- beta-catenin as a potential key target for tumor suppression
[作者:Fu, YJ; Zheng, SH; An, N; Athanasopoulos, T; Popplewell, L; Liang, AH; Li, K; Hu, CC; Zhu, YJ,期刊:International Journal of Cancer, 页码:1541-1551 , 文章类型: Review,,卷期:2011年129-7]
- beta-catenin is a multifunctional protein identified to be pivotal in embryonic patterning, organogenesis and adult homeostasis. It plays a critical structural role in mediating cadherin junctions and is also an essentia...
- Phosphatidylinositol-3 '-kinase/AKT signaling is essential in synovial sarcoma
[作者:Friedrichs, N; Trautmann, M; Endl, E; Sievers, E; Kindler, D; Wurst, P; Czerwitzki, J; Steiner, S; Renner, M; Penzel, R; Koch, A; Larsson, O; Tanaka, S; Kawai, A; Schirmacher, P; Mechtersheimer, G; Wardelmann, E; Buettner, R; Hartmann, W,期刊:International Journal of Cancer, 页码:1564-1575 , 文章类型: Article,,卷期:2011年129-7]
- Synovial sarcomas account for 5-10% of all malignant soft tissue tumors. They have been shown to express different membranous growth factor receptors, many of them signaling via intracellular kinase cascades. In our stud...
- Runx3 suppresses gastric cancer metastasis through inactivation of MMP9 by upregulation of TIMP-1
[作者:Chen, Y; Wei, XF; Guo, CC; Jin, HF; Han, ZY; Han, Y; Qiao, TD; Wu, KC; Fan, DM,期刊:International Journal of Cancer, 页码:1586-1598 , 文章类型: Article,,卷期:2011年129-7]
- Recent studies have suggested that loss of RUNX3 expression is involved with gastric tumor metastasis. However, the precise mechanism of RUNX3-mediated suppression of tumor metastasis remains elusive. We aimed to clarify...
- Calpain-1 expression is associated with relapse-free survival in breast cancer patients treated with trastuzumab following adjuvant chemotherapy
[作者:Storr, SJ; Woolston, CM; Barros, FFT; Green, AR; Shehata, M; Chan, SY; Ellis, IO; Martin, SG,期刊:International Journal of Cancer, 页码:1773-1780 , 文章类型: Article,,卷期:2011年129-7]
- The calpain family, and their endogenous inhibitor calpastatin, has been implicated in cancer progression, and recent in vitro data have indicated a role in trastuzumab resistance. The aims of our study were to examine e...
- Dermatofibrosarcoma protuberans-derived fibrosarcoma: clinical history, biological profile and sensitivity to imatinib
[作者:Stacchiotti, S; Pedeutour, F; Negri, T; Conca, E; Marrari, A; Palassini, E; Collini, P; Keslair, F; Morosi, C; Gronchi, A; Pilotti, S; Casali, PG,期刊:International Journal of Cancer, 页码:1761-1772 , 文章类型: Article,,卷期:2011年129-7]
- Dermatofibrosarcoma Protuberans (DFSP) carries a translocation resulting in the COL1A1/PDGFB fusion-gene, responsible for platelet derived growth factor beta receptor (PDGFRB) activation. Fibrosarcomatous (FS) transforma...
- Human tumor microRNA signatures derived from large-scale oligonucleotide microarray datasets
[作者:Wang, WZ; Peng, B; Wang, D; Ma, XP; Jiang, DK; Zhao, J; Yu, L,期刊:International Journal of Cancer, 页码:1624-1634 , 文章类型: Article,,卷期:2011年129-7]
- The expression profiles of microRNAs (miRNAs) are associated with the initiation and progression of human tumors. DNA microarrays are widely used to explore the expression patterns of miRNAs. Because of the limited sampl...
- Detection of circulating tumor cells as a prognostic factor in patients undergoing radical surgery for non-small-cell lung carcinoma: comparison of the efficacy of the CellSearch Assay (TM) and the isolation by size of epithelial tumor cell method
[作者:Hofman, V; Ilie, MI; Long, E; Selva, E; Bonnetaud, C; Molina, T; Venissac, N; Mouroux, J; Vielh, P; Hofman, P,期刊:International Journal of Cancer, 页码:1651-1660 , 文章类型: Article,,卷期:2011年129-7]
- Comparison of the efficacy of different enrichment methods for detection of circulating tumor cells (CTCs) before radical surgery is lacking in non-small-cell lung carcinoma (NSCLC) patients. Detection and enumeration of...
- Exposure to professional pest control treatments and the risk of childhood acute lymphoblastic leukemia
[作者:Bailey, HD; Armstrong, BK; de Klerk, NH; Fritschi, L; Attia, J; Scott, RJ; Smibert, E; Milne, E,期刊:International Journal of Cancer, 页码:1678-1688 , 文章类型: Article,,卷期:2011年129-7]
- Previous studies suggest that exposure to pesticides increases the risk of childhood acute lymphoblastic leukemia (ALL). The aim of this analysis was to investigate whether professional pest treatments in or around the h...
- Identification of a secretory protein c19orf10 activated in hepatocellular carcinoma
[作者:Sunagozaka, H; Honda, M; Yamashita, T; Nishino, R; Takatori, H; Arai, K; Yamashita, T; Sakai, Y; Kaneko, S,期刊:International Journal of Cancer, 页码:1576-1585 , 文章类型: Article,,卷期:2011年129-7]
- The identification of genes involved in tumor growth is crucial for the development of inventive anticancer treatments. Here, we have cloned a 17-kDa secretory protein encoded by c19orf10 from hepatocellular carcinoma (H...
- Identification of candidate predisposing copy number variants in familial and early-onset colorectal cancer patients
[作者:Venkatachalam, R; Verwiel, ETP; Kamping, EJ; Hoenselaar, E; Gorgens, H; Schackert, HK; van Krieken, JHJM; Ligtenberg, MJL; Hoogerbrugge, N; van Kessel, AG; Kuiper, RP,期刊:International Journal of Cancer, 页码:1635-1642 , 文章类型: Article,,卷期:2011年129-7]
- In the majority of colorectal cancers (CRCs) under clinical suspicion for a hereditary cause, the disease-causing genetic factors are still to be discovered. To identify such genetic factors we stringently selected a dis...
- [DLys(6)]-luteinizing hormone releasing hormone-curcumin conjugate inhibits pancreatic cancer cell growth in vitro and in vivo
[作者:Aggarwal, S; Ndinguri, MW; Solipuram, R; Wakamatsu, N; Hammer, RP; Ingram, D; Hansel, W,期刊:International Journal of Cancer, 页码:1611-1623 , 文章类型: Article,,卷期:2011年129-7]
- Pancreatic ductal adenocarcinomas are invariably lethal, and developing effective treatments that have minimal side effects is a challenge. Previous studies from our laboratory have shown that conjugates of cell membrane...
- 3,3 '-Diindolylmethane enhances Taxotere-induced growth inhibition of breast cancer cells through downregulation of FoxM1
[作者:Ahmad, A; Ali, S; Wang, ZW; Ali, AS; Sethi, S; Sakr, WA; Raz, A; Rahman, KMW,期刊:International Journal of Cancer, 页码:1781-1791 , 文章类型: Article,,卷期:2011年129-7]
- Emerging evidence suggests that the transcription factor Forkhead Box M1 (FoxM1) is associated with aggressive human carcinomas, including breast cancer. Because elevated expression of FoxM1 has been observed in human br...
- A candidate CpG SNP approach identifies a breast cancer associated ESR1-SNP
[作者:Harlid, S; Ivarsson, MIL; Butt, S; Hussain, S; Grzybowska, E; Eyfjord, JE; Lenner, P; Forsti, A; Hemminki, K; Manjer, J; Dillner, J; Carlson, J,期刊:International Journal of Cancer, 页码:1689-1698 , 文章类型: Article,,卷期:2011年129-7]
- Altered DNA methylation is often seen in malignant cells, potentially contributing to carcinogenesis by suppressing gene expression. We hypothesized that heritable methylation potential might be a risk factor for breast ...
- Association of low-risk MSH3 and MSH2 variant alleles with Lynch syndrome: probability of synergistic effects
[作者:Duraturo, F; Liccardo, R; Cavallo, A; De Rosa, M; Grosso, M; Izzo, P,期刊:International Journal of Cancer, 页码:1643-1650 , 文章类型: Article,,卷期:2011年129-7]
- Mutations in the MLH1 and MSH2 genes account for a majority of cases of families with Lynch Syndrome. Germ-line mutations in MSH6, PMS2 and MLH3 are responsible for disease in a minority of cases, usually associated with...
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