- Expression of the iron-regulatory protein haemojuvelin in retina and its regulation during cytomegalovirus infection
[作者:Gnana-Prakasam, JP; Zhang, M; Martin, PM; Atherton, SS; Smith, SB; Ganapathy, V,期刊:Biochemical Journal, 页码:533-543 , 文章类型: Article,,卷期:2009年419-Part 3]
- Haemochromatosis is a genetic disorder of iron overload resulting from loss-of-function mutations in genes coding for the iron-regulatory proteins HFE [HLA-like protein involved in iron (Fe) homoeostasis], transferrin re...
- Structural and functional characterization of SplA, an exclusively specific protease of Staphylococcus aureus
[作者:Stec-Niemczyk, J; Pustelny, K; Kisielewska, M; Bista, M; Boulware, KT; Stiennicke, HR; Thogersen, IB; Daugherty, PS; Enghild, JJ; Baczynski, K; Popowicz, GM; Dubin, A; Potempa, J; Dubin, G,期刊:Biochemical Journal, 页码:555-564 , 文章类型: Article,,卷期:2009年419-Part 3]
- Staphylococcus aureus is a dangerous human pathogen whose antibiotic resistance is steadily increasing and no efficient vaccine is as yet available. This serious threat drives extensive studies on staphylococcal physiolo...
- Lipid rafts enriched in phosphatidylglucoside direct astroglial differentiation by regulating tyrosine kinase activity of epidermal growth factor receptors
[作者:Kinoshita, MO; Furuya, S; Ito, S; Shinoda, Y; Yamazaki, Y; Greimel, P; Ito, Y; Hashikawa, T; Machida, T; Nagatsuka, Y; Hirabayashi, Y,期刊:Biochemical Journal, 页码:565-575 , 文章类型: Article,,卷期:2009年419-Part 3]
- Membrane lipid rafts provide a specialized microenvironment enriched with sphingolipids and phospholipids containing saturated fatty acids and serve as a platform for various intracellular signalling pathways. PtdGlc (ph...
- Antibody-mediated disruption of the interaction between PCSK9 and the low-density lipoprotein receptor
[作者:Duff, CJ; Scottt, MJ; Kirby, IT; Hutchinson, SE; Martin, SL; Hooper, NM,期刊:Biochemical Journal, 页码:577-584 , 文章类型: Article,,卷期:2009年419-Part 3]
- PCSK9 (proprotein convertase subtilisin/kexin type 9) promotes degradation of the LDLR [LDL (low-density lipoprotein) receptor] through an as-yet-undefined mechanism, leading to a reduction in cellular LDLc (LDL-choleste...
- Molecular analysis of heparan sulfate biosynthetic enzyme machinery and characterization of heparan sulfate structure in Nematostella vectensis
[作者:Feta, A; Do, AT; Rentzsch, F; Technau, U; Kusche-Gullberg, M,期刊:Biochemical Journal, 页码:585-593 , 文章类型: Article,,卷期:2009年419-Part 3]
- HS (heparan sulfate) proteoglycans are key regulators of vital processes in the body. HS chains with distinct sequences bind to various protein ligands, such as growth factors and morphogens, and thereby function as impo...
- The C-terminus of the P22 tailspike protein acts as an independent oligomerization domain for monomeric proteins
[作者:Webber, T; Gurung, S; Saul, J; Baker, T; Spatara, M; Freyer, M; Robinson, AS; Gage, MJ,期刊:Biochemical Journal, 页码:595-602 , 文章类型: Article,,卷期:2009年419-Part 3]
- TSP (P22 tailspike protein) is a well-established model system for studying the folding and assembly of oligomeric proteins, and previous studies have documented both in vivo and in vitro folding intermediates using this...
- PI3K gamma controls oxidative bursts in neutrophils via interactions with PKC alpha and p47phox
[作者:Lehmann, K; Muller, JR; Schlott, B; Skroblin, P; Barz, D; Norgauer, J; Wetzker, R,期刊:Biochemical Journal, 页码:603-610 , 文章类型: Article,,卷期:2009年419-Part 3]
- Neutrophils release reactive oxygen species (ROS) as part of the innate inflammatory immune response. Phosphoinositide 3-kinase gamma (PI3K gamma), which is indUced by the bacterial peptide N-formylmethionyl-leucyl-pheny...
- Lipid phosphate phosphohydrolase type 1 (LPP1) degrades extracellular lysophosphatidic acid in vivo
[作者:Tomsig, JL; Snyder, AH; Berdyshev, EV; Skobeleva, A; Mataya, C; Natarajan, V; Brindley, DN; Lynch, KR,期刊:Biochemical Journal, 页码:611-618 , 文章类型: Article,,卷期:2009年419-Part 3]
- LPA (lysophosphatidic acid) is a lipid mediator that stimulates cell proliferation and growth, and is involved in physiological and pathological processes Such as wound healing, platelet activation, angiogenesis and the ...
- Structure of human insulin-like peptide 5 and characterization of conserved hydrogen bonds and electrostatic interactions within the relaxin framework
[作者:Haugaard-Jonsson, LM; Hossain, MA; Daly, NL; Craik, DJ; Wade, JD; Rosengre, KJ,期刊:Biochemical Journal, 页码:619-627 , 文章类型: Article,,卷期:2009年419-Part 3]
- INSL5 (insulin-like peptide 5) is a two-chain peptide hormone related to insulin and relaxin. It was recently discovered through searches of expressed sequence tag databases and, although the fulfil biological significan...
- Proper expression of helix-loop-helix protein Id2 is important to chondrogenic differentiation of ATDC5 cells
[作者:Yang, L; Ma, XY; Lyone, A; Zou, JH; Blackburn, ML; Pan, J; Yang, DQ; Matsushita, H; Mei, B; Zielinska-Kwiatkowska, A; Chansky, HA,期刊:Biochemical Journal, 页码:635-643 , 文章类型: Article,,卷期:2009年419-Part 3]
- The process of chondrogenesis can be mimicked in vitro by insulin treatment of mouse ATDC5 chondroprogenitor cells. To identify novel factors that are involved in the control of chondrogenesis, we carried out a large-sca...
- Characterization of two distinct binding modes between syntaxin 4 and Munc18c
[作者:Aran, V; Brandie, FM; Boyd, AR; Kantidakis, T; Rideout, EJ; Kelly, SM; Gould, GW; Bryant, NJ,期刊:Biochemical Journal, 页码:655-660 , 文章类型: Article,,卷期:2009年419-Part 3]
- Interaction of SM (Sec1/Munc18) proteins with their cognate syntaxins represents an important regulatory mechanism of SNARE (soluble N-ethylmaleimide-sensitive fusion protein-attachment protein receptor)-mediated membran...
- The assembly of CD1e is controlled by an N-terminal propeptide which is processed in endosomal compartments
[作者:Maitre, B; Angenieux, C; Wurtz, V; Layre, E; Gilleron, M; Collmann, A; Mariotti, S; Mori, L; Fricker, D; Cazenave, JP; Van Dorsselaer, A; Gachet, C; De Libero, G; Puzo, G; Hanau, D; de la Salle, H,期刊:Biochemical Journal, 页码:661-668 , 文章类型: Article,,卷期:2009年419-Part 3]
- CD1e displays unique features in comparison with other CD1 proteins. CD1e accumulates in Golgi compartments of immature dendritic cells and is transported directly to lysosomes, where it is cleaved into it soluble form. ...
- Mitogen-activated protein kinase-mediated phosphorylation of peroxiredoxin 6 regulates its phospholipase A(2) activity
[作者:Wu, Y; Feinstein, SI; Manevich, Y; Chowdhury, I; Pak, JH; Kazi, A; Dodia, C; Speicher, DW; Fisher, AB,期刊:Biochemical Journal, 页码:669-679 , 文章类型: Article,,卷期:2009年419-Part 3]
- Prdx6 (peroxiredoxin 6), a bifunctional protein with both GSH peroxidase and PLA(2) (phospholipase A(2)) [aiPLA(2) (acidic calcium-independent PLA(2))] activities, is responsible for the metabolism of lung surfactant pho...
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