- A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis
[作者：Towler, MC; Fogarty, S; Hawley, SA; Pan, DA; Martin, DMA; Morrice, NA; McCarthy, A; Galardo, MN; Meroni, SB; Cigorraga, SB; Ashworth, A; Sakamoto, K; Hardie, DG,期刊：Biochemical Journal, 页码：1-14 , 文章类型： Article，,卷期：2008年416-1]
- LKB1 was discovered as a tumour suppressor mutated in Peutz-Jeghers syndrome, and is a gene involved in cell polarity as well as an upstream protein kinase for members of the AMP-activated protein kinase family. We repor...
- Disruption of a mitochondrial RNA-binding protein gene results in decreased cytochrome b expression and a marked reduction in ubiquinol-cytochrome c reductase activity in mouse heart mitochondria
[作者：Xu, F; Ackerley, C; Maj, MC; Addis, JBL; Levandovskiy, V; Lee, J; MacKay, N; Cameron, JM; Robinson, BH,期刊：Biochemical Journal, 页码：15-26 , 文章类型： Article，,卷期：2008年416-1]
- Mice homozygous for a defect in the PTCD2 (pentatricopeptide repeat domain protein 2) gene were generated in order to study the role of this protein in mitochondrial RNA metabolism. These mice displayed specific but vari...
- Crystal structures of the starch-binding domain from Rhizopus oryzae glucoamylase reveal a polysaccharide-binding path
[作者：Tung, JY; Chang, MDT; Chou, WI; Liu, YY; Yeh, YH; Chang, FY; Lin, SC; Qiu, ZL; Sun, YJ,期刊：Biochemical Journal, 页码：27-36 , 文章类型： Article，,卷期：2008年416-1]
- GA (glucoamylase) hydrolyses starch and polysaccharides to beta-D-glucose. RoGA (Rhizopus oryzae GA) consists of two functional domains, an N-terminal SBD (starch-binding domain) and a C-terminal catalytic domain, which ...
- Role of Fyn and P13K in H2O2-incluced inhibition of apical Cl-/OH- exchange activity in human intestinal epithelial cells
[作者：Saksena, S; Gill, RK; Tyagi, S; Alrefai, WA; Ramaswamy, K; Dudeja, PK,期刊：Biochemical Journal, 页码：99-108 , 文章类型： Article，,卷期：2008年416-1]
- H2O2 is a highly reactive oxygen metabolite that has been implicated as an important mediator of inflammation-induced intestinal injury associated with ischaemia/reperfusion, radiation and inflammatory bowel disease. Pre...
- Asp(218) participates with Asp(213) to bind a Ca2+ atom into the S1 subsite of aminopeptidase A: a key element for substrate specificity
[作者：Claperon, M; Rozenfeld, R; Iturrioz, X; Inguimbert, N; Okada, M; Roques, B; Maigret, B; Llorens-Cortes, C,期刊：Biochemical Journal, 页码：37-46 , 文章类型： Article，,卷期：2008年416-1]
- APA (aminopeptidase A; EC 3.4.11.7) is a membrane-bound zinc metallopeptidase, also activated by Ca2+, involved in the formation of brain angiotensin 111, which exerts a tonic stimulatory action on the central control of...
- A possible biochemical link between NADPH oxidase (Nox) 1 redox-signalling and ERp72
[作者：Chen, W; Shang, WH; Adachi, Y; Hirose, K; Ferrari, DM; Kamata, T,期刊：Biochemical Journal, 页码：55-63 , 文章类型： Article，,卷期：2008年416-1]
- Emerging evidence indicates that Nox (NADPH oxidase) 1-generated ROS (reactive oxygen species) play critical regulatory roles in various cellular processes, yet little is known of direct targets for the oxidase. In the p...
- An exceptional salt-tolerant antimicrobial peptide derived from a novel gene family of haemocytes of the marine invertebrate Ciona intestinalis
[作者：Fedders, H; Michalek, M; Groetzinger, J; Leippe, M,期刊：Biochemical Journal, 页码：65-75 , 文章类型： Article，,卷期：2008年416-1]
- A novel gene family coding for putative antimicrobial peptides,vas identified in the EST (expressed sequence tag) database,if the sea squirt Ciona intestinalis, and one of these genes was molecularly cloned from the Nort...
- Tyrosine modification enhances metal-ion binding
[作者：Baldwin, GS; Bailey, MF; Shehan, BP; Sims, L; Norton, RS,期刊：Biochemical Journal, 页码：77-84 , 文章类型： Article，,卷期：2008年416-1]
- Tyrosine sulfation is a common modification of many proteins, and the ability to phosphorylate tyrosine residues is an intrinsic property of many growth-factor receptors. In the present study, we have utilized the peptid...
- Architectural factor HMGA induces promoter bending and recruits C/EBP and GATA during silkmoth chorion gene regulation
[作者：Papantonis, A; Broeck, JV; Lecanidou, R,期刊：Biochemical Journal, 页码：85-97 , 文章类型： Article，,卷期：2008年416-1]
A protein displaying significant similarity to mammalian HMGA (high-mobility group A) proteins, but also bearing unique structural features, was isolated from silkmoth (Bombyx mori) follicular cells. This factor, name...
- Identification of lysine residues critical for the transcriptional activity and polyubiquitination of the NF-kappa B family member RelB
[作者：Leidner, U; Palkowitsch, L; Marienfeld, U; Fischer, D; Marienfeld, R,期刊：Biochemical Journal, 页码：117-127 , 文章类型： Article，,卷期：2008年416-1]
- RelB is the key component of the alternative NF-kappa B (nuclear factor kappa B) signalling pathway. However, RelB exerts also a negative effect via the recruitment of a DNMT1 (DNA methyl-transferase 1)-Daxx (death domai...
- Role of the domain encompassing Arg(304)-Ile(328) in rat P2X(2) receptor conformation revealed by alterations in complex glycosylation at Asn(298)
[作者：Young, MT; Zhang, YH; Cao, LS; Broomhead, H; Jiang, LH,期刊：Biochemical Journal, 页码：137-143 , 文章类型： Article，,卷期：2008年416-1]
- The final 25 amino acids of the ectodomain of the P2X receptors, immediately prior to the second TM (transmembrane domain) (pre-TM2: Arg(304)-Ile(328) in rat P2X,), are highly conserved. Whole-cell patch clamp recordings...
- Effects of phosphatidylethanolamine glycation on lipid-protein interactions and membrane protein thermal stability
[作者：Levi, V; Giraldo, AMV; Castello, PR; Rossi, JPFC; Flecha, FLG,期刊：Biochemical Journal, 页码：145-152 , 文章类型： Article，,卷期：2008年416-1]
- Non-enzymatic glycation of biomolecules has been implicated in the pathophysiology of aging and diabetes. Among the potential targets for glycation are biological membranes, characterized by a complex organization of lip...
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