- Valosin-containing protein and neurofibromin interact to regulate dendritic spine density
[作者：Wang, HF; Shih, YT; Chen, CY; Chao, HW; Lee, MJ; Hsueh, YP,期刊：Journal of clinical investigation, 页码：4820-4837 , 文章类型： Article，,卷期：2011年121-12]
- Inclusion body myopathy with Paget disease of bone and frontotemporal dementia (IBMPFD) is an autosomal dominant disorder characterized by progressive myopathy that is often accompanied by bone weakening and/or frontotem...
- Loss of nuclear pro-IL-16 facilitates cell cycle progression in human cutaneous T cell lymphoma
[作者：Curiel-Lewandrowski, C; Yamasaki, H; Si, CP; Jin, XY; Zhang, YJ; Richmond, J; Tuzova, M; Wilson, K; Sullivan, B; Jones, D; Ryzhenko, N; Little, F; Kupper, TS; Center, DM; Cruikshank, WW,期刊：Journal of clinical investigation, 页码：4838-4849 , 文章类型： Article，,卷期：2011年121-12]
- Cutaneous T cell lymphomas (CTCLs) represent a heterogeneous group of non-Hodgkin lymphomas that affect the skin. The pathogenesis of these conditions is poorly understood. For example, the signaling mechanisms contribut...
- Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration
[作者：Malato, Y; Naqvi, S; Schurmann, N; Ng, R; Wang, B; Zape, J; Kay, MA; Grimm, D; Willenbring, H,期刊：Journal of clinical investigation, 页码：4850-4860 , 文章类型： Article，,卷期：2011年121-12]
- Recent evidence has contradicted the prevailing view that homeostasis and regeneration of the adult liver are mediated by self duplication of lineage-restricted hepatocytes and biliary epithelial cells. These new data su...
- In vivo visualization and attenuation of oxidized lipid accumulation in hypercholesterolemic zebrafish
[作者：Fang, LH; Green, SR; Baek, JS; Lee, SH; Ellett, F; Deer, E; Lieschke, GJ; Witztum, JL; Tsimikas, S; Miller, YI,期刊：Journal of clinical investigation, 页码：4861-4869 , 文章类型： Article，,卷期：2011年121-12]
- Oxidative modification of LDL is an early pathological event in the development of atherosclerosis. Oxidation events such as malondialdehyde (MDA) formation may produce specific, immunogenic epitopes. Indeed, antibodies ...
- Connexins protect mouse pancreatic beta cells against apoptosis
[作者：Klee, P; Allagnat, F; Pontes, H; Cederroth, M; Charollais, A; Caille, D; Britan, A; Haefliger, JA; Meda, P,期刊：Journal of clinical investigation, 页码：4870-4879 , 文章类型： Article，,卷期：2011年121-12]
- Type 1 diabetes develops when most insulin-producing beta cells of the pancreas are killed by an autoimmune attack. The in vivo conditions modulating the sensitivity and resistance of beta cells to this attack remain lar...
- Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload
[作者：Preza, GC; Ruchala, P; Pinon, R; Ramos, E; Qiao, B; Peralta, MA; Sharma, S; Waring, A; Ganz, T; Nemeth, E,期刊：Journal of clinical investigation, 页码：4880-4888 , 文章类型： Article，,卷期：2011年121-12]
- Iron overload is the hallmark of hereditary hemochromatosis and a complication of iron-loading anemias such as beta-thalassemia. Treatment can be burdensome and have significant side effects, and new therapeutic options ...
- Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency
[作者：Sancho-Shimizu, V; de Diego, RP; Lorenzo, L; Halwani, R; Alangari, A; Israelsson, E; Fabrega, S; Cardon, A; Maluenda, J; Tatematsu, M; Mahvelati, F; Herman, M; Ciancanelli, M; Guo, YQ; AlSum, Z; Alkhamis, N; Al-Makadma, AS; Ghadiri, A; Boucherit, S; Plancoulaine, S; Picard, C; Rozenberg, F; Tardieu, M; Lebon, P; Jouanguy, E; Rezaei, N; Seya, T; Matsumoto, M; Chaussabel, D; Puel, A; Zhang, SY; Abel, L; Al-Muhsen, S; Casanova, JL,期刊：Journal of clinical investigation, 页码：4889-4902 , 文章类型： Article，,卷期：2011年121-12]
- Herpes simplex encephalitis (HSE) is the most common sporadic viral encephalitis of childhood. Autosomal recessive (AR) UNC-93B and TLR3 deficiencies and autosomal dominant (AD) TLR3 and TRAF3 deficiencies underlie HSE i...
- Hematopoietic AMPK beta 1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity
[作者：Galic, S; Fullerton, MD; Schertzer, JD; Sikkema, S; Marcinko, K; Walkley, CR; Izon, D; Honeyman, J; Chen, ZP; van Denderen, BJ; Kemp, BE; Steinberg, GR,期刊：Journal of clinical investigation, 页码：4903-4915 , 文章类型： Article，,卷期：2011年121-12]
- Individuals who are obese are frequently insulin resistant, putting them at increased risk of developing type 2 diabetes and its associated adverse health conditions. The accumulation in adipose tissue of macrophages in ...
- Activation of K(ATP) channels suppresses glucose production in humans
[作者：Kishore, P; Boucai, L; Zhang, KH; Li, WJ; Koppaka, S; Kehlenbrink, S; Schiwek, A; Esterson, YB; Mehta, D; Bursheh, S; Su, Y; Gutierrez-Juarez, R; Muzumdar, R; Schwartz, GJ; Hawkins, M,期刊：Journal of clinical investigation, 页码：4916-4920 , 文章类型： Article，,卷期：2011年121-12]
- Increased endogenous glucose production (EGP) is a hallmark of type 2 diabetes mellitus. While there is evidence for central regulation of EGP by activation of hypothalamic ATP-sensitive potassium (K(ATP)) channels in ro...
- Age-related increases in PGD(2) expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in mice
[作者：Zhao, JC; Zhao, JX; Legge, K; Perlman, S,期刊：Journal of clinical investigation, 页码：4921-4930 , 文章类型： Article，,卷期：2011年121-12]
- The morbidity and mortality associated with respiratory virus infection is felt most keenly among the elderly. T cells are necessary for viral clearance, and many age-dependent intrinsic T cell defects have been document...
- Pancreatic ductal cells in development, regeneration, and neoplasia
[作者：Reichert, M; Rustgi, AK,期刊：Journal of clinical investigation, 页码：4572-4578 , 文章类型： Article，,卷期：2011年121-12]
- The pancreas is a complex organ comprised of three critical cell lineages: islet (endocrine), acinar, and ductal. This review will focus upon recent insights and advances in the biology of pancreatic ductal cells. In par...
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