- A Novel 3-Methylhistidine Modification of Yeast Ribosomal Protein Rpl3 Is Dependent upon the YIL110W Methyltransferase
[作者:Webb, KJ; Zurita-Lopez, CI; Al-Hadid, Q; Laganowsky, A; Young, BD; Lipson, RS; Souda, P; Faull, KF; Whitelegge, JP; Clarke, SG,期刊:Journal of Biological Chemistry, 页码:37598-37606 , 文章类型: Article,,卷期:2010年285-48]
- We have shown that Rpl3, a protein of the large ribosomal subunit from baker's yeast (Saccharomyces cerevisiae), is stoichiometrically monomethylated at position 243, producing a 3-methylhistidine residue. This conclusio...
- Dual Modes of Interaction between XRCC4 and Polynucleotide Kinase/Phosphatase IMPLICATIONS FOR NONHOMOLOGOUS END JOINING
[作者:Mani, RS; Yu, YP; Fang, SJ; Lu, ML; Fanta, M; Zolner, AE; Tahbaz, N; Ramsden, DA; Litchfield, DW; Lees-Miller, SP; Weinfeld, M,期刊:Journal of Biological Chemistry, 页码:37619-37629 , 文章类型: Article,,卷期:2010年285-48]
- XRCC4 plays a crucial role in the nonhomologous end joining (NHEJ) pathway of DNA double-strand break repair acting as a scaffold protein that recruits other NHEJ proteins to double-strand breaks. Phosphorylation of XRCC...
- Identification of a Lysosomal Pathway Regulating Degradation of the Bone Morphogenetic Protein Receptor Type II
[作者:Durrington, HJ; Upton, PD; Hoer, S; Boname, J; Dunmore, BJ; Yang, J; Crilley, TK; Butler, LM; Blackbourn, DJ; Nash, GB; Lehner, PJ; Morrell, NW,期刊:Journal of Biological Chemistry, 页码:37641-37649 , 文章类型: Article,,卷期:2010年285-48]
- Bone morphogenetic proteins (BMPs) are critically involved in early development and cell differentiation. In humans, dysfunction of the bone morphogenetic protein type II receptor (BMPR-II) is associated with pulmonary a...
- Optimization of the Degenerated Interfacial ATP Binding Site Improves the Function of Disease-related Mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Channels
[作者:Tsai, MF; Jih, KY; Shimizu, H; Li, M; Hwang, TC,期刊:Journal of Biological Chemistry, 页码:37663-37671 , 文章类型: Article,,卷期:2010年285-48]
- The cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel, an ATP binding cassette (ABC) protein whose defects cause the deadly genetic disease cystic fibrosis (CF), encompasses two nucleotide bindi...
- The MBT Repeats of L3MBTL1 Link SET8-mediated p53 Methylation at Lysine 382 to Target Gene Repression
[作者:West, LE; Roy, S; Lachmi-Weiner, K; Hayashi, R; Shi, XB; Appella, E; Kutateladze, TG; Gozani, O,期刊:Journal of Biological Chemistry, 页码:37725-37732 , 文章类型: Article,,卷期:2010年285-48]
- The p53 tumor suppressor protein is regulated by multiple post-translational modifications, including lysine methylation. We previously found that monomethylation of p53 at lysine 382 (p53K382me1) by the protein lysine m...
- Methylation of the Retinoblastoma Tumor Suppressor by SMYD2
[作者:Saddic, LA; West, LE; Aslanian, A; Yates, JR; Rubin, SM; Gozani, O; Sage, J,期刊:Journal of Biological Chemistry, 页码:37733-37740 , 文章类型: Article,,卷期:2010年285-48]
- The retinoblastoma tumor suppressor (RB) is a central cell cycle regulator and tumor suppressor. RB cellular functions are known to be regulated by a diversity of post-translational modifications such as phosphorylation ...
- Acceptor Substrate Discrimination in Phosphatidyl-myo-inositol Mannoside Synthesis STRUCTURAL AND MUTATIONAL ANALYSIS OF MANNOSYLTRANSFERASE CORYNEBACTERIUM GLUTAMICUM PimB '
[作者:Batt, SM; Jabeen, T; Mishra, AK; Veerapen, N; Krumbach, K; Eggeling, L; Besra, GS; Futterer, K,期刊:Journal of Biological Chemistry, 页码:37741-37752 , 文章类型: Article,,卷期:2010年285-48]
- Long term survival of the pathogen Mycobacterium tuberculosis in humans is linked to the immunomodulatory potential of its complex cell wall glycolipids, which include the phosphatidylinositol mannoside (PIM) series as w...
- Experimental Validation of the Predicted Binding Site of Escherichia coli K1 Outer Membrane Protein A to Human Brain Microvascular Endothelial Cells IDENTIFICATION OF CRITICAL MUTATIONS THAT PREVENT E. COLI MENINGITIS
[作者:Pascal, TA; Abrol, R; Mittal, R; Wang, Y; Prasadarao, NV; Goddard, WA,期刊:Journal of Biological Chemistry, 页码:37753-37761 , 文章类型: Article,,卷期:2010年285-48]
- Escherichia coli K1, the most common cause of meningitis in neonates, has been shown to interact with GlcNAc1-4GlcNAc epitopes of Ecgp96 on human brain microvascular endothelial cells (HBMECs) via OmpA (outer membrane pr...
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