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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共9条记录   PDGF-receptor beta-targeted adenovirus redirects gene transfer from hepatocytes to activated stellate cells [作者：Schoemaker, MH; Rots, MG; Beljaars, L; Ypma, AY; Jansen, PLM; Poelstra, K; Moshage, H; Haisma, HJ,期刊：Molecular Pharmaceutics, 页码：399-406 , 文章类型： Article，,卷期：2008年5-3] Chronic liver damage may lead to liver fibrosis. In this process, hepatic activated stellate cells are the key players. Thus, activated stellate cells are attractive targets for antifibrotic gene therapy. Recombinant, ad... iNOS gene silencing prevents inflammatory cytokine-induced beta-cell apoptosis [作者：Li, F; Mahato, RI,期刊：Molecular Pharmaceutics, 页码：407-417 , 文章类型： Article，,卷期：2008年5-3] Human islet transplantation has great potential as an effective means of treating insulin-dependent diabetes mellitus. Upregulation of inducible nitric oxide synthase (NOS) and subsequent product of radical nitric oxide ... Biophysical characterization of nanoparticle-endothelial model cell membrane interactions [作者：Peetla, C; Labhasetwar, V,期刊：Molecular Pharmaceutics, 页码：418-429 , 文章类型： Article，,卷期：2008年5-3] Understanding the biophysical interactions of nanoparticles (NPs) with cell membranes is critical for developing effective nanocarrier systems for drug delivery applications. We developed an endothelial model cell membra... Induced disorder in protein-ligand complexes as a drug-design strategy [作者：Crespo, A; Fernandez, A,期刊：Molecular Pharmaceutics, 页码：430-437 , 文章类型： Article，,卷期：2008年5-3] Protein associations are poorly understood from a chemical perspective. If the contrary were true, drug inhibitors would be routinely designed based on target structure. While enthalpy/ entropy balance is critical for af... The impact of molecular weight and PEG chain length on the systemic pharmacokinetics of PEGylated poly L-lysine dendrimers [作者：Kaminskas, LM; Boyd, BJ; Karellas, P; Krippner, GY; Lessene, R; Kelly, B; Porter, CJH,期刊：Molecular Pharmaceutics, 页码：449-463 , 文章类型： Article，,卷期：2008年5-3] The impact of PEGylation on the pharmacokinetics and biodistribution of H-3-labeled Poly L-lysine dendrimers has been investigated after intravenous administration to rats. The volumes of distribution, clearance and cons... Development of structure-lipid bilayer permeability relationships for peptide-like small organic molecules [作者：Cao, YC; Xiang, TX; Anderson, BD,期刊：Molecular Pharmaceutics, 页码：371-388 , 文章类型： Article，,卷期：2008年5-3] Computational methods to estimate passive membrane permeability coefficients of organic molecules, including peptides, would be valuable in understanding various biological processes associated with molecular transport a... Impact of pH on plasma protein binding in equilibrium dialysis [作者：Kochansky, CJ; McMasters, DR; Lu, P; Koeplinger, KA; Kerr, HH; Shou, M; Korzekwa, KR,期刊：Molecular Pharmaceutics, 页码：438-448 , 文章类型： Article，,卷期：2008年5-3] Many pharmacokinetic analyses require unbound plasma concentrations, including prediction of clearance, volume of distribution, drug-drug interactions, brain uptake analysis, etc. It is most often more convenient to meas... Induction of cytotoxic T-lymphocytes and antitumor activity by a liposomal lipopeptide vaccine [作者：Chen, WH; Huang, L,期刊：Molecular Pharmaceutics, 页码：464-471 , 文章类型： Article，,卷期：2008年5-3] We have previously described a simple yet effective liposome-based therapeutic vaccine, DOTAP/E7, which contains only two molecules, the cationic lipid DOTAP and a peptide antigen derived from the E7 oncoprotein of human... Water-soluble two-photon absorbing-nitrosyl complex for light-activated therapy through nitric oxide release [作者：Zheng, QD; Bonoiu, A; Ohulchanskyy, TY; He, GS; Prasad, PN,期刊：Molecular Pharmaceutics, 页码：389-398 , 文章类型： Article，,卷期：2008年5-3] A water-soluble nitrosyl complex with large two-photon absorption was synthesized by incorporating a two-photon absorbing chromophore with tetra(ethylene glycol) units, into the Roussin's red salt. The nitrosyl complex e...