; Edwards, PC; Fransen, M; Standfuss, J; Schertler, GFX; Oprian, DD,期刊:Biochemistry, 页码:10399-10407 , 文章类型: Article,,卷期:2011年50-47]
- The interaction of rhodopsin and transducin has been the focus of study for more than 30 years, but only recently have efforts to purify an activated complex in detergent solution materialized. These efforts have used na...
- Entropy-Driven Binding of Picomolar Transition State Analogue Inhibitors to Human 5 '-Methylthioadenosine Phosphorylase
[作者:Guan, R; Ho, MC; Brenowitz, M; Tyler, PC; Evans, GB; Almo, SC; Schramm, VL,期刊:Biochemistry, 页码:10408-10417 , 文章类型: Article,,卷期:2011年50-47]
- Human 5'-methylthioadenosine phosphorylase (MTAP) links the polyamine biosynthetic and S-adenosyl-L-2 methionine salvage pathways and is a target for anticancer drugs. p-Cl-PhT-DADMe-ImmA is a 10 pM, slow-onset tight-bin...
- Crystal Structures of Prethrombin-2 Reveal Alternative Conformations under Identical Solution Conditions and the Mechanism of Zymogen Activation
[作者:Pozzi, N; Chen, ZW; Zapata, F; Pelc, LA; Barranco-Medina, S; Di Cera, E,期刊:Biochemistry, 页码:10195-10202 , 文章类型: Article,,卷期:2011年50-47]
- Prethrombin-2 is the immediate zymogen precursor of the clotting enzyme thrombin, which is generated upon cleavage at R15 and separation of the A chain and catalytic B chain. The X-ray structure of prethrombin-2 determin...
- Reconstitution of CF IA from Overexpressed Subunits Reveals Stoichiometry and Provides Insights into Molecular Topology
[作者:Gordon, JMB; Shikov, S; Kuehner, JN; Liriano, M; Lee, E; Stafford, W; Poulsen, MB; Harrison, C; Moore, C; Bohm, A,期刊:Biochemistry, 页码:10203-10214 , 文章类型: Article,,卷期:2011年50-47]
- Yeast cleavage factor I (CF I) is an essential complex of five proteins that binds signal sequences at the 3' end of yeast mRNA. CF I is required for correct positioning of a larger protein complex, CPF, which contains t...
- Tuning a Polar Molecule for Selective Cytoplasmic Delivery by a pH (Low) Insertion Peptide
[作者:Wijesinghe, D; Engelman, DM; Andreev, OA; Reshetnyak, YK,期刊:Biochemistry, 页码:10215-10222 , 文章类型: Article,,卷期:2011年50-47]
- Drug molecules are typically hydrophobic and small in order to traverse membranes to reach cytoplasmic targets, but we have discovered that more polar molecules can be delivered across membranes using water-soluble, mode...
- Crystal Structure and Characterization of Particulate Methane Monooxygenase from Methylocystis species Strain M
[作者:Smith, SM; Rawat, S; Telser, J; Hoffman, BM; Stemmler, TL; Rosenzweig, AC,期刊:Biochemistry, 页码:10231-10240 , 文章类型: Article,,卷期:2011年50-47]
- Particulate methane monooxygenase (pMMO) is an integral membrane metalloenzyme that oxidizes methane to methanol in methanotrophic bacteria. Previous biochemical and structural studies of pMMO have focused on preparation...
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