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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共16条记录   Apoptotic sensitivity of murine IAP-deficient cells [作者：Rumble, JM; Bertrand, MJM; Csomos, RA; Wright, CW; Albert, L; Mak, TW; Barker, PA; Duckett, CS,期刊：Biochemical Journal, 页码：21-25 , 文章类型： Article，,卷期：2008年415-1] Although numerous studies have implicated the IAPs (inhibitor of apoptosis proteins) in the control of apaptotic cell death, analyses of murine lap-targeted cells have not revealed significant differences in their suscep... Ability of PknA, a mycobacterial eukaryotic-type serine/threonine kinase, to transphosphorylate MurD, a ligase involved in the process of peptidoglycan biosynthesis [作者：Thakur, M; Chakraborti, PK,期刊：Biochemical Journal, 页码：27-33 , 文章类型： Article，,卷期：2008年415-1] Eukaryotic-type serine/threonine protein kinases in bacteria have been implicated in controlling a host of cellular activities. PknA is one of eleven - Such protein kinases from Mycobacterium tuberculosis which regulates... Prohormone convertases 1/3 and 2 together orchestrate the site-specific cleavages of progastrin to release gastrin-34 and gastrin-17 [作者：Rehfeld, JF; Zhu, X; Norrbom, C; Bundgaard, JR; Johnsen, AH; Nielsen, JE; Vikesaa, J; Stein, J; Dey, A; Steiner, DF; Friis-Hansen, L,期刊：Biochemical Journal, 页码：35-43 , 文章类型： Article，,卷期：2008年415-1] Cellular synthesis of peptide hormones requires PCs (prohormone convertases) for the endoproteolysis of prohormones. Antral G-cells synthesize the most gastrin and express PC1/3, 2 and 5/6 in the rat and human. But the c... Molecular basis of the substrate specificity and the catalytic mechanism of citramalate synthase from Leptospira interrogans [作者：Ma, J; Zhang, P; Zhang, ZL; Zha, MW; Xu, H; Zhao, GP; Ding, JP,期刊：Biochemical Journal, 页码：45-56 , 文章类型： Article，,卷期：2008年415-1] Leptospira interrogans is the causative agent for leptospirosis, a zoonotic disease of global importance. In contrast with most other micro-organisms, L. interrogans employs a pyruvate pathway to synthesize isoleucine an... Activation of NADPH oxidase 1 in tumour colon epithelial cells [作者：Nisimoto, Y; Tsubouchi, R; Diebold, BA; Qiao, SL; Ogawa, H; Ohara, T; Tamura, M,期刊：Biochemical Journal, 页码：57-65 , 文章类型： Article，,卷期：2008年415-1] In the plasma membrane fraction from Caco-2 human colon carcinoma cells, active Nox1 (NADPH oxidase 1) endogenously co-localizes with its regulatory components p22(phox), NOXO1, NOXA1 and Rac1. NADPH-specific superoxide ... Rab geranylgeranylation occurs preferentially via the pre-formed REP-RGGT complex and is regulated by geranylgeranyl pyrophosphate [作者：Baron, RA; Seabra, MC,期刊：Biochemical Journal, 页码：67-75 , 文章类型： Article，,卷期：2008年415-1] Prenylation (or geranylgeranylation) of Rab GTPases is catalysed by RGGT (Rab geranylgeranyl transferase) and requires REP (Rab escort protein). In the classical pathway, REP associates first with unprenylated Rab, which... PKC beta II modulates translation independently from mTOR and through RACK1 [作者：Grosso, S; Volta, V; Sala, LA; Vietri, M; Marchisio, PC; Ron, D; Biffo, S,期刊：Biochemical Journal, 页码：77-85 , 文章类型： Article，,卷期：2008年415-1] RACK1 (receptor for activated C kinase 1) is an abundant scaf-folding protein, which binds active PKC beta II (protein kinase C beta II) increasing its activity in vitro. RACK1 has also been described as a component of t... Lipidomic analysis of Toxoplasma gondii tachyzoites rhoptries: further insights into the role of cholesterol [作者：Besteiro, S; Bertrand-Michel, J; Lebrun, M; Vial, H; Dubremetz, JF,期刊：Biochemical Journal, 页码：87-96 , 文章类型： Article，,卷期：2008年415-1] Rhoptries are secretory organelles involved in the virulence of the human pathogen Toxoplasma gondii. In the present study we have used HPLC and capillary GLC to isolate and quantify lipids front whole Toxoplasma cells a... A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition [作者：Torbett, NE; Luna-Moran, A; Knight, ZA; Houk, A; Moasser, M; Weiss, W; Shokat, KM; Stokoe, D,期刊：Biochemical Journal, 页码：97-110 , 文章类型： Article，,卷期：2008年415-1] The PI3K (phosphoinositide 3-kinase) pathway regulates cell proliferation, Survival and migration and is consequently of great interest for targeted cancer therapy. Using a panel of small-molecule PI3K isoform-selective ... Down-regulation of hepatic nuclear factor 4 alpha on expression of human hepatic stimulator substance via its action on the proximal promoter in HepG2 cells [作者：Guo, D; Dong, LY; Wu, YA; Yang, L; An, W,期刊：Biochemical Journal, 页码：111-121 , 文章类型： Article，,卷期：2008年415-1] hHSS (human hepatic stimulator substance) stimulates hepatocyte growth. To understand the mechanism controlling hHSS expression, we analysed the proximal promoter activity and identified two regulatory regions (-212/-192... Transaldolase deficiency influences the pentose phosphate pathway, mitochondrial homoeostasis and apoptosis signal processing [作者：Qian, YM; Banerjee, S; Grossman, CE; Amidon, W; Nagy, G; Barcza, M; Niland, B; Karp, DR; Middleton, FA; Banki, K; Perl, A,期刊：Biochemical Journal, 页码：123-134 , 文章类型： Article，,卷期：2008年415-1] TAL (transaldolase) was originally described in the yeast as an enzyme of the PPP (pentose phosphate pathway). However, certain organisms and mammalian tissues lack TAL, and the overall reason for its existence is unclea... Biochemical characterization of the initial steps of the Kennedy pathway in Trypanosoma brucei: the ethanolamine and choline kinases [作者：Gibellini, F; Hunter, WN; Smith, TK,期刊：Biochemical Journal, 页码：135-144 , 文章类型： Article，,卷期：2008年415-1] Ethanolamine and choline are major components of the trypanosome membrane phospholipids, in the form of GPEtn (glycero-phosphoethanolamine) and GPCho (glycerophosphocholine). Ethanolamine is also found as an integral com... G-protein binding features and regulation of the RalGDS family member, RGL2 [作者：Ferro, E; Magrini, D; Guazzi, P; Fischer, TH; Pistolesi, S; Pogni, R; White, GC; Trabalzini, L,期刊：Biochemical Journal, 页码：145-154 , 文章类型： Article，,卷期：2008年415-1] RGL2 [RalGDS (Ral guanine nucleotide dissociation stimulator)-like 2] is a member of the RalGDS family that we have previously isolated and characterized as a potential effector for Ras and the Ras analogue Rap lb. The p... Regulation of Nedd4-2 self-ubiquitination and stability by a PY motif located within its HECT-domain [作者：Bruce, MC; Kanelis, V; Fouladkou, F; Debonneville, A; Staub, O; Rotin, D,期刊：Biochemical Journal, 页码：155-163 , 文章类型： Article，,卷期：2008年415-1] Ubiquitin ligases play a pivotal role in substrate recognition and ubiquitin transfer, yet little is known about the regulation of their catalytic activity. Nedd4 (neural-precursor-cell-expressed, developmentally down-re... Glucose regulation of insulin gene expression in pancreatic beta-cells [作者：Andrali, SS; Sampley, ML; Vanderford, NL; Ozcan, S,期刊：Biochemical Journal, 页码：1-10 , 文章类型： Review，,卷期：2008年415-1] Production and secretion of insulin from the P-cells of the pancreas is very crucial in maintaining normoglycaemia. This is achieved by tight regulation of insulin synthesis and exocytosis from the P-cells in response to... Signalling cascades integrating light-enhanced nitrate metabolism [作者：Lillo, C,期刊：Biochemical Journal, 页码：11-19 , 文章类型： Review，,卷期：2008年415-1] In higher plants, light is crucial for regulation of nitrate uptake, translocation and assimilation into organic compounds. Part of this metabolism is tightly coupled to photosynthesis because the enzymes involved, nitri...