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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共14条记录   The hepatitis C virus and its hepatic environment: a toxic but finely tuned partnership [作者：Perrault, M; Pecheur, EI,期刊：Biochemical Journal, 页码：303-314 , 文章类型： Review，,卷期：2009年423-Part 3] Twenty years after its discovery, HCV (hepatitis C virus) still infects 170 million people worldwide and cannot be properly treated due to the lack of efficient medication. Its life cycle must be better understood to dev... Nutrient isothiocyanates covalently modify and inhibit the inflammatory cytokine macrophage migration inhibitory factor (MIF) [作者：Cross, JV; Rady, JM; Foss, FW; Lyons, CE; MacDonald, TL; Templeton, DJ,期刊：Biochemical Journal, 页码：315-321 , 文章类型： Article，,卷期：2009年423-Part 3] Dietary ITCs (isothiocyanates) prevent cancer and show other bioactivities in vivo. As electrophiles, ITCs may covalently modify cellular proteins. Using a novel proteomics screen, we identified MIF (macrophage migration... Evolution of vertebrate glucokinase regulatory protein from a bacterial N-acetylmuramate 6-phosphate etherase [作者：Veiga-da-Cunha, M; Sokolova, T; Opperdoes, F; Van Schaftingen, E,期刊：Biochemical Journal, 页码：323-332 , 文章类型： Article，,卷期：2009年423-Part 3] Mammalian GKRP [GK (glucokinase) regulatory protein], a fructose 6-phosphate and fructose I-phosphate sensitive inhibitor of GK, appears to have resulted from the duplication of a gene similar to bacterial N-acetylmurama... Eukaryatic GCP1 is a conserved mitochondrial protein required for progression of embryo development beyond the globular stage in Arabidopsis thaliana [作者：Haussuehl, K; Huesgen, PF; Meier, M; Dessi, P; Glaser, E; Adamski, J; Adamska, I,期刊：Biochemical Journal, 页码：333-341 , 文章类型： Article，,卷期：2009年423-Part 3] GCPs (glycoproteases) are members of the HSP70 (beat-shock protein 70)/actin ATPase superfamily that are highly conserved in taxonomically diverse species from bacteria to man, suggesting an essential physiological role.... Urokinase-receptor-mediated phenotypic changes in vascular smooth muscle cells require the involvement of membrane rafts [作者：Kiyan, J; Smith, G; Haller, H; Dumler, I,期刊：Biochemical Journal, 页码：343-351 , 文章类型： Article，,卷期：2009年423-Part 3] The cholesterol-enriched membrane microdomains lipid rafts play a key role in cell activation by recruiting and excluding specific signalling components of cell-surface receptors upon receptor engagement. Our previous st... Fluorine substitutions in an antigenic peptide selectively modulate T-cell receptor binding in a minimally perturbing manner [作者：Piepenbrink, KH; Borbulevych, OY; Sommese, RF; Clemens, J; Armstrong, KM; Desmond, C; Do, P; Baker, BM,期刊：Biochemical Journal, 页码：353-361 , 文章类型： Article，,卷期：2009年423-Part 3] TCR (T-cell receptor) recognition of antigenic peptides bound and presented by MHC (major histocompatibility complex) molecules forms the basis of the cellular immune response to pathogens and cancer. TCRs bind peptide-M... The NADPH oxidase Nox4 restricts the replicative lifespan of human endothelial cells [作者：Lener, B; Koziel, R; Pircher, H; Hutter, E; Greussing, R; Herndler-Brandstetter, D; Hermann, M; Unterluggauer, H; Jansen-Durr, P,期刊：Biochemical Journal, 页码：363-374 , 文章类型： Article，,卷期：2009年423-Part 3] The free radical theory of aging proposes that ROS (reactive oxygen species) are major driving forces of aging, and are also critically involved in cellular senescence. Besides the mitochondrial respiratory chain, altern... Angiopoietin-1-induced ubiquitylation of Tie2 by c-Cbl is required for internalization and degradation [作者：Wehrle, C; Van Slyke, P; Dumont, DJ,期刊：Biochemical Journal, 页码：375-380 , 文章类型： Article，,卷期：2009年423-Part 3] Tie2 [where 'Tie' is an acronym from lyrosine kinase with Ig and EGF (epidermal growth factor) homology domains] is a receptor tyrosine kinase expressed predominantly on the surface of endothelial cells. Activated by its... MAC inhibitors suppress mitochondrial apoptosis [作者：Peixoto, PM; Ryu, SY; Bombrun, A; Antonsson, B; Kinnally, KW,期刊：Biochemical Journal, 页码：381-387 , 文章类型： Article，,卷期：2009年423-Part 3] MAC (mitochondrial apoptosis-induced channel) forms in the mitochondrial outer membrane and unleashes cytochrorne c to orchestrate the execution of the cell. MAC opening is the commitment step of intrinsic apoptosis. Hen... Functional characterization of the interactions between endosomal adaptor protein APPL1 and the NuRD co-repressor complex [作者：Banach-Orlowska, M; Pilecka, I; Torun, A; Pyrzynska, B; Miaczynska, M,期刊：Biochemical Journal, 页码：389-400 , 文章类型： Article，,卷期：2009年423-Part 3] Multifunctional adaptor protein APPL1 [adaptor protein containing PH (pleckstrin homology) domain, PTB (phosphotyrosine binding) domain and leucine zipper motif] belongs to a growing group of endocytic proteins which act... Binding of cyclic nucleotides to phosphodiesterase 10A and 11A GAF domains does not stimulate catalytic activity [作者：Matthiesen, K; Nielsen, J,期刊：Biochemical Journal, 页码：401-409 , 文章类型： Article，,卷期：2009年423-Part 3] To date eleven human PDE (3',5'-cyclic nucleotide phosphodiesterase) families have been identified. Of these, five families contain non-catalytic tandem GAF (c (G) under bar MP-specific and stimulated phosphodiesterases,... C-terminal sequences of hsp70 and hsp90 as non-specific anchors for tetratricopeptide repeat (TPR) proteins [作者：Ramsey, AJ; Russell, LC; Chinkers, M,期刊：Biochemical Journal, 页码：411-419 , 文章类型： Article，,卷期：2009年423-Part 3] Steroid-hormone-receptor maturation is a multi-step process that involves several TPR (tetratricopeptide repeat) proteins that bind to the maturation complex via the C-termini of hsp70 (heat-shock protein 70) and hsp90 (... Effect of pyruvate, lactate and insulin on ATP supply and demand in unpaced perfused rat heart [作者：Korzeniewski, B; Deschodt-Arsac, V; Calmettes, G; Gouspillou, G; Franconi, JM; Diolez, P,期刊：Biochemical Journal, 页码：421-428 , 文章类型： Article，,卷期：2009年423-Part 3] Mitochondrial respiration/oxidative phosphorylation is the main source of energy, in the form of ATP, in the heart under physiological conditions. Different respiratory substrates were used in various experiments during ... The crystal structure of caspase-6, a selective effector of axonal degeneration [作者：Baumgartner, R; Meder, G; Briand, C; Decock, A; D'Arcy, A; Hassiepen, U; Morse, R; Renatus, M,期刊：Biochemical Journal, 页码：429-439 , 文章类型： Article，,卷期：2009年423-Part 3] Neurodegenerative diseases pose one of the most pressing unmet medical needs today. It has long been recognized that caspase-6 may play a role in several neurodegenerative diseases for which there are currently no diseas...