- The zinc-binding motif of human RECQ5 beta suppresses the intrinsic strand-annealing activity of its DExH helicase domain and is essential for the helicase activity of the enzyme
[作者:Ren, H; Dou, SX; Zhang, XD; Wang, PY; Kanagaraj, R; Liu, JI; Janscak, P; Hu, JS; Xi, XG,期刊:Biochemical Journal, 页码:425-433 , 文章类型: Article,,卷期:2008年412-3]
- RecQ family helicases, functioning as caretakers of genomic integrity, contain a zinc-binding motif which is highly conserved among these helicases, but does not have a substantial structural similarity with any other kn...
- A cyclic peptidylic inhibitor of murine urokinase-type plasminogen activator: changing species specificity by substitution of a single residue
[作者:Andersen, LM; Wind, T; Hansen, HD; Andreasen, PA,期刊:Biochemical Journal, 页码:447-457 , 文章类型: Article,,卷期:2008年412-3]
- uPA (urokinase-type plasminogen activator) is a potential therapeutic target in a variety of pathological conditions, including cancer. In order to find new principles for inhibiting uPA in murine cancer models, we scree...
- Calmodulin binding to cellular FLICE-like inhibitory protein modulates Fas-induced signalling
[作者:Pawar, PS; Micoli, KJ; Ding, H; Cook, WJ; Kappes, JC; Chen, Y; McDonald, JM,期刊:Biochemical Journal, 页码:459-468 , 文章类型: Article,,卷期:2008年412-3]
- We and others have demonstrated that Fas-mediated apoptosis is a potential therapeutic target for cholangiocarcinoma. Previously, we reported that CaM (calmodulin) antagonists induced apoptosis in cholangiocarcinoma cell...
- Differential effects of N-glycans on surface expression suggest structural differences between the acid-sensing ion channel (ASIC) 1a and ASIC1b
[作者:Kadurin, I; Golubovic, A; Leisle, L; Schindelin, H; Grunder, S,期刊:Biochemical Journal, 页码:469-475 , 文章类型: Article,,卷期:2008年412-3]
- ASICs (acid-sensing ion channels) are H+-gated Na+ channels with a widespread expression pattern in the central and the peripheral nervous system. ASICs have a simple topology with two transmembrane domains, cytoplasmic ...
- AcpA, a member of the GPR1/FUN34/YaaH membrane protein family, is essential for acetate permease activity in the hyphal fungus Aspergillus nidulans
[作者:Robellet, X; Flippi, M; Pegot, S; MacCabe, AP; Velot, C,期刊:Biochemical Journal, 页码:485-493 , 文章类型: Article,,卷期:2008年412-3]
- In a previous study, alcS, a gene of the Aspergillus nidulans alc cluster, was shown to encode a protein that belongs to the GPR1/FUN34/YaaH membrane protein family. BLAST screening of the A. nidulans genome data identif...
- Trafficking properties and activity regulation of the neuronal glycine transporter GLYT2 by protein kinase C
[作者:Fornes, A; Nunez, E; Alonso-Torres, P; Aragon, C; Lopez-Corcuera, B,期刊:Biochemical Journal, 页码:495-506 , 文章类型: Article,,卷期:2008年412-3]
- The neuronal glycine transporter GLYT2 controls the availability of the neurotransmitter in glycinergic synapses, and the modulation of its function may influence synaptic transmission. The active transporter is located ...
- Regulation of Ca2+/calmodulin kinase II by a small C-terminal domain phosphatase
[作者:Gangopadhyay, SS; Gallant, C; Sundberg, EJ; Lane, WS; Morgant, KG,期刊:Biochemical Journal, 页码:507-516 , 文章类型: Article,,卷期:2008年412-3]
- We present here the identification and characterization of an SCP3 (small C-terminal domain phosphatase-3) homologue in smooth muscle and show, for the first time, that it dephosphorylates CaMKII [Ca2+/CaM (calmodulin)-d...
- New members of the glutathione transferase family discovered in red and brown algae
[作者:Herve, C; de Franco, PO; Groisillier, A; Tonon, T; Boyen, C,期刊:Biochemical Journal, 页码:535-544 , 文章类型: Article,,卷期:2008年412-3]
- The GSTs (glutathione transferases) are involved in the detoxification of a wide variety of hydrophobic substrates. These enzymes have been found in virtually all types of organisms, including plants, animals, nematodes ...
- Characterization of an ideal amphipathic peptide as a procoagulant agent
[作者:Ganopolsky, JG; Charbonneau, S; Peng, HT; Shek, PN; Blostein, MD,期刊:Biochemical Journal, 页码:545-551 , 文章类型: Article,,卷期:2008年412-3]
- On the basis of previous evidence that amphipathic helical peptides accelerate Factor IXa activation of Factor X [Blostein, Rigby, Furie, Furie and Gilbert (2000) Biochemistry 39, 12000120061, the present study was desig...
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