- Functional role of inositol-1,4,5-trisphosphate-3-kinase-A for motility of malignant transformed cells
[作者:Windhorst, S; Kalinina, T; Schmid, K; Blechner, C; Kriebitzsch, N; Hinsch, R; Chang, L; Herich, L; Schumacher, U; Mayr, GW,期刊:International Journal of Cancer, 页码:1300-1309 , 文章类型: Article,,卷期:2011年129-6]
- Cell migration is one of the hallmarks of metastatic disease and thus identification of migration promoting proteins is crucial for the understanding of metastasis formation. Here we show that the neuron-specific, F-acti...
- Markers of fibrosis and epithelial to mesenchymal transition demonstrate field cancerization in histologically normal tissue adjacent to breast tumors
[作者:Trujillo, KA; Heaphy, CM; Mai, M; Vargas, KM; Jones, AC; Vo, P; Butler, KS; Joste, NE; Bisoffi, M; Griffith, JK,期刊:International Journal of Cancer, 页码:1310-1321 , 文章类型: Article,,卷期:2011年129-6]
- Previous studies have shown that a field of genetically altered but histologically normal tissue extends 1 cm or more from the margins of human breast tumors. The extent, composition and biological significance of this f...
- Differential aminoacylase expression in neuroblastoma
[作者:Long, PM; Stradecki, HM; Minturn, JE; Wesley, UV; Jaworski, DM,期刊:International Journal of Cancer, 页码:1322-1330 , 文章类型: Article,,卷期:2011年129-6]
- Neuroblastoma, a cancer of the sympathetic nervous system, is the most common extracranial solid tumor in children. MYCN amplification and increased BDNF/TrkB signaling are features of high-risk tumors; yet, only 25% of ...
- WAVE3, an actin remodeling protein, is regulated by the metastasis suppressor microRNA, miR-31, during the invasion-metastasis cascade
[作者:Sossey-Alaoui, K; Downs-Kelly, E; Das, M; Izem, L; Tubbs, R; Plow, EF,期刊:International Journal of Cancer, 页码:1331-1343 , 文章类型: Article,,卷期:2011年129-6]
- WAVE3, an actin cytoskeleton remodeling protein, is highly expressed in advanced stages of breast cancer and influences tumor cell invasion. Loss of miR-31 has been associated with cancer progression and metastasis. Here...
- Circulating perivascular progenitors: a target of PDGFR inhibition
[作者:Mancuso, P; Martin-Padura, I; Calleri, A; Marighetti, P; Quarna, J; Rabascio, C; Braidotti, P; Bertolini, F,期刊:International Journal of Cancer, 页码:1344-1350 , 文章类型: Article,,卷期:2011年129-6]
- Cancer blood vessels consist of two interacting types of cells: inner lining endothelial cells (ECs) and surrounding perivascular cells (pericytes, vascular smooth muscle cells or mural cells). PDGFRbeta(CD140b) + progen...
- Re-expression of CEACAM1 long cytoplasmic domain isoform is associated with invasion and migration of colorectal cancer
[作者:Ieda, J; Yokoyama, S; Tamura, K; Takifuji, K; Hotta, T; Matsuda, K; Oku, Y; Nasu, T; Kiriyama, S; Yamamoto, N; Nakamura, Y; Shively, JE; Yamaue, H,期刊:International Journal of Cancer, 页码:1351-1361 , 文章类型: Article,,卷期:2011年129-6]
- Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is known to be downregulated at the transcriptional level in adenoma and carcinoma. Recent reports have shown that CEACAM1 is overexpressed at protein l...
- Elevated frequencies of CD4(+)CD25(+)CD127(lo) regulatory T cells is associated to poor prognosis in patients with acute myeloid leukemia
[作者:Zhang, SH; Han, YX; Wu, JB; Yu, K; Bi, LX; Zhuang, Y; Xu, X,期刊:International Journal of Cancer, 页码:1373-1381 , 文章类型: Article,,卷期:2011年129-6]
- Regulatory T cells (Treg) mediate amelioration of disease and immune homeostasis by inhibiting immune activation and maintaining peripheral immune tolerance. The suppressive mechanisms and clinical significance of Treg h...
- Human leukocyte antigen-G expression is associated with a poor prognosis in patients with esophageal squamous cell carcinoma
[作者:Lin, AF; Zhang, X; Zhou, WJ; Ruan, YY; Xu, DP; Wang, Q; Yan, WH,期刊:International Journal of Cancer, 页码:1382-1390 , 文章类型: Article,,卷期:2011年129-6]
- Human leukocyte antigen (HLA)-G inhibits functions of immune component cells and promotes malignant cells evading from antitumor immunity. We investigated the clinical relevance of HLA-G expression in esophageal squamous...
- Podoplanin expression correlates with sentinel lymph node metastasis in early squamous cell carcinomas of the oral cavity and oropharynx
[作者:Huber, GF; Fritzsche, FR; Zullig, L; Storz, M; Graf, N; Haerle, SK; Jochum, W; Stoeckli, SJ; Moch, H,期刊:International Journal of Cancer, 页码:1404-1409 , 文章类型: Article,,卷期:2011年129-6]
- In patients with early head and neck squamous cell carcinoma (HNSCC), occult lymph node metastasis is difficult to predict by clinical or pathological parameters. However, such parameters are necessary to select patients...
- Reaction of plasma hepatocyte growth factor levels in non-small cell lung cancer patients treated with EGFR-TKIs
[作者:Tanaka, H; Kimura, T; Kudoh, S; Mitsuoka, S; Watanabe, T; Suzumura, T; Tachibana, K; Noguchi, M; Yano, S; Hirata, K,期刊:International Journal of Cancer, 页码:1410-1416 , 文章类型: Article,,卷期:2011年129-6]
- Hepatocyte growth factor induces resistance to epidermal growth factor receptor tyrosine kinase inhibitors. It has been hypothesized that epidermal growth factor receptor tyrosine kinase inhibitors administration may inf...
- Characterization and outcome of breast needle core biopsy diagnoses of lesions of uncertain malignant potential (B3) in abnormalities detected by mammographic screening
[作者:Rakha, EA; Lee, AHS; Jenkins, JA; Murphy, AE; Hamilton, LJ; Ellis, IO,期刊:International Journal of Cancer, 页码:1417-1424 , 文章类型: Article,,卷期:2011年129-6]
- In the setting of breast cancer screening, 5-9% of needle core biopsies are diagnosed as lesions of uncertain malignant potential (B3). The management of these lesions is potentially problematic as the data on their outc...
- A microdosing approach for characterizing formation and repair of carboplatin-DNA monoadducts and chemoresistance
[作者:Henderson, PT; Li, T; He, ML; Zhang, HY; Malfatti, M; Gandara, D; Grimminger, PP; Danenberg, KD; Beckett, L; White, RWD; Turteltaub, KW; Pan, CX,期刊:International Journal of Cancer, 页码:1425-1434 , 文章类型: Article,,卷期:2011年129-6]
- Formation and repair of platinum (Pt)-induced DNA adducts is a critical step in Pt drug-mediated cytotoxicity. Measurement of Pt-DNA adduct kinetics in tumors may be useful for better understanding chemoresistance and th...
- Age as a key factor influencing metastasizing patterns and disease-specific survival after sentinel lymph node biopsy for cutaneous melanoma
[作者:Kretschmer, L; Starz, H; Thoms, KM; Satzger, I; Volker, B; Jung, K; Mitteldorf, C; Bader, C; Siedlecki, K; Kapp, A; Bertsch, HP; Gutzmer, R,期刊:International Journal of Cancer, 页码:1435-1442 , 文章类型: Article,,卷期:2011年129-6]
- In our study, we investigated the impact of the constitutional factor age on the clinical courses of melanoma patients with sentinel lymph node (SLN) biopsy. Descriptive statistics, Kaplan-Meier estimates, logistic regre...
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