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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共17条记录   Molecular biology, genetics and biochemistry of the repulsive guidance molecule family [作者：Severyn, CJ; Shinde, U; Rotwein, P,期刊：Biochemical Journal, 页码：393-403 , 文章类型： Review，,卷期：2009年422-Part 3] RGMs (repulsive guidance molecules) comprise a recently discovered family of GPI (glycosylphospliatidylinositol)-linked cell-membrane-associated proteins found in most vertebrate species. The three proteins, RGMa, RGMb a... Metabolic control exerted by the 2-oxoglutarate dehydrogenase reaction: a cross-kingdom comparison of the crossroad between energy production and nitrogen assimilation [作者：Bunik, VI; Fernie, AR,期刊：Biochemical Journal, 页码：405-421 , 文章类型： Review，,卷期：2009年422-Part 3] Mechanism-based inhibitors and both forward and reverse genetics have proved to be essential tools in revealing roles for specific enzymatic processes in cellular function. Here, we review experimental studies aimed at a... Sodium nitrite therapy attenuates the hypertensive effects of HBOC-201 via nitrite reduction [作者：Rodriguez, C; Vitturi, DA; He, J; Vandromme, M; Brandon, A; Hutchings, A; Rue, LW; Kerby, JD; Patel, RP,期刊：Biochemical Journal, 页码：423-432 , 文章类型： Article，,卷期：2009年422-Part 3] Hypertension secondary to scavenging of NO remains a limitation in the use of HBOCs (haemoglobin-based oxygen carriers). Recent studies suggest that nitrite reduction to NO by deoxyhaemoglobin supports NO signalling. In ... Ephrin-independent regulation of cell substrate adhesion by the EphB4 receptor [作者：Noren, NK; Yang, NY; Silldorff, M; Mutyala, R; Pasquale, EB,期刊：Biochemical Journal, 页码：433-442 , 文章类型： Article，,卷期：2009年422-Part 3] Receptor tyrosine kinases of the Eph family become tyrosine phosphorylated and initiate signalling events upon binding of their ligands, the ephrins. Eph receptors such as EphA2 and EphB4 are highly expressed but poorly ... Human Ccr4-Not complexes contain variable deadenylase subunits [作者：Lau, NC; Kolkman, A; van Schaik, FMA; Mulder, KW; Pijnappel, WWMP; Heck, AJR; Timmers, HTM,期刊：Biochemical Journal, 页码：443-453 , 文章类型： Article，,卷期：2009年422-Part 3] The Ccr4-Not complex is evolutionarily conserved and important for regulation of mRNA synthesis and decay. The composition of the yeast complex has been well described. Orthologues of the yeast Ccr4-Not components have b... Inhibitory effects of kynurenic acid, a tryptophan metabolite, and its derivatives on cytosolic sulfotransferases [作者：Senggunprai, L; Yoshinari, K; Yamazoe, Y,期刊：Biochemical Journal, 页码：455-462 , 文章类型： Article，,卷期：2009年422-Part 3] KYNA (kynurenic acid) is an endogenous metabolite of tryptophan in the kynurenine pathway and has been characterized as an antagonist of ionotropic glutamate receptors. In addition, we have reported this endogenous compo... Molecular recognition of physiological substrate noradrenaline by the adrenaline-synthesizing enzyme PNMT and factors influencing its methyltransferase activity [作者：Drinkwater, N; Gee, CL; Puri, M; Criscione, KR; McLeish, MJ; Grunewald, GL; Martin, JL,期刊：Biochemical Journal, 页码：463-471 , 文章类型： Article，,卷期：2009年422-Part 3] Substrate specificity is critically important for enzyme catalysis. In the adrenaline-synthesizing enzyme PNMT (phenylethanolamine N-methyltransferase), minor changes in substituents can convert substrates into inhibitor... Two novel phosphatidylinositol-4-phosphate 5-kinase type I gamma splice variants expressed in human cells display distinctive cellular targeting [作者：Schill, NJ; Anderson, RA,期刊：Biochemical Journal, 页码：473-482 , 文章类型： Article，,卷期：2009年422-Part 3] The generation of various phosphoinositide messenger molecules at distinct locations within the cell is mediated via the specific targeting of different isoforms and splice variants of phosphoinositide kinases. The lipid... Functional conservation of tRNase Z(L) among Saccharomyces cerevisiae, Schizosaccharomyces pombe and humans [作者：Zhao, Z; Su, WC; Yuan, S; Huang, Y,期刊：Biochemical Journal, 页码：483-492 , 文章类型： Article，,卷期：2009年422-Part 3] Although tRNase Z from various organisms was shown to process nuclear tRNA 3' ends in vitro, only a very limited number of studies have reported its in vivo biological functions. tRNase Z is present in a short form, tRNa... The transcriptional activity of Pygopus is enhanced by its interaction with cAMP-response-element-binding protein (CREB)-binding protein [作者：Andrews, PGP; He, ZJ; Popadiuk, C; Kao, KR,期刊：Biochemical Journal, 页码：493-501 , 文章类型： Article，,卷期：2009年422-Part 3] Pygopus is a core component of the beta-catenin/TCF (T-cell factor) transcriptional activation complex required for the expression of canonical Wnt target genes. Recent evidence suggests that Pygopus could interpret hist... Recruitment of NAADP-sensitive acidic Ca2+ stores by glutamate [作者：Pandey, V; Chuang, CC; Lewis, AM; Aley, PK; Brailoiu, E; Dun, NJ; Churchill, GC; Patel, S,期刊：Biochemical Journal, 页码：503-512 , 文章类型： Article，,卷期：2009年422-Part 3] NAADP (nicotinic acid-adenine dinucleotide phosphate) is an unusual second messenger thought to mobilize acidic Ca2+ stores, such as lysosomes or lysosome-like organelles, that are functionally coupled to the ER (endopla... Origin of pyrimidine deoxyribonucleotide pools in perfused rat heart: implications for 3 '-azido-3 '-deoxythymidine-dependent cardiotoxicity [作者：Morris, GW; Iams, TA; Slepchenko, KG; McKee, EE,期刊：Biochemical Journal, 页码：513-520 , 文章类型： Article，,卷期：2009年422-Part 3] In adult non-replicating tissues such as heart, demand for dNTPs (deoxynucleoside triphosphates) is low but essential for mitochrondrial DNA replication and nuclear DNA repair. dNTP`s may be synthesized from salvage of d... Interaction of mitochondrial thioredoxin with glucocorticoid receptor and NF-kappa B modulates glucocorticoid receptor and NF-kappa B signalling in HEK-293 cells [作者：Psarra, AMG; Hermann, S; Panayotou, G; Spyrou, G,期刊：Biochemical Journal, 页码：521-531 , 文章类型： Article，,卷期：2009年422-Part 3] Trx2 (mitochondrial thioredoxin) is an antioxidant and antiapoptotic factor essential for cell viability. Trx1 (cytoplasmic thioredoxin) is a co-factor and regulator of redox-sensitive transcription factors such as the G... Chemokine degradation by the Group A streptococcal serine proteinase ScpC can be reconstituted in vitro and requires two separate domains [作者：Fritzer, A; Noiges, B; Schweiger, D; Rek, A; Kungl, AJ; von Gabain, A; Nagy, E; Meinke, AL,期刊：Biochemical Journal, 页码：533-542 , 文章类型： Article，,卷期：2009年422-Part 3] Streptococcus pyogenes is one of the most common human pathogens and possesses diverse mechanisms to evade the human immune defence. One example of its immune evasion is the degradation of the chemokine IL (interieukin)-... DNA damage signalling recruits RREB-1 to the p53 tumour suppressor promoter [作者：Liu, HS; Hew, HC; Lu, ZG; Yamaguchi, T; Miki, Y; Yoshida, K,期刊：Biochemical Journal, 页码：543-551 , 文章类型： Article，,卷期：2009年422-Part 3] Transcriptional regulation of the p53 tumour suppressor gene plays an important role in the control of the expression of various target genes involved in the DNA damage response. However, the molecular basis of this regu... Generation and functional characterization of a BCL10-inhibitory peptide that represses NF-kappa B activation [作者：Marasco, D; Stilo, R; Sandomenico, A; Monti, SM; Tizzano, B; De Capua, A; Varricchio, E; Liguoro, D; Zotti, T; Formisano, S; Ruvo, M; Vito, P,期刊：Biochemical Journal, 页码：553-561 , 文章类型： Article，,卷期：2009年422-Part 3] The molecular complex containing BCL10 and CARMA [CARD (caspase recruitment domain)-containing MAGUK (membrane-associated guanylate kinase)] proteins has recently been identified as a key component in the signal transduc...