个性化文献订阅>文章检索

文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共21条记录   Characterization of the in situ structural and interfacial properties of the cationic hydrophobic heteropolypeptide, KL4, in lung surfactant bilayer and monolayer models at the air-water interface: Implications for pulmonary surfactant delivery [作者：Mansour, HM; Damodaran, S; Zografi, G,期刊：Molecular Pharmaceutics, 页码：681-695 , 文章类型： Article，,卷期：2008年5-5] This study examines the various equilibrium in situ secondary structures of the pharmaceutical heteropolypeptide, KL4, in the solid state, in solution, and in the monolayer state alone and mixed with dipalmitoylphosphati... Combination chemotherapy and photodynamic therapy with Fab ' fragment targeted HPMA copolymer conjugates in human ovarian carcinoma cells [作者：Hongrapipat, J; Kopeckova, P; Liu, J; Prakongpan, S; Kopecek, J,期刊：Molecular Pharmaceutics, 页码：696-709 , 文章类型： Article，,卷期：2008年5-5] The biological activities of sequential combinations of anticancer drugs, SOS thiophene (SOS) and mesochlorin e(6) monoethylenediamine (Mce(6)), in the form of free drugs, nontargeted N-(2-hydroxypropyl)methacrylamide (H... Investigation of the redox behavior of ferroquine, a new antimalarial [作者：Chavain, N; Vezin, H; Dive, D; Touati, N; Paul, JF; Buisine, E; Biot, C,期刊：Molecular Pharmaceutics, 页码：710-716 , 文章类型： Article，,卷期：2008年5-5] Ferroquine (FQ or SR97193) is a unique ferrocene antimalarial drug candidate which just entered phase IIb clinical trials in autumn 2007. FQ is able to overcome the chloroquine (CQ) resistance problem, an important limit... Assessment of Golgi apparatus versus plasma membrane-localized multi-drug resistance-associated protein 1 [作者：Kaufmann, AM; Toro-Ramos, AJ; Krise, JP,期刊：Molecular Pharmaceutics, 页码：787-794 , 文章类型： Article，,卷期：2008年5-5] Traditionally, proteins belonging to the ATP-binding cassette superfamily have been thought to function exclusively at the plasma membrane (PM) of cells. We have previously shown multidrug resistance-associated protein 1... Surfactant-polymer nanoparticles enhance the effectiveness of anticancer photodynamic therapy [作者：Khdair, A; Gerard, B; Handa, H; Mao, GZ; Shekhar, MPV; Panyam, J,期刊：Molecular Pharmaceutics, 页码：795-807 , 文章类型： Article，,卷期：2008年5-5] Photodynamic therapy (PDT) is a promising treatment modality for cancer. PDT is based on the concept that photosensitizers, when exposed to light of specific wavelength, generate cytotoxic reactive oxygen species (ROS) c... Enhanced cancer cell growth inhibition by dipeptide prodrugs of floxuridine: Increased transporter affinity and metabolic stability [作者：Tsume, Y; Hilfinger, JM; Amidon, GL,期刊：Molecular Pharmaceutics, 页码：717-727 , 文章类型： Article，,卷期：2008年5-5] Dipeptide monoester prodrugs of floxuridine were synthesized, and their chemical stability in buffers, resistance to glycosidic bond metabolism, affinity for PEPT1, enzymatic activation and permeability in cancer cells w... In silico drug profiling of the human kinome based on a molecular marker for cross reactivity [作者：Zhang, X; Fernandez, A,期刊：Molecular Pharmaceutics, 页码：728-738 , 文章类型： Article，,卷期：2008年5-5] Protein kinases are paradigmatic targets in molecular cancer therapy. Affinity profiles of kinase drug inhibitors are of considerable interest to assess and modulate clinical drug impact. In the initial stages of discove... Stabilization of tetanus toxoid encapsulated in PLGA microspheres [作者：Jiang, WL; Schwendeman, SP,期刊：Molecular Pharmaceutics, 页码：808-817 , 文章类型： Article，,卷期：2008年5-5] Delivery of vaccine antigens from controlled-release poly(lactic/glycolic acid) (PLGA) microspheres is a novel approach to reduce the number of antigen doses required for protection against infection. A major impediment ... Cationic phospholipids forming cubic phases: Lipoplex structure and transfection efficiency [作者：Koynova, R; Wang, L; MacDonald, RC,期刊：Molecular Pharmaceutics, 页码：739-744 , 文章类型： Article，,卷期：2008年5-5] The transfection activity and the phase behavior of two novel cationic O-alkyl-phosphatidylcholines, 1,2-dioleoyl-sn-glycero-3-hexylphosphocholine (C6-DOPC) and 1,2-dierucoyl-sn-glycero-3-ethylphosphocholine (di22:1-EPC)... Combating the threat of anthrax: A quantitative structure-activity relationship approach [作者：Verma, RP; Hansch, C,期刊：Molecular Pharmaceutics, 页码：745-759 , 文章类型： Article，,卷期：2008年5-5] Bacterial agents or products more likely to be used as biological weapons of mass destruction are Bacillus anthracis, Francisella tularensis, Yersinia pestis, and the neurotoxin of Clostridium botulinum. Anthrax is an ac... Computational model for predicting chemical substituent effects on passive drug permeability across parallel artificial membranes [作者：Acharya, C; Seo, PR; Polli, JE; MacKerell, AD,期刊：Molecular Pharmaceutics, 页码：818-828 , 文章类型： Article，,卷期：2008年5-5] Drug permeability is often a limiting step in drug action, requiring chemical optimization of a drug candidate to improve this property. Such optimization is typically performed in the context of a congeneric series, whe... Intracellular processing of riboflavin in human breast cancer cells [作者：Bareford, LM; Phelps, MA; Foraker, AB; Swaan, PW,期刊：Molecular Pharmaceutics, 页码：839-848 , 文章类型： Article，,卷期：2008年5-5] A variety of polarized epithelial cells, such as human breast cancer (MCF-7), have mechanistically evolved the ability to adapt to the dynamic cellular environment and maintain homeostasis of an array of micronutrients w... Applications of physiologically based absorption models in drug discovery and development [作者：Parrott, N; Lave, T,期刊：Molecular Pharmaceutics, 页码：760-775 , 文章类型： Article，,卷期：2008年5-5] This article describes the use of physiologically based models of intestinal drug absorption to guide the research and development of new drugs. Applications range from lead optimization in the drug discovery phase throu... Novel HPMA copolymer-bound constructs for combined tumor and mitochondrial targeting [作者：Cuchelkar, V; Kopeckova, P; Kopecek, J,期刊：Molecular Pharmaceutics, 页码：776-786 , 文章类型： Article，,卷期：2008年5-5] A wide variety of therapeutic agents may benefit by specifically directing them to the mitochondria in tumor cells. The current work aimed to design delivery systems that would enable a combination of tumor and mitochond... Function-oriented synthesis: Biological evaluation of laulimalide analogues derived from a last step cross metathesis diversification strategy [作者：Mooberry, SL; Hilinski, MK; Clark, EA; Wender, PA,期刊：Molecular Pharmaceutics, 页码：829-838 , 文章类型： Article，,卷期：2008年5-5] Laulimalide is a potent microtubule stabilizing agent and a promising anticancer therapeutic lead. The identification of stable, efficacious and accessible analogues is critical to clinically exploiting this novel lead. ... 3-D tumor model for in vitro evaluation of anticancer drugs [作者：Horning, JL; Sahoo, SK; Vijayaraghavalu, S; Dimitrijevic, S; Vasir, JK; Jain, TK; Panda, AK; Labhasetwar, V,期刊：Molecular Pharmaceutics, 页码：849-862 , 文章类型： Article，,卷期：2008年5-5] The efficacy of potential anticancer drugs during preclinical development is generally tested in vitro using cancer cells grown in monolayer; however, a significant discrepancy in their efficacy is observed when these dr...