- Targeting the Hsp90 Molecular Chaperone with Novel Macrolactams. Synthesis, Structural, Binding, and Cellular Studies
[作者:DAY JAMES E H; SHARP SWEE Y; ROWLANDS MARTIN G; AHERNE WYNNE; HAYES ANGELA; RAYNAUD FLORENCE I; LEWIS WILLIAM; ROE S MARK; PRODROMOU CHRISOSTOMOS; PEARL LAURENCE H; WORKMAN PAUL; MOODY CHRISTOPHER J,期刊:ACS CHEMICAL BIOLOGY, 页码:1339-1347 , 文章类型: Article,,卷期:2011年6-12]
- A series of resorcylic acid macrolactams, nitrogen analogues of the naturally occurring macrolactone radicicol, have been prepared by chemical synthesis and evaluated as inhibitors of heat shock protein 90 (Hsp90), an em...
- Parsimonious Discovery of Synergistic Drug Combinations
[作者:SEVERYN BRYAN; LIEHR ROBERT A; WOLICKI ALEX; NGUYEN KEVIN H; HUDAK EDWARD M; FERRER MARC; CALDWELL JEREMY S; HERMES JEFFREY D; LI JING; TUDOR MATTHEW,期刊:ACS CHEMICAL BIOLOGY, 页码:1391-1398 , 文章类型: Article,,卷期:2011年6-12]
- Combination therapies that enhance efficacy or permit reduced dosages to be administered have seen great success in a variety of therapeutic applications. More fundamentally, the discovery of epistatic pathway interactio...
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