- Cell Signaling by Receptor Tyrosine Kinases
[作者：Lemmon, MA; Schlessinger, J,期刊：Cell, 页码：1117-1134 , 文章类型： Article，,卷期：2010年141-7]
- Recent structural studies of receptor tyrosine kinases (RTKs) have revealed unexpected diversity in the mechanisms of their activation by growth factor ligands. Strategies for inducing dimerization by ligand binding are ...
- Virus-Plus-Susceptibility Gene Interaction Determines Crohn's Disease Gene Atg16L1 Phenotypes in Intestine
[作者：Cadwell, K; Patel, KK; Maloney, NS; Liu, TC; Ng, ACY; Storer, CE; Head, RD; Xavier, R; Stappenbeck, TS; Virgin, HW,期刊：Cell, 页码：1135-U64 , 文章类型： Article，,卷期：2010年141-7]
- It is unclear why disease occurs in only a small proportion of persons carrying common risk alleles of disease susceptibility genes. Here we demonstrate that an interaction between a specific virus infection and a mutati...
- Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations
[作者：Lee, JH; Yu, WH; Kumar, A; Lee, S; Mohan, PS; Peterhoff, CM; Wolfe, DM; Martinez-Vicente, M; Massey, AC; Sovak, G; Uchiyama, Y; Westaway, D; Cuervo, AM; Nixon, RA,期刊：Cell, 页码：1146-U91 , 文章类型： Article，,卷期：2010年141-7]
- Macroautophagy is a lysosomal degradative pathway essential for neuron survival. Here, we show that macroautophagy requires the Alzheimer's disease (AD)-related protein presenilin-1 (PS1). In PS1 null blastocysts, neuron...
- LINE-1 Retrotransposition Activity in Human Genomes
[作者：Beck, CR; Collier, P; Macfarlane, C; Malig, M; Kidd, JM; Eichler, EE; Badge, RM; Moran, JV,期刊：Cell, 页码：1159-U110 , 文章类型： Article，,卷期：2010年141-7]
- Highly active (i.e., "hot") long interspersed element-1 (LINE-1 or L1) sequences comprise the bulk of retrotransposition activity in the human genome; however, the abundance of hot L1s in the human population remains lar...
- Mobile Interspersed Repeats Are Major Structural Variants in the Human Genome
[作者：Huang, CRL; Schneider, AM; Lu, YQ; Niranjan, T; Shen, PL; Robinson, MA; Steranka, JP; Valle, D; Civin, CI; Wang, T; Wheelan, SJ; Ji, HK; Boeke, JD; Burns, KH,期刊：Cell, 页码：1171-U129 , 文章类型： Article，,卷期：2010年141-7]
- Characterizing structural variants in the human genome is of great importance, but a genome wide analysis to detect interspersed repeats has not been done. Thus, the degree to which mobile DNAs contribute to genetic dive...
- Pro Isomerization in MLL1 PHD3-Bromo Cassette Connects H3K4me Readout to CyP33 and HDAC-Mediated Repression
[作者：Wang, ZX; Song, JK; Milne, TA; Wang, GG; Li, HT; Allis, CD; Patel, DJ,期刊：Cell, 页码：1183-U151 , 文章类型： Article，,卷期：2010年141-7]
- The MLL1 gene is a frequent target for recurrent chromosomal translocations, resulting in transformation of hematopoietic precursors into leukemia stem cells. Here, we report on structure-function studies that elucidate ...
- A MicroRNA Targeting Dicer for Metastasis Control
[作者：Martello, G; Rosato, A; Ferrari, F; Manfrin, A; Cordenonsi, M; Dupont, S; Enzo, E; Guzzardo, V; Rondina, M; Spruce, T; Parenti, AR; Daidone, MG; Bicciato, S; Piccolo, S,期刊：Cell, 页码：1195-U176 , 文章类型： Article，,卷期：2010年141-7]
- Although specific microRNAs (miRNAs) can be upregulated in cancer, global miRNA downregulation is a common trait of human malignancies. The mechanisms of this phenomenon and the advantages it affords remain poorly unders...
|