个性化文献订阅>文章检索

文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共16条记录   Protein glycation in vivo: functional and structural effects on yeast enolase [作者：Gomes, RA; Oliveira, LMA; Silva, M; Ascenso, C; Quintas, A; Costa, G; Coelho, AV; Silva, MS; Ferreira, AEN; Freire, AP; Cordeiro, C,期刊：Biochemical Journal, 页码：317-326 , 文章类型： Article，,卷期：2008年416-3] Protein glycation is involved in structure and stability changes that impair protein functionality, which is associated with several human diseases, such as diabetes and amyloidotic neuropathies (Alzheimer's disease, Par... The 5 '-3 ' exoribonuclease Pacman is required for normal male fertility and is dynamically localized in cytoplasmic particles in Drosophila testis cells [作者：Zabolotskaya, MV; Grima, DP; Lin, MD; Chou, TB; Newbury, SF,期刊：Biochemical Journal, 页码：327-335 , 文章类型： Article，,卷期：2008年416-3] The exoribonuclease Xrn 1 is widely recognised as a key component in the 5'-3' RNA degradation pathway. This enzyme is highly conserved between yeast and humans and is known to be involved in RNA interference and degrada... Constitutive expression of cyclo-oxygenase 2 transgene in hepatocytes protects against liver injury [作者：Mayoral, R; Molla, B; Flores, JM; Bosca, L; Casado, M; Martin-Sanz, P,期刊：Biochemical Journal, 页码：337-346 , 文章类型： Article，,卷期：2008年416-3] The effect of COX (cyclo-oxygenase)-2-dependent PGs (prostaglandins) in acute liver injury has been investigated in transgenic mice that express human COX-2 in hepatocytes. We have used three well-established models of l... Mfsd2a encodes a novel major facilitator superfamily domain-containing protein highly induced in brown adipose tissue during fasting and adaptive thermogenesis [作者：Angers, M; Uldry, M; Kong, D; Gimble, JM; Jetten, AM,期刊：Biochemical Journal, 页码：347-355 , 文章类型： Article，,卷期：2008年416-3] This study describes the identification of Mfsd2a (major facilitator superfamily domain-containing protein 2a), a novel mammalian major facilitator superfamily domain-containing protein, and ail additional closely relate... C-terminal residues of mature human T-lymphotropic virus type 1 protease are critical for dimerization and catalytic activity [作者：Kadas, J; Boross, P; Weber, IT; Bagossi, P; Matuz, K; Tozser, J,期刊：Biochemical Journal, 页码：357-364 , 文章类型： Article，,卷期：2008年416-3] HTLV-1 [HTLV (human T-cell lymphotrophic virus) type 1] is associated with a number of human diseases. HTLV-1 protease is essential for virus replication, and similarly to HIV-1 protease, it is a potential target for che... The splicing factor Prp17 interacts with the U2, U5 and U6 snRNPs and associates with the spliceosome pre- and post-catalysis [作者：Sapra, AK; Khandelia, P; Vijayraghavan, U,期刊：Biochemical Journal, 页码：365-374 , 文章类型： Article，,卷期：2008年416-3] Saccharomyces cerevisiae PRP17-null mutants are temperature for growth. In vitro splicing with extracts lacking Prp17 are kinetically slow for the first step of splicing and are arrested for the second step at temperatur... Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1 alpha [作者：Pollard, PJ; Loenarz, C; Mole, DR; McDonough, MA; Gleadle, JM; Schofield, CJ; Ratcliffe, PJ,期刊：Biochemical Journal, 页码：387-394 , 文章类型： Article，,卷期：2008年416-3] The transcription factor HIF (hypoxia-inducible factor) mediates a highly pleiotrophic response to hypoxia. Many recent Studies have focused on defining the extent of this transcriptional response. In the present study w... Protective effect of paraoxonase-2 against endoplasmic reticulum stress-induced apoptosis is lost upon disturbance of calcium homoeostasis [作者：Horke, S; Witte, I; Wilgenbus, P; Altenhofer, S; Kruger, M; Li, HG; Forstermann, U,期刊：Biochemical Journal, 页码：395-405 , 文章类型： Article，,卷期：2008年416-3] PON2 (paraoxonase-2) is a ubiquitously expressed antioxidative protein which is largely found in the ER (endoplasmic reticulum). Addressing the cytoprotective functions of PON2, we observed that PON2 overexpression provi... PGC-1 alpha induces dynamic protein interactions on the ERR alpha gene multi-hormone response element nucleosome in kidney cells [作者：Wang, LL; Li, Y; Hu, P; Teng, CT,期刊：Biochemical Journal, 页码：407-419 , 文章类型： Article，,卷期：2008年416-3] ERR (oestrogen-related receptor)-alpha modulates the oestrogen signalling pathway and regulates genes participating in the physiological energy balance programme. Oestrogen and PGC-1 alpha (peroxisome proliferator-activa... Regulation of microtubule nucleation from membranes by complexes of membrane-bound gamma-tubulin with Fyn kinase and phosphoinositide 3-kinase [作者：Macurek, L; Draberova, E; Richterova, V; Sulimenko, V; Sulimenko, T; Draberova, L; Markova, V; Draber, P,期刊：Biochemical Journal, 页码：421-430 , 文章类型： Article，,卷期：2008年416-3] The molecular mechanisms controlling microtubule formation in cells with non-centrosomal microtubular arrays are not yet fully understood. The key component of microtubule nucleation is gamma-tubulin. Although previous r... Phenolic substrates and suicide inactivation of tyrosinase: kinetics and mechanism [作者：Munoz-Munoz, JL; Garcia-Molina, F; Garcia-Ruiz, PA; Molina-Alarcon, M; Tudela, J; Garcia-Canovas, F; Rodriguez-Lopez, JN,期刊：Biochemical Journal, 页码：431-440 , 文章类型： Article，,卷期：2008年416-3] The suicide inactivation mechanism of tyrosinase acting on its substrates has been studied. The kinetic analysis of the proposed mechanism during the transition phase provides explicit analytical expressions for the conc... mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1) [作者：Garcia-Martinez, JM; Alessi, DR,期刊：Biochemical Journal, 页码：375-385 , 文章类型： Article，,卷期：2008年416-3] SGK1 (serum- and glucocorticoid-induced protein kinase 1) is a member of the AGC (protein kinase A/protein kinase G/protein kinase C) family of protein kinases and is activated by agonists including growth factors. SGK1 ... Tryptophan residues are targets in hypothiocyanous acid-mediated protein oxidation [作者：Hawkins, CL; Pattison, DI; Stanley, NR; Davies, MJ,期刊：Biochemical Journal, 页码：441-452 , 文章类型： Article，,卷期：2008年416-3] Myeloperoxidase, released by activated phagocytes, forms reactive oxidants by catalysing the reaction of halide and pseudohalide ions with H2O2. These oxidants have been linked to tissue damage in a range of inflammatory... Transcriptional regulation of the TGF-beta 1 promoter by androgen receptor [作者：Qi, W; Gao, S; Wang, ZX,期刊：Biochemical Journal, 页码：453-462 , 文章类型： Article，,卷期：2008年416-3] TGF (transforming growth factor)-beta 1 is a multifunctional cytokine that influences homoeostatic processes of various tissues. TGF-beta 1 expression is inhibited by androgens in the prostate gland, whereas its expressi... SMILE, a new orphan nuclear receptor SHP-interacting protein, regulates SHP-repressed estrogen receptor transactivation [作者：Xie, YB; Lee, OH; Nedumaran, B; Seong, HA; Lee, KM; Ha, H; Lee, IK; Yun, Y; Choi, HS,期刊：Biochemical Journal, 页码：463-473 , 文章类型： Article，,卷期：2008年416-3] SHP (small heterodimer partner) is a well-known NR (nuclear-receptor) co-regulator. In the present study, we have identified a new SHP-interacting protein, termed SMILE (SHP-interacting leucine zipper protein), which was... Role of histidine residues in EcoP15I DNA methyltransferase activity as probed by chemical modification and site-directed mutagenesis (vol 410, pg 543, 2008) [作者：Jois, PS; Madhu, N; Rao, DN,期刊：Biochemical Journal, 页码：475-475 , 文章类型： Correction，,卷期：2008年416-3]