- Bromoenol Lactone Inhibits Voltage-Gated Ca(2+) and Transient Receptor Potential Canonical Channels
[作者:Chakraborty, S; Berwick, ZC; Bartlett, PJ; Kumar, S; Thomas, AP; Sturek, M; Tune, JD; Obukhov, AG,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:329-340 , 文章类型: Article,,卷期:2011年339-2]
- Circulating hormones stimulate the phospholipase C beta (PLC)/Ca(2+) influx pathway to regulate numerous cell functions, including vascular tone. It was proposed previously that Ca(2+)-independent phospholipase A(2) (iPL...
- Effects of Chlorpyrifos and Chlorpyrifos-Oxon on the Dynamics and Movement of Mitochondria in Rat Cortical Neurons
[作者:Middlemore-Risher, ML; Adam, BL; Lambert, NA; Terry, AV,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:341-349 , 文章类型: Article,,卷期:2011年339-2]
- Organophosphate (OP)-based pesticides have been used extensively for decades, and as a result, they have become almost ubiquitous in our environment. There is clinical and animal evidence to suggest that chronic exposure...
- Amelioration of Doxorubicin-Induced Cardiotoxicity by an Anticancer-Antioxidant Dual-Function Compound, HO-3867
[作者:Dayton, A; Selvendiran, K; Meduru, S; Khan, M; Kuppusamy, ML; Naidu, S; Kalai, T; Hideg, K; Kuppusamy, P,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:350-357 , 文章类型: Article,,卷期:2011年339-2]
- Doxorubicin (DOX) is a drug commonly used for the treatment of cancer. The development of resistance to DOX is common, and high cumulative doses cause potentially lethal cardiac side effects. HO-3867 (3,5-bis(4-fluoroben...
- CTEP: A Novel, Potent, Long-Acting, and Orally Bioavailable Metabotropic Glutamate Receptor 5 Inhibitor
[作者:Lindemann, L; Jaeschke, G; Michalon, A; Vieira, E; Honer, M; Spooren, W; Porter, R; Hartung, T; Kolczewski, S; Buttelmann, B; Flament, C; Diener, C; Fischer, C; Gatti, S; Prinssen, EP; Parrott, N; Hoffmann, G; Wettstein, JG,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:474-486 , 文章类型: Article,,卷期:2011年339-2]
- The metabotropic glutamate receptor 5 (mGlu5) is a glutamate-activated class C G protein-coupled receptor widely expressed in the central nervous system and clinically investigated as a drug target for a range of indicat...
- Differential Roles of Unsaturated and Saturated Fatty Acids on Autophagy and Apoptosis in Hepatocytes
[作者:Mei, S; Ni, HM; Manley, S; Bockus, A; Kassel, KM; Luyendyk, JP; Copple, BL; Ding, WX,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:487-498 , 文章类型: Article,,卷期:2011年339-2]
- Fatty acid-induced lipotoxicity plays a critical role in the pathogenesis of nonalcoholic liver disease. Saturated fatty acids and unsaturated fatty acids have differential effects on cell death and steatosis, but the me...
- Characterization of Neuroprotective Effects of Biphalin, an Opioid Receptor Agonist, in a Model of Focal Brain Ischemia
[作者:Yang, L; Shah, K; Wang, HZ; Karamyan, VT; Abbruscato, TJ,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:499-508 , 文章类型: Article,,卷期:2011年339-2]
- Approximately 795,000 people experience a new or recurrent stroke in the United States annually. The purpose of this study was to assess the protective effect of a nonselective opioid receptor agonist, biphalin, in brain...
- Exposure Levels of Anti-LINGO-1 Li81 Antibody in the Central Nervous System and Dose-Efficacy Relationships in Rat Spinal Cord Remyelination Models after Systemic Administration
[作者:Pepinsky, RB; Shao, ZH; Ji, BX; Wang, Q; Meng, G; Walus, L; Lee, XH; Hu, YH; Graff, C; Garber, E; Meier, W; Mi, S,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:519-529 , 文章类型: Article,,卷期:2011年339-2]
- LINGO-1 (leucine-rich repeat and Ig domain containing NOGO receptor interacting protein-1) is a negative regulator of myelination and repair of damaged axons in the central nervous system (CNS). Blocking LINGO-1 function...
- 4-Methylmethcathinone (Mephedrone): Neuropharmacological Effects of a Designer Stimulant of Abuse
[作者:Hadlock, GC; Webb, KM; McFadden, LM; Chu, PW; Ellis, JD; Allen, SC; Andrenyak, DM; Vieira-Brock, PL; German, CL; Conrad, KM; Hoonakker, AJ; Gibb, JW; Wilkins, DG; Hanson, GR; Fleckenstein, AE,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:530-536 , 文章类型: Article,,卷期:2011年339-2]
- The designer stimulant 4-methylmethcathinone (mephedrone) is among the most popular of the derivatives of the naturally occurring psychostimulant cathinone. Mephedrone has been readily available for legal purchase both o...
- Pharmacological Characterization of 2-Methyl-N-((2 '-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl)methyl)propan-1-amine (PF-04455242), a High-Affinity Antagonist Selective for kappa-Opioid Receptors
[作者:Grimwood, S; Lu, Y; Schmidt, AW; Vanase-Frawley, MA; Sawant-Basak, A; Miller, E; McLean, S; Freeman, J; Wong, S; McLaughlin, JP; Verhoest, PR,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:555-566 , 文章类型: Article,,卷期:2011年339-2]
- 2-Methyl-N-((2'-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl)methyl)propan-1-amine (PF-04455242) is a novel kappa-opioid receptor (KOR) antagonist with high affinity for human (3 nM), rat (21 nM), and mouse (22 nM) KOR, a simi...
- Preclinical Pharmacology and Pharmacokinetics of AZD3783, a Selective 5-Hydroxytryptamine 1B Receptor Antagonist
[作者:Zhang, ML; Zhou, DAS; Wang, Y; Maier, DL; Widzowski, DV; Sobotka-Briner, CD; Brockel, BJ; Potts, WM; Shenvi, AB; Bernstein, PR; Pierson, ME,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:567-578 , 文章类型: Article,,卷期:2011年339-2]
- The preclinical pharmacology and pharmacokinetic properties of (2R)-6-methoxy-8-(4-methylpiperazin-1-yl)-N-(4-morpholin-4-ylphenyl)chromane-2-carboxamide (AZD3783), a potent 5-hydroxytryptamine 1B (5-HT(1B)) receptor ant...
- Beneficial Effects of Combination of Valsartan and Amlodipine on Salt-Induced Brain Injury in Hypertensive Rats
[作者:Dong, YF; Kataoka, K; Tokutomi, Y; Nako, H; Nakamura, T; Toyama, K; Sueta, D; Koibuchi, N; Yamamoto, E; Ogawa, H; Kim-Mitsuyama, S,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:358-366 , 文章类型: Article,,卷期:2011年339-2]
- The optimum antihypertensive treatment for prevention of hypertensive stroke has yet to be elucidated. This study was undertaken to examine the benefit of a combination of valsartan, an angiotensin II type 1 (AT1) recept...
- Role of Neuronal Nitric-Oxide Synthase in Estrogen-Induced Relaxation in Rat Resistance Arteries
[作者:Lekontseva, O; Chakrabarti, S; Jiang, YY; Cheung, CC; Davidge, ST,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:367-375 , 文章类型: Article,,卷期:2011年339-2]
- Estrogen has antihypertensive and vasorelaxing properties, partly via activation of endothelial nitric-oxide synthase (eNOS). Recently, neuronal nitric-oxide synthase (nNOS) has been detected in vascular cells, although ...
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