- Insights into the substrate specificity of plant peptide deformylase, an essential enzyme with potential for the development of novel biotechnology applications in agriculture
[作者:Dirk, LMA; Schmidt, JJ; Cai, Y; Barnes, JC; Hanger, KM; Nayak, NR; Williams, MA; Grossman, RB; Houtz, RL; Rodgers, DW,期刊:Biochemical Journal, 页码:417-427 , 文章类型: Article,,卷期:2008年413-3]
- The crystal structure of AtPDF1B [Arabidopsis thaliana PDF (peptide deformylase) 1B; EC 3.5.1.88], a plant specific deformylase, has been determined at a resolution of 2.4 angstrom (1 angstrom=0.1 nm). The overall fold o...
- High Cu(I) and low proton affinities of the CXXC motif of Bacillus subtilis CopZ
[作者:Zhou, L; Singleton, C; Le Brun, NE,期刊:Biochemical Journal, 页码:459-465 , 文章类型: Article,,卷期:2008年413-3]
- CopZ, an Atx I-like copper chaperone from the bacterium Bacillus subtilis, functions as part of a complex cellular machinery for Cu(I) trafficking and detoxification, in which it interacts specifically with the transmemb...
- Endosomal compartment contributes to the propagation of CD95/Fas-mediated signals in type II cells
[作者:Matarrese, P; Manganelli, V; Garofalo, T; Tinari, A; Gambardella, L; Ndebele, K; Khosravi-Far, R; Soricie, M; Espost, MD; Malorni, W,期刊:Biochemical Journal, 页码:467-478 , 文章类型: Article,,卷期:2008年413-3]
- Participation of diverse organelles in the intracellular signalling that follows CD95/Fas receptor ligation encompasses a series of subcellular changes that are mandatory for, or even bolster, the apoptotic cascade. In t...
- S-nitrosylation of syntaxin 1 at Cys(145) is a regulatory switch controlling Munc18-1 binding
[作者:Palmer, ZJ; Duncan, RR; Johnson, JR; Lian, LY; Mello, LV; Booth, D; Barclay, JW; Graham, ME; Burgoyne, RD; Prior, IA; Morgan, A,期刊:Biochemical Journal, 页码:479-491 , 文章类型: Article,,卷期:2008年413-3]
- Exocytosis is regulated by NO in many cell types, including neurons. In the present study we show that syntaxin la is a substrate for S-nitrosylation and that NO disrupts the binding of Munc18-1 to the closed conformatio...
- Reduction of S-nitrosoglutathione by alcohol dehydrogenase 3 is facilitated by substrate alcohols via direct cofactor recycling and leads to GSH-controlled formation of glutathione transferase inhibitors
[作者:Staab, CA; Alander, J; Brandt, M; Lengqvist, J; Morgenstern, R; Grafstrom, RC; Hoog, JO,期刊:Biochemical Journal, 页码:493-504 , 文章类型: Article,,卷期:2008年413-3]
- GSNO (S-nitrosoglutathione) is emerging as a key regulator in NO signalling as it is in equilibrium with S-nitrosated proteins. Accordingly, it is of great interest to investigate GSNO metabolism in terms of competitive ...
- Association of human DNA helicase RecQ5 beta with RNA polymerase II and its possible role in transcription
[作者:Izumikawa, K; Yanagida, M; Hayano, T; Tachikawa, H; Komatsu, W; Shimamoto, A; Futami, K; Furuichi, Y; Shinkawa, T; Yamauchi, Y; Isobe, T; Takahashi, N,期刊:Biochemical Journal, 页码:505-516 , 文章类型: Article,,卷期:2008年413-3]
- Although RecQ5 beta is a ssDNA (single-stranded DNA)-stimulated ATPase and an ATP-dependent DNA helicase with strand-annealing activities, its cellular function remains to be explored. In the present paper, we used immun...
- Elimination of competing hydrolysis and coupling side reactions of a cyclodextrin glucanotransferase by directed evolution
[作者:Kelly, RM; Leemhuis, H; Rozeboom, HJ; van Oosterwijk, N; Dijkstra, BW; Dijkhuizen, L,期刊:Biochemical Journal, 页码:517-525 , 文章类型: Article,,卷期:2008年413-3]
- Thermoanaerobacterium thermosulfurigenes cyclodextrin glucanotransferase primarily catalyses the formation of cyclic alpha-(1,4)-linked oligosaccharides (cyclodextrins) from starch. This enzyme also possesses unusually h...
- Analysis of mutant origin recognition complex with reduced ATPase activity in vivo and in vitro
[作者:Takehara, M; Makise, M; Takenaka, H; Asano, T; Mizushima, T,期刊:Biochemical Journal, 页码:535-543 , 文章类型: Article,,卷期:2008年413-3]
- In eukaryotes, ORC (origin recognition complex), a six-protein complex, is the most likely initiator of chromosomal DNA replication. ORC belongs to the AAA(+) (ATPases associated with a variety of cellular activities) fa...
- Proteomic analysis of polymeric salivary mucins: no evidence for MUC19 in human saliva
[作者:Rousseau, K; Kirkham, S; Johnson, L; Fitzpatrick, B; Howard, M; Adams, EJ; Rogers, DF; Knight, D; Clegg, P; Thornton, DJ,期刊:Biochemical Journal, 页码:545-552 , 文章类型: Article,,卷期:2008年413-3]
- MUC5B is the predominant polymeric mucin in human saliva [Thornton, Khan, Mehrotra, Howard, Veerman, Packer and Sheehan (1999) Glycobiology 9, 293-302], where it contributes to oral cavity hydration and protection. More ...
- Identification of an iron-hepcidin complex
[作者:Farnaud, S; Rapisarda, C; Bui, T; Drake, A; Cammack, R; Evans, RW,期刊:Biochemical Journal, 页码:553-557 , 文章类型: Article,,卷期:2008年413-3]
- Following its identification as a liver-expressed antimicrobial peptide, the hepcidin peptide was later shown to be a key player in iron homoeostasis. It is now proposed to be the 'iron hormone' which, by interacting wit...
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