- Glial fibrillary acidic protein is elevated in the lysosomal storage disease classical late-infantile neuronal ceroid lipofuscinosis, but is not a component of the storage material
[作者:Xu, S; Sleat, DE; Jadot, M; Lobel, P,期刊:Biochemical Journal, 页码:355-362 , 文章类型: Article,,卷期:2010年428-Part 3]
- Classical late-infantile neuronal ceroid lipofuscinosis (LINCL) is a fatal neurodegenerative disease of children caused by mutations in TPP1, the gene encoding the lysosomal protease tripeptidyl peptidase I. LINCL is cha...
- Novel insights into the assembly and function of human nuclear-encoded cytochrome c oxidase subunits 4, 5a, 6a, 7a and 7b
[作者:Fornuskova, D; Stiburek, L; Wenchich, L; Vinsova, K; Hansikova, H; Zeman, J,期刊:Biochemical Journal, 页码:363-374 , 文章类型: Article,,卷期:2010年428-Part 3]
- Mammalian CcO (cytochrome c oxidase) is a hetero-oligomeric protein complex composed of 13 structural subunits encoded by both the mitochondrial and nuclear genomes. To study the role of nuclear-encoded CcO subunits in t...
- Phosphorylation of Ser(136) is critical for potent bone sialoprotein-mediated nucleation of hydroxyapatite crystals
[作者:Baht, GS; O'Young, J; Borovina, A; Chen, H; Tye, CE; Karttunen, M; Lajoie, GA; Hunter, GK; Goldberg, HA,期刊:Biochemical Journal, 页码:385-395 , 文章类型: Article,,卷期:2010年428-Part 3]
- Acidic phosphoproteins of mineralized tissues such as bone and dentin are believed to play important roles in HA (hydroxyapatite) nucleation and growth. BSP (bone sialoprotein) is the most potent known nucleator of HA, a...
- A novel HPLC-based approach makes possible the spatial characterization of cellular PtdIns5P and other phosphoinositides
[作者:Sarkes, D; Rameh, LE,期刊:Biochemical Journal, 页码:375-384 , 文章类型: Article,,卷期:2010年428-Part 3]
- PtdIns5P was discovered in 1997 [Rameh, Tolias, Duckworth and Cantley (1997) Nature 390, 192-196], but still very little is known about its regulation and function. Hitherto, studies of PtdIns5P regulation have been hind...
- Lipid remodelling of glycosylphosphatidylinositol (GPI) glycoconjugates in procyclic-form trypanosomes: biosynthesis and processing of GPIs revisited
[作者:Butikofer, P; Greganova, E; Liu, YC; Edwards, IJ; Lehane, MJ; Acosta-Serrano, A,期刊:Biochemical Journal, 页码:409-418 , 文章类型: Article,,卷期:2010年428-Part 3]
The African trypanosome, Trypanosoma brucei, has been used as a model to study the biosynthesis of GPI (glycosylphosphatidylinositol) anchors. In mammalian (bloodstream)-form parasites, diacyl-type GPI precursors are ...
- Renal imino acid and glycine transport system ontogeny and involvement in developmental iminoglycinuria
[作者:Vanslambrouck, JM; Broer, A; Thavyogarajah, T; Holst, J; Bailey, CG; Broer, S; Rasko, JEJ,期刊:Biochemical Journal, 页码:397-407 , 文章类型: Article,,卷期:2010年428-Part 3]
- Renal maturation occurs post-natally in many species and reabsorption capacity at birth can vary substantially from the mature kidney. However, little is known regarding the maturation of amino acid transport mechanisms,...
- T-cell receptor early signalling complex activation in response to interferon-alpha receptor stimulation
[作者:Stevens, CN; Simeone, AM; John, S; Ahmed, Z; Lucherini, OM; Baldari, CT; Ladbury, JE,期刊:Biochemical Journal, 页码:429-437 , 文章类型: Article,,卷期:2010年428-Part 3]
- Signalling through the IFN alpha R (interferon-alpha receptor) and TCR (T-cell receptor) in Jurkat T lymphocytes results in distinct immune responses. Despite this both receptors elicit ERK (extracellular-signal-regulate...
- S-Glutathionyl-(chloro)hydroquinone reductases: a novel class of glutathione transferases
[作者:Xun, LY; Belchik, SM; Xun, R; Huang, Y; Zhou, HN; Sanchez, E; Kang, C; Board, PG,期刊:Biochemical Journal, 页码:419-427 , 文章类型: Article,,卷期:2010年428-Part 3]
- Sphingobium chlorophenolicum completely mineralizes PCP (pentachlorophenol). Two GSTs (glutathione transferases), PcpC and PcpF, are involved in the degradation. PcpC uses GSH to reduce TeCH (tetrachloro-p-hydroquinone) ...
- Thiol isomerases negatively regulate the cellular shedding activity of ADAM17
[作者:Willems, SH; Tape, CJ; Stanley, PL; Taylor, NA; Mills, IG; Neal, DE; McCafferty, J; Murphy, G,期刊:Biochemical Journal, 页码:439-450 , 文章类型: Article,,卷期:2010年428-Part 3]
- ADAM17 (where ADAM is 'a disintegrin and metalloproteinase') can rapidly modulate cell-surface signalling events by the proteolytic release of soluble forms of proligands for cellular receptors. Many regulatory pathways ...
- Nitric oxide triggers mammary gland involution after weaning: remodelling is delayed but not impaired in mice lacking inducible nitric oxide synthase
[作者:Zaragoza, R; Bosch, A; Garcia, C; Sandoval, J; Serna, E; Torres, L; Garcia-Trevijano, ER; Vina, JR,期刊:Biochemical Journal, 页码:451-462 , 文章类型: Article,,卷期:2010年428-Part 3]
- During mammary gland involution, different signals are required for apoptosis and tissue remodelling. To explore the role of NO in the involution of mammary tissue after lactation, NOS2 (inducible nitric oxide synthase)-...
- Biosynthesis of heparan sulfate in EXT1-deficient cells
[作者:Okada, M; Nadanaka, S; Shoji, N; Tamura, J; Kitagawa, H,期刊:Biochemical Journal, 页码:463-471 , 文章类型: Article,,卷期:2010年428-Part 3]
HS (heparan sulfate) is synthesized by HS co-polymerases encoded by the EXT1 and EXT2 genes (exostosin 1 and 2), which are known as causative genes for hereditary multiple exostoses, a dominantly inherited genetic dis...
- Activation of human pro-urokinase by unrelated proteases secreted by Pseudomonas aeruginosa
[作者:Beaufort, N; Seweryn, P; de Bentzmann, S; Tang, AH; Kellermann, J; Grebenchtchikov, N; Schmitt, M; Sommerhoff, CP; Pidard, D; Magdolen, V,期刊:Biochemical Journal, 页码:473-482 , 文章类型: Article,,卷期:2010年428-Part 3]
- Pathogenic bacteria, including Pseudomonas aeruginosa, interact with and engage the host plasminogen (Pig) activation system, which encompasses the urokinase (uPA)-type Pig activator, and is involved in extracellular pro...
- Cellular nucleic-acid-binding protein, a transcriptional enhancer of c-Myc, promotes the formation of parallel G-quadruplexes
[作者:Borgognone, M; Armas, P; Calcaterra, NB,期刊:Biochemical Journal, 页码:491-498 , 文章类型: Article,,卷期:2010年428-Part 3]
- G-rich sequences that contain stretches of tandem guanines can form four-stranded, intramolecular stable DNA structures called G-quadruplexes (termed G4s). Regulation of the equilibrium between single-stranded and G4 DNA...
- Three-dimensional structure of recombinant type 1 inositol 1,4,5-trisphosphate receptor
[作者:Wolfram, F; Morris, E; Taylor, CW,期刊:Biochemical Journal, 页码:483-489 , 文章类型: Article,,卷期:2010年428-Part 3]
- IP(3)Rs (inositol 1,4,5-trisphosphate receptors) are the intracellular channels that mediate release of Ca2+ from the endoplasmic reticulum in response to the many stimuli that evoke Ins(1,4,5)P-3 formation. We character...
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