- Cellular pathophysiology of ischemic acute kidney injury
[作者:Bonventre, JV; Yang, L,期刊:Journal of clinical investigation, 页码:4210-4221 , 文章类型: Article,,卷期:2011年121-11]
- Ischemic kidney injury often occurs in the context of multiple organ failure and sepsis. Here, we review the major components of this dynamic process, which involves hemodynamic alterations, inflammation, and endothelial...
- Ceramides as modulators of cellular and whole-body metabolism
[作者:Bikman, BT; Summers, SA,期刊:Journal of clinical investigation, 页码:4222-4230 , 文章类型: Article,,卷期:2011年121-11]
- Nearly all stress stimuli (e.g., inflammatory cytokines, glucocorticoids, chemotherapeutics, etc.) induce sphingolipid synthesis, leading to the accumulation of ceram ides and ceramide metabolites. While the role of thes...
- Th2 signals induce epithelial injury in mice and are compatible with the biliary atresia phenotype
[作者:Li, J; Bessho, K; Shivakumar, P; Mourya, R; Mohanty, SK; dos Santos, JL; Miura, IK; Porta, G; Bezerra, JA,期刊:Journal of clinical investigation, 页码:4244-4256 , 文章类型: Article,,卷期:2011年121-11]
- Biliary atresia (BA) is a destructive cholangiopathy of childhood in which Th1 immunity has been mechanistically linked to the bile duct inflammation and obstruction that culminate in liver injury. Based on reports of de...
- SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia
[作者:Pearson, HB; Perez-Mancera, PA; Dow, LE; Ryan, A; Tennstedt, P; Bogani, D; Elsum, I; Greenfield, A; Tuveson, DA; Simon, R; Humbert, PO,期刊:Journal of clinical investigation, 页码:4257-4267 , 文章类型: Article,,卷期:2011年121-11]
- Loss of cellular polarity is a hallmark of epithelial cancers, raising the possibility that regulators of polarity have a role in suppressing tumorigenesis. The Scribble complex is one of at least three interacting prote...
- Regulatory B cell production of IL-10 inhibits lymphoma depletion during CD20 immunotherapy in mice
[作者:Horikawa, M; Minard-Colin, V; Matsushita, T; Tedder, TF,期刊:Journal of clinical investigation, 页码:4268-4280 , 文章类型: Article,,卷期:2011年121-11]
- Current therapies for non-Hodgkin lymphoma commonly include CD20 mAb to deplete tumor cells. However, the response is not durable in a substantial proportion of patients. Herein, we report our studies in mice testing the...
- Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction
[作者:Schenk, S; McCurdy, CE; Philp, A; Chen, MZ; Holliday, MJ; Bandyopadhyay, GK; Osborn, O; Baar, K; Olefsky, JM,期刊:Journal of clinical investigation, 页码:4281-4288 , 文章类型: Article,,卷期:2011年121-11]
- Skeletal muscle insulin resistance is a key component of the etiology of type 2 diabetes. Caloric restriction (CR) enhances the sensitivity of skeletal muscle to insulin. However, the molecular signals within skeletal mu...
- Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients
[作者:Malhotra, D; Thimmulappa, RK; Mercado, N; Ito, K; Kombairaju, P; Kumar, S; Ma, JF; Feller-Kopman, D; Wise, R; Barnes, P; Biswal, S,期刊:Journal of clinical investigation, 页码:4289-4302 , 文章类型: Article,,卷期:2011年121-11]
- Chronic obstructive pulmonary disease (COPD), which is caused primarily by cigarette smoking, is a major health problem worldwide. The progressive decline in lung function that occurs in COPD is a result of persistent in...
- Differential IL-21 signaling in APCs leads to disparate Th17 differentiation in diabetes-susceptible NOD and diabetes-resistant NOD.Idd3 mice
[作者:Liu, SM; Lee, DH; Sullivan, JM; Chung, D; Jager, A; Shum, BOV; Sarvetnick, NE; Anderson, AC; Kuchroo, VK,期刊:Journal of clinical investigation, 页码:4303-4310 , 文章类型: Article,,卷期:2011年121-11]
- Type 1 diabetes (T1D) is an autoimmune disease that shows familial aggregation in humans and likely has genetic determinants. Disease linkage studies have revealed many susceptibility loci for T1D in mice and humans. The...
- Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers
[作者:Ebi, H; Corcoran, RB; Singh, A; Chen, Z; Song, Y; Lifshits, E; Ryan, DP; Meyerhardt, JA; Benes, C; Settleman, J; Wong, KK; Cantley, LC; Engelman, JA,期刊:Journal of clinical investigation, 页码:4311-4321 , 文章类型: Article,,卷期:2011年121-11]
- Therapies inhibiting receptor tyrosine kinases (RTKs) are effective against some human cancers when they lead to simultaneous downregulation of PI3K/AKT and MEK/ERK signaling. However, mutant KRAS has the capacity to dir...
- A high-throughput single-cell analysis of human CD8(+) T cell functions reveals discordance for cytokine secretion and cytolysis
[作者:Varadarajan, N; Julg, B; Yamanaka, YJ; Chen, HB; Ogunniyi, AO; McAndrew, E; Porter, LC; Piechocka-Trocha, A; Hill, BJ; Douek, DC; Pereyra, F; Walker, BD; Love, JC,期刊:Journal of clinical investigation, 页码:4322-4331 , 文章类型: Article,,卷期:2011年121-11]
- CD8(+) T cells are a key component of the adaptive immune response to viral infection. An inadequate CD8(+) T cell response is thought to be partly responsible for the persistent chronic infection that arises following i...
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