- Structural Basis for Proficient Incorporation of dTTP Opposite O-6-Methylguanine by Human DNA Polymerase i
[作者:Pence, MG; Choi, JY; Egli, M; Guengerich, FP,期刊:Journal of Biological Chemistry, 页码:889-898 , 文章类型: Article,,卷期:2010年285-52]
- O-6-Methylguanine (O-6-methylG) is highly mutagenic and is commonly found in DNA exposed to methylating agents, even physiological ones (e.g. S-adenosylmethionine). The efficiency of a truncated, catalytic DNA polymerase...
- Crystal Structure of Hexokinase KlHxk1 of Kluyveromyces lactis A MOLECULAR BASIS FOR UNDERSTANDING THE CONTROL OF YEAST HEXOKINASE FUNCTIONS VIA COVALENT MODIFICATION AND OLIGOMERIZATION
[作者:Kuettner, EB; Kettner, K; Keim, A; Svergun, DI; Volke, D; Singer, D; Hoffmann, R; Muller, EC; Otto, A; Kriegel, TM; Strater, N,期刊:Journal of Biological Chemistry, 页码:U161-U168 , 文章类型: Article,,卷期:2010年285-52]
- Crystal structures of the unique hexokinase KlHxk1 of the yeast Kluyveromyces lactis were determined using eight independent crystal forms. In five crystal forms, a symmetrical ring-shaped homodimer was observed, corresp...
- Structural Bases of PAS Domain-regulated Kinase (PASK) Activation in the Absence of Activation Loop Phosphorylation
[作者:Kikani, CK; Antonysamy, SA; Bonanno, JB; Romero, R; Zhang, FF; Russell, M; Gheyi, T; Iizuka, M; Emtage, S; Sauder, JM; Turk, BE; Burley, SK; Rutter, J,期刊:Journal of Biological Chemistry, 页码:U161-U168 , 文章类型: Article,,卷期:2010年285-52]
- Per-Arnt-Sim (PAS) domain-containing protein kinase (PASK) is an evolutionary conserved protein kinase that coordinates cellular metabolism with metabolic demand in yeast and mammals. The molecular mechanisms underlying ...
- Functional Hypervariability and Gene Diversity of Cardioactive Neuropeptides
[作者:Moller, C; Melaun, C; Castillo, C; Diaz, ME; Renzelman, CM; Estrada, O; Kuch, U; Lokey, S; Mari, F,期刊:Journal of Biological Chemistry, 页码:889-898 , 文章类型: Article,,卷期:2010年285-52]
- Crustacean cardioactive peptide (CCAP) and related peptides are multifunctional regulatory neurohormones found in invertebrates. We isolated a CCAP-related peptide (conoCAP-a, for cone snail CardioActive Peptide) and clo...
- Feed-forward Signaling by Membrane-bound Ligand Receptor Circuit THE CASE OF NOTCH DELTA-LIKE 4 LIGAND IN ENDOTHELIAL CELLS
[作者:Caolo, V; van den Akker, NMS; Verbruggen, S; Donners, MMPC; Swennen, G; Schulten, H; Waltenberger, J; Post, MJ; Molin, DGM,期刊:Journal of Biological Chemistry, 页码:889-898 , 文章类型: Article,,卷期:2010年285-52]
- The DELTA like-4 ligand (DLL4) belongs to the highly conserved NOTCH family and is specifically expressed in the endothelium. DLL4 regulates crucial processes in vascular growth, including endothelial cell (EC) sprouting...
- Genetic Analysis of Type-1 Insulin-like Growth Factor Receptor Signaling through Insulin Receptor Substrate-1 and -2 in Pancreatic beta Cells
[作者:Xuan, SH; Szabolcs, M; Cinti, F; Perincheri, S; Accili, D; Efstratiadis, A,期刊:Journal of Biological Chemistry, 页码:U161-U168 , 文章类型: Article,,卷期:2010年285-52]
- Signaling by receptor tyrosine kinases regulates pancreatic beta cell function. Inactivation of insulin receptor (InsR), IGF1 receptor (Igf1r), or Irs1 in beta cells impairs insulin secretion. Conversely, Irs2 ablation i...
- Ergosterol Regulates Sterol Regulatory Element Binding Protein (SREBP) Cleavage in Fission Yeast
[作者:Porter, JR; Burg, JS; Espenshade, PJ; Iglesias, PA,期刊:Journal of Biological Chemistry, 页码:U161-U168 , 文章类型: Article,,卷期:2010年285-52]
- In fission yeast, the endoplasmic reticulum membrane-bound proteins Sre1 and Scp1, orthologs of mammalian sterol regulatory element binding protein (SREBP) and Scap, monitor sterol synthesis as an indirect measure of oxy...
- A Phosphorylation Switch Regulates the Transcriptional Activation of Cell Cycle Regulator p21 by Histone Deacetylase Inhibitors
[作者:Simboeck, E; Sawicka, A; Zupkovitz, G; Senese, S; Winter, S; Dequiedt, F; Ogris, E; Di Croce, L; Chiocca, S; Seiser, C,期刊:Journal of Biological Chemistry, 页码:U161-U168 , 文章类型: Article,,卷期:2010年285-52]
- Histone deacetylase inhibitors induce cell cycle arrest and apoptosis in tumor cells and are, therefore, promising anticancer drugs. The cyclin-dependent kinase inhibitor p21 is activated in histone deacetylase (HDAC) in...
- Both Thioredoxin 2 and Glutaredoxin 2 Contribute to the Reduction of the Mitochondrial 2-Cys Peroxiredoxin Prx3
[作者:Hanschmann, EM; Lonn, ME; Schutte, LD; Funke, M; Godoy, JR; Eitner, S; Hudemann, C; Lillig, CH,期刊:Journal of Biological Chemistry, 页码:U161-U168 , 文章类型: Article,,卷期:2010年285-52]
- The proteins from the thioredoxin family are crucial actors in redox signaling and the cellular response to oxidative stress. The major intracellular source for oxygen radicals are the components of the respiratory chain...
- Hepatitis B Virus Induces Expression of Antioxidant Response Element-regulated Genes by Activation of Nrf2
[作者:Schaedler, S; Krause, J; Himmelsbach, K; Carvajal-Yepes, M; Lieder, F; Klingel, K; Nassal, M; Weiss, TS; Werner, S; Hildt, E,期刊:Journal of Biological Chemistry, 页码:U161-U168 , 文章类型: Article,,卷期:2010年285-52]
- The expression of a variety of cytoprotective genes is regulated by short cis-acting elements in their promoters, called antioxidant response elements (AREs). A central regulator of ARE-mediated gene expression is the NF...
- Extended Binding Site on Fibronectin for the Functional Upstream Domain of Protein F1 of Streptococcus pyogenes
[作者:Maurer, LM; Tomasini-Johansson, BR; Ma, WJ; Annis, DS; Eickstaedt, NL; Ensenberger, MG; Satyshur, KA; Mosher, DF,期刊:Journal of Biological Chemistry, 页码:U161-U168 , 文章类型: Article,,卷期:2010年285-52]
- The 49-residue functional upstream domain (FUD) of Streptococcus pyogenes F1 adhesin interacts with fibronectin (FN) in a heretofore unknown manner that prevents assembly of a FN matrix. Biotinylated FUD (b-FUD) bound to...
- Molecular Association of the Arabidopsis ETR1 Ethylene Receptor and a Regulator of Ethylene Signaling, RTE1
[作者:Dong, CH; Jang, M; Scharein, B; Malach, A; Rivarola, M; Liesch, J; Groth, G; Hwang, I; Chang, C,期刊:Journal of Biological Chemistry, 页码:U161-U168 , 文章类型: Article,,卷期:2010年285-52]
- The plant hormone ethylene plays important roles in growth and development. Ethylene is perceived by a family of membrane-bound receptors that actively repress ethylene responses. When the receptors bind ethylene, their ...
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