- Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain
[作者:Winter, MB; Herzik, MA; Kuriyan, J; Marletta, MA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E881-E889 , 文章类型: Article,,卷期:2011年108-43]
- Interior topological features, such as pockets and channels, have evolved in proteins to regulate biological functions by facilitating the diffusion of biomolecules. Decades of research using the globins as model heme pr...
- Locating an extracellular K(+)-dependent interaction site that modulates betaine-binding of the Na(+)-coupled betaine symporter BetP
[作者:Ge, L; Perez, C; Waclawska, I; Ziegler, C; Muller, DJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E890-E898 , 文章类型: Article,,卷期:2011年108-43]
- BetP, a trimeric Na(+)-coupled betaine symporter, senses hyperosmotic stress via its cytoplasmic C-terminal domain and regulates transport activity in dependence of the cytoplasmic K(+)-concentration. This transport regu...
- Cardiac myocyte follistatin-like 1 functions to attenuate hypertrophy following pressure overload
[作者:Shimano, M; Ouchi, N; Nakamura, K; van Wijk, B; Ohashi, K; Asaumi, Y; Higuchi, A; Pimentel, DR; Sam, F; Murohara, T; van den Hoff, MJB; Walsh, K,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E899-E906 , 文章类型: Article,,卷期:2011年108-43]
- Factors secreted by the heart, referred to as "cardiokines," have diverse actions in the maintenance of cardiac homeostasis and remodeling. Follistatin-like 1 (Fstl1) is a secreted glycoprotein expressed in the adult hea...
- Identifying critical regions in small-world marine metapopulations
[作者:Watson, JR; Siegel, DA; Kendall, BE; Mitarai, S; Rassweiller, A; Gaines, SD,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E907-E913 , 文章类型: Article,,卷期:2011年108-43]
- The precarious state of many nearshore marine ecosystems has prompted the use of marine protected areas as a tool for management and conservation. However, there remains substantial debate over their design and, in parti...
- Independent modulation of the kinase and polo-box activities of Cdc5 protein unravels unique roles in the maintenance of genome stability
[作者:Ratsima, H; Ladouceur, AM; Pascariu, M; Sauve, V; Salloum, Z; Maddox, PS; D'Amours, D,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E914-E923 , 文章类型: Article,,卷期:2011年108-43]
- Polo-like kinases (PLKs) are evolutionarily conserved kinases essential for cell cycle regulation. These kinases are characterized by the presence of a C-terminal phosphopeptide-interaction domain, the polo-box domain (P...
- Hypoxia-induced transcriptional repression of the melanoma-associated oncogene MITF
[作者:Feige, E; Yokoyama, S; Levy, C; Khaled, M; Igras, V; Lin, RJ; Lee, S; Widlund, HR; Granter, SR; Kung, AL; Fisher, DE,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E924-E933 , 文章类型: Article,,卷期:2011年108-43]
- Microphthalmia- associated transcription factor (MITF) regulates normal melanocyte development and is also a lineage-selective oncogene implicated in melanoma and clear-cell sarcoma (i.e., melanoma of soft parts). We hav...
- Requirement for complement in antibody responses is not explained by the classic pathway activator IgM
[作者:Rutemark, C; Alicot, E; Bergman, A; Ma, MH; Getahun, A; Ellmerich, S; Carroll, MC; Heyman, B,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E934-E942 , 文章类型: Article,,卷期:2011年108-43]
- Animals lacking complement factors C1q, C2, C3, or C4 have severely impaired Ab responses, suggesting a major role for the classic pathway. The classic pathway is primarily initiated by antigen-Ab complexes. Therefore, i...
- A whole-genome RNAi screen identifies an 8q22 gene cluster that inhibits death receptor-mediated apoptosis
[作者:Dompe, N; Rivers, CS; Li, L; Cordes, S; Schwickart, M; Punnoose, EA; Amler, L; Seshagiri, S; Tang, J; Modrusan, Z; Davis, DP,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E943-E951 , 文章类型: Article,,卷期:2011年108-43]
- Deregulation of apoptosis is a common occurrence in cancer, for which emerging oncology therapeutic agents designed to engage this pathway are undergoing clinical trials. With the aim of uncovering strategies to activate...
- Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling
[作者:Beirowski, B; Gustin, J; Armour, SM; Yamamoto, H; Viader, A; North, BJ; Michan, S; Baloh, RH; Golden, JP; Schmidt, RE; Sinclair, DA; Auwerx, J; Milbrandt, J,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E952-E961 , 文章类型: Article,,卷期:2011年108-43]
- The formation of myelin by Schwann cells (SCs) occurs via a series of orchestrated molecular events. We previously used global expression profiling to examine peripheral nerve myelination and identified the NAD(+)-depend...
- Dysbindin-1 mutant mice implicate reduced fast-phasic inhibition as a final common disease mechanism in schizophrenia
[作者:Carlson, GC; Talbot, K; Halene, TB; Gandal, MJ; Kazi, HA; Schlosser, L; Phung, QH; Gur, RE; Arnold, SE; Siegel, SJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E962-E970 , 文章类型: Article,,卷期:2011年108-43]
- DTNBP1 (dystrobrevin binding protein 1) is a leading candidate susceptibility gene in schizophrenia and is associated with working memory capacity in normal subjects. In schizophrenia, the encoded protein dystrobrevin-bi...
- Compact and flexible raster scanning multiphoton endoscope capable of imaging unstained tissue
[作者:Rivera, DR; Brown, CM; Ouzounov, DG; Pavlova, I; Kobat, D; Webb, WW; Xu, C,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17598-17603 , 文章类型: Article,,卷期:2011年108-43]
- We present a compact and flexible endoscope (3-mm outer diameter, 4-cm rigid length) that utilizes a miniaturized resonant/nonresonant fiber raster scanner and a multielement gradient-index lens assembly for two-photon e...
- Structure determination of an intercalating ruthenium dipyridophenazine complex which kinks DNA by semiintercalation of a tetraazaphenanthrene ligand
[作者:Hall, JP; O'Sullivan, K; Naseer, A; Smith, JA; Kelly, JM; Cardin, CJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17610-17614 , 文章类型: Article,,卷期:2011年108-43]
- We describe a crystal structure, at atomic resolution (1.1 angstrom, 100 K), of a ruthenium polypyridyl complex bound to duplex DNA, in which one ligand acts as a wedge in the minor groove, resulting in the 51 degrees ki...
|