- Clustered hydrophobic amino acids in amphipathic helices mediate erlin1/2 complex assembly
[作者:Pednekar, D; Wang, Y; Fedotova, TV; Wojcikiewicz, RJH,期刊:Biochemical and Biophysical Research Communications, 页码:135-140 , 文章类型: Article,,卷期:2011年415-1]
- Erlin1 and erlin2 are highly homologous, similar to 40 kDa, endoplasmic reticulum membrane proteins that assemble into a ring-shaped complex with a mass of similar to 2 MDa. How this complex is formed is not understood, ...
- A mechanism underlying compound-induced voltage shift in the current activation of hERG by antiarrhythmic agents
[作者:Furutani, K; Yamakawa, Y; Inanobe, A; Iwata, M; Ohno, Y; Kurachi, Y,期刊:Biochemical and Biophysical Research Communications, 页码:141-146 , 文章类型: Article,,卷期:2011年415-1]
- Nifekalant and azimilide, Class III antiarrhythmic agents, block the human ether-a-go-go-related gene le (hERG) channel. However, when a depolarizing membrane potential is applied, they also increase the current at low p...
- Augmenter of liver regeneration (ALR) gene therapy attenuates CCl(4)-induced liver injury and fibrosis in rats
[作者:Song, M; Yi, XR; Chen, WY; Yuan, YC; Zhang, XR; Li, J; Tong, MH; Liu, GZ; You, S; Kong, XP,期刊:Biochemical and Biophysical Research Communications, 页码:152-156 , 文章类型: Article,,卷期:2011年415-1]
- Liver fibrosis represents a process of healing and scarring in response to chronic liver injury. Augmenter of liver regeneration (ALR) has been shown to protect hepatocytes from various toxins. The aim of this study was ...
- Protein kinase CK2 modulates IL-6 expression in inflammatory breast cancer
[作者:Drygin, D; Ho, CB; Omori, M; Bliesath, J; Proffitt, C; Rice, R; Siddiqui-Jain, A; O'Brien, S; Padgett, C; Lim, JKC; Anderes, K; Rice, WG; Ryckman, D,期刊:Biochemical and Biophysical Research Communications, 页码:163-167 , 文章类型: Article,,卷期:2011年415-1]
- Inflammatory breast cancer is driven by pro-angiogenic and pro-inflammatory cytokines. One of them Interleukin-6 (IL-6) is implicated in cancer cell proliferation and survival, and promotes angiogenesis, inflammation and...
- G(s) and G(q) signalings regulate hPEM-2-induced cell responses in Neuro-2a cells
[作者:Nagae, R; Sato, K; Yasui, Y; Banno, Y; Nagase, T; Ueda, H,期刊:Biochemical and Biophysical Research Communications, 页码:168-173 , 文章类型: Article,,卷期:2011年415-1]
- Rho family GTPase-specific guanine nucleotide exchange factors of the Dbl family regulate a variety of cellular events including cytoskeletal arrangement, signal transduction, and gene expression through activation of Rh...
- Inverted repeats in the promoter as an autoregulatory sequence for TcrX in Mycobacterium tuberculosis
[作者:Bhattacharya, M; Das, AK,期刊:Biochemical and Biophysical Research Communications, 页码:17-23 , 文章类型: Article,,卷期:2011年415-1]
- TcrY, a histidine kinase, and TcrX, a response regulator, constitute a two-component system in Mycobacterium tuberculosis, tcrX, which is expressed during iron scarcity, is instrumental in the survival of iron-dependent ...
- 2-Methoxycinnamaldehyde inhibits tumor angiogenesis by suppressing Tie2 activation
[作者:Yamakawa, D; Kidoya, H; Sakimoto, S; Jia, WZ; Takakura, N,期刊:Biochemical and Biophysical Research Communications, 页码:174-180 , 文章类型: Article,,卷期:2011年415-1]
- Blood vessels are mainly composed of intraluminal endothelial cells (ECs) and mural cells adhering to the ECs on their basal side. Immature blood vessels lacking mural cells are leaky; thus, the process of mural cell adh...
- Inhibition of autophagy stimulate molecular iodine-induced apoptosis in hormone independent breast tumors
[作者:Singh, P; Godbole, M; Rao, G; Annarao, S; Mitra, K; Roy, R; Ingle, A; Agarwal, G; Tiwari, S,期刊:Biochemical and Biophysical Research Communications, 页码:181-186 , 文章类型: Article,,卷期:2011年415-1]
- Estrogen receptor negative (ER(-ve)) and p53 mutant breast tumors are highly aggressive and have fewer treatment options. Previously, we showed that molecular Iodine (I(2)) induces apoptosis in hormone responsive MCF-7 b...
- Proteasome inhibitor lactacystin augments natural killer cell cytotoxicity of myeloma via downregulation of HLA class I
[作者:Wu, XS; Shao, Y; Tao, Y; Ai, GW; Wei, R; Meng, XQ; Hou, J; Han, Y; Zhan, FH; Zheng, JH; Shi, JM,期刊:Biochemical and Biophysical Research Communications, 页码:187-192 , 文章类型: Article,,卷期:2011年415-1]
- Modulation of inhibitory and activating natural killer (NK) receptor ligands on tumor cells represents a promising therapeutic approach against cancer, including multiple myeloma (MM). Human leukocyte antigen (HLA) class...
- Characterization of marine X-family DNA polymerases and comparative analysis of base excision repair proteins
[作者:Kodera, H; Takeuchi, R; Uchiyama, Y; Takakusagi, Y; Iwabata, K; Miwa, H; Hanzawa, N; Sugawara, F; Sakaguchi, K,期刊:Biochemical and Biophysical Research Communications, 页码:193-199 , 文章类型: Article,,卷期:2011年415-1]
- While mammalian DNA polymerase beta (Pol beta), which is a member of the Pol X family, play important roles in base excision repair (BER) that efficiently removes DNA base lesions arising from both endogenous and exogeno...
- Suppression of lipin-1 expression increases monocyte chemoattractant protein-1 expression in 3T3-L1 adipocytes
[作者:Takahashi, N; Yoshizaki, T; Hiranaka, N; Suzuki, T; Yui, T; Akanuma, M; Oka, K; Kanazawa, K; Yoshida, M; Naito, S; Fujiya, M; Kohgo, Y; Ieko, M,期刊:Biochemical and Biophysical Research Communications, 页码:200-205 , 文章类型: Article,,卷期:2011年415-1]
- Lipin-1 plays a crucial role in the regulation of lipid metabolism and cell differentiation in adipocytes. Expression of adipose lipin-1 is reduced in obesity, and metabolic syndrome. However, the significance of this re...
- Adaptor protein containing PH domain, PTB domain and leucine zipper (APPL1) regulates the protein level of EGFR by modulating its trafficking
[作者:Lee, JR; Hahn, HS; Kim, YH; Nguyen, HH; Yang, JM; Kang, JS; Hahn, MJ,期刊:Biochemical and Biophysical Research Communications, 页码:206-211 , 文章类型: Article,,卷期:2011年415-1]
- The EGFR-mediated signaling pathway regulates multiple biological processes such as cell proliferation, survival and differentiation. Previously APPL1 (adaptor protein containing PH domain, PTB domain and leucine zipper ...
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