- Prospecting Metagenomic Enzyme Subfamily Genes for DNA Family Shuffling by a Novel PCR-based Approach
[作者:Wang, QY; Wu, HL; Wang, AM; Du, PF; Pei, XL; Li, HF; Yin, XP; Huang, LF; Xiong, XL,期刊:Journal of Biological Chemistry, 页码:41509-41516 , 文章类型: Article,,卷期:2010年285-53]
- DNA family shuffling is a powerful method for enzyme engineering, which utilizes recombination of naturally occurring functional diversity to accelerate laboratory-directed evolution. However, the use of this technique h...
- Identification of Low Molecular Weight Pyroglutamate A beta Oligomers in Alzheimer Disease A NOVEL TOOL FOR THERAPY AND DIAGNOSIS
[作者:Wirths, O; Erck, C; Martens, H; Harmeier, A; Geumann, C; Jawhar, S; Kumar, S; Multhaup, G; Walter, J; Ingelsson, M; Degerman-Gunnarsson, M; Kalimo, H; Huitinga, I; Lannfelt, L; Bayer, TA,期刊:Journal of Biological Chemistry, 页码:41517-41524 , 文章类型: Article,,卷期:2010年285-53]
- N-terminally truncated A beta peptides starting with pyroglutamate (A beta pE3) represent a major fraction of all A beta peptides in the brain of Alzheimer disease (AD) patients. A beta pE3 has a higher aggregation prope...
- Identification of the NC1 Domain of alpha 3 Chain as Critical for alpha 3 alpha 4 alpha 5 Type IV Collagen Network Assembly
[作者:LeBleu, V; Sund, M; Sugimoto, H; Birrane, G; Kanasaki, K; Finan, E; Miller, CA; Gattone, VH; McLaughlin, H; Shield, CF; Kalluri, R,期刊:Journal of Biological Chemistry, 页码:41874-41885 , 文章类型: Article,,卷期:2010年285-53]
- The network organization of type IV collagen consisting of alpha 3, alpha 4, and alpha 5 chains in the glomerular basement membrane (GBM) is speculated to involve interactions of the triple helical and NC1 domain of indi...
- The Anti-angiogenic Peptide, Loop 6, Binds Insulin-like Growth Factor-1 Receptor
[作者:Fernandez, CA; Roy, R; Lee, S; Yang, JA; Panigrahy, D; Van Vliet, KJ; Moses, MA,期刊:Journal of Biological Chemistry, 页码:41886-41895 , 文章类型: Article,,卷期:2010年285-53]
- Tissue inhibitors of metalloproteinases (TIMPs), the endogenous inhibitors of matrix metalloproteinases, have been shown to possess biological functions that are independent of their ability to inhibit matrix metalloprot...
- GRK5 Deficiency Accelerates beta-Amyloid Accumulation in Tg2576 Mice via Impaired Cholinergic Activity
[作者:Cheng, SW; Li, LX; He, ST; Liu, J; Sun, YN; He, MC; Grasing, K; Premont, RT; Suo, WZ,期刊:Journal of Biological Chemistry, 页码:41541-41548 , 文章类型: Article,,卷期:2010年285-53]
- Membrane G protein-coupled receptor kinase 5 (GRK5) deficiency is linked to Alzheimer disease, yet its precise roles in the disease pathogenesis remain to be delineated. We have previously demonstrated that GRK5 deficien...
- Neuropeptide Y Modulation of Interleukin-1 beta (IL-1 beta)-induced Nitric Oxide Production in Microglia
[作者:Ferreira, R; Xapelli, S; Santos, T; Silva, AP; Cristovao, A; Cortes, L; Malva, JO,期刊:Journal of Biological Chemistry, 页码:41921-41934 , 文章类型: Article,,卷期:2010年285-53]
- Given the modulatory role of neuropeptide Y (NPY) in the immune system, we investigated the effect of NPY on the production of NO and IL-1 beta in microglia. Upon LPS stimulation, NPY treatment inhibited NO production as...
- Response to Falk and Sinning: The C Terminus of Alb3 Interacts with the Chromodomains 2 and 3 of cpSRP43
[作者:Lewis, NE; Kight, AD; Daily, A; Kumar, TKS; Henry, RL; Goforth, RL,期刊:Journal of Biological Chemistry, 页码:LE26-LE28 , 文章类型: Letter,,卷期:2010年285-53]
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