- Regulation of DNA replication during development
[作者:Nordman, J; Orr-Weaver, TL,期刊:Development, 页码:455-464 , 文章类型: Article,,卷期:2012年139-3]
- As development unfolds, DNA replication is not only coordinated with cell proliferation, but is regulated uniquely in specific cell types and organs. This differential regulation of DNA synthesis requires crosstalk betwe...
- Cdx2 determines the fate of postnatal intestinal endoderm
[作者:Stringer, EJ; Duluc, I; Saandi, T; Davidson, I; Bialecka, M; Sato, T; Barker, N; Clevers, H; Pritchard, CA; Winton, DJ; Wright, NA; Freund, JN; Deschamps, J; Beck, F,期刊:Development, 页码:465-474 , 文章类型: Article,,卷期:2012年139-3]
- Knock out of intestinal Cdx2 produces different effects depending upon the developmental stage at which this occurs. Early in development it produces histologically ordered stomach mucosa in the midgut. Conditional inact...
- p57(KIP2) regulates radial glia and intermediate precursor cell cycle dynamics and lower layer neurogenesis in developing cerebral cortex
[作者:Mairet-Coello, G; Tury, A; Van Buskirk, E; Robinson, K; Genestine, M; DiCicco-Bloom, E,期刊:Development, 页码:475-487 , 文章类型: Article,,卷期:2012年139-3]
- During cerebral cortex development, precise control of precursor cell cycle length and cell cycle exit is required for balanced precursor pool expansion and layer-specific neurogenesis. Here, we defined the roles of cycl...
- Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells
[作者:VanDussen, KL; Carulli, AJ; Keeley, TM; Patel, SR; Puthoff, BJ; Magness, ST; Tran, IT; Maillard, I; Siebel, C; Kolterud, A; Grosse, AS; Gumucio, DL; Ernst, SA; Tsai, YH; Dempsey, PJ; Samuelson, LC,期刊:Development, 页码:488-497 , 文章类型: Article,,卷期:2012年139-3]
- Notch signaling is known to regulate the proliferation and differentiation of intestinal stem and progenitor cells; however, direct cellular targets and specific functions of Notch signals had not been identified. We sho...
- LACHESIS-dependent egg-cell signaling regulates the development of female gametophytic cells
[作者:Volz, R; von Lyncker, L; Baumann, N; Dresselhaus, T; Sprunck, S; Gross-Hardt, R,期刊:Development, 页码:498-502 , 文章类型: Article,,卷期:2012年139-3]
- In contrast to animals, plant germ cells are formed along with accessory cells in specialized haploid generations, termed gametophytes. The female gametophyte of flowering plants consists of four different cell types, wh...
- Midbrain-hindbrain boundary patterning and morphogenesis are regulated by diverse grainy head-like 2-dependent pathways
[作者:Dworkin, S; Darido, C; Georgy, SR; Wilanowski, T; Srivastava, S; Ellett, F; Pase, L; Han, YC; Meng, AM; Heath, JK; Lieschke, GJ; Jane, SM,期刊:Development, 页码:525-536 , 文章类型: Article,,卷期:2012年139-3]
- The isthmic organiser located at the midbrain-hindbrain boundary (MHB) is the crucial developmental signalling centre responsible for patterning mesencephalic and metencephalic regions of the vertebrate brain. Formation ...
- CycA is involved in the control of endoreplication dynamics in the Drosophila bristle lineage
[作者:Salle, J; Campbell, SD; Gho, M; Audibert, A,期刊:Development, 页码:547-557 , 文章类型: Article,,卷期:2012年139-3]
- Endocycles, which are characterised by repeated rounds of DNA replication without intervening mitosis, are involved in developmental processes associated with an increase in metabolic cell activity and are part of termin...
- Deficient Notch signaling associated with neurogenic pecanex is compensated for by the unfolded protein response in Drosophila
[作者:Yamakawa, T; Yamada, K; Sasamura, T; Nakazawa, N; Kanai, M; Suzuki, E; Fortini, ME; Matsuno, K,期刊:Development, 页码:558-567 , 文章类型: Article,,卷期:2012年139-3]
- The Notch (N) signaling machinery is evolutionarily conserved and regulates a broad spectrum of cell-specification events, through local cell-cell communication. pecanex (pcx) encodes a multi-pass transmembrane protein o...
- Chondrocytic Atf4 regulates osteoblast differentiation and function via Ihh
[作者:Wang, WG; Lian, N; Ma, Y; Li, LZ; Gallant, RC; Elefteriou, F; Yang, XL,期刊:Development, 页码:601-611 , 文章类型: Article,,卷期:2012年139-3]
- Atf4 is a leucine zipper-containing transcription factor that activates osteocalcin (Ocn) in osteoblasts and indian hedgehog (Ihh) in chondrocytes. The relative contribution of Atf4 in chondrocytes and osteoblasts to the...
- The extracellular loops of Smoothened play a regulatory role in control of Hedgehog pathway activation
[作者:Carroll, CE; Marada, S; Stewart, DP; Ouyang, JXX; Ogden, SK,期刊:Development, 页码:612-621 , 文章类型: Article,,卷期:2012年139-3]
- The Hedgehog (Hh) signaling pathway plays an instructional role during development, and is frequently activated in cancer. Ligand-induced pathway activation requires signaling by the transmembrane protein Smoothened (Smo...
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