- High susceptibility to azoxymethane-induced colorectal carcinogenesis in obese KK-A(y) mice
[作者:Teraoka, N; Mutoh, M; Takasu, S; Ueno, T; Nakano, K; Takahashi, M; Imai, T; Masuda, S; Sugimura, T; Wakabayashi, K,期刊:International Journal of Cancer, 页码:528-535 , 文章类型: Article,,卷期:2011年129-3]
- Obesity is associated with colon carcinogenesis. However, not much information is available regarding the mechanisms of obesity-associated colorectal cancer, and there are only few useful animal models for investigating ...
- High RAD51 mRNA expression characterize estrogen receptor-positive/progesteron receptor-negative breast cancer and is associated with patient's outcome
[作者:Barbano, R; Copetti, M; Perrone, G; Pazienza, V; Muscarella, LA; Balsamo, T; Storlazzi, CT; Ripoli, M; Rinaldi, M; Valori, VM; Latiano, TP; Maiello, E; Stanziale, P; Carella, M; Mangia, A; Pellegrini, F; Bisceglia, M; Muda, AO; Altomare, V; Murgo, R; Fazio, VM; Parrella, P,期刊:International Journal of Cancer, 页码:536-545 , 文章类型: Article,,卷期:2011年129-3]
- Mutations in DNA double-strand breaks (DSB) repair genes are involved in the pathogenesis of hereditary mammary tumors, it is, however, still unclear whether defects in this pathway may play a role in sporadic breast can...
- Downregulation of Breast Cancer Resistance Protein in colon adenomas reduces cellular xenobiotic resistance and leads to accumulation of a food-derived carcinogen
[作者:Dietrich, CG; Vehr, AK; Martin, IV; Gassler, N; Rath, T; Roeb, E; Schmitt, J; Trautwein, C; Geier, A,期刊:International Journal of Cancer, 页码:546-552 , 文章类型: Article,,卷期:2011年129-3]
- Several molecular changes in colorectal adenomas provide the basis of the adenoma-carcinoma sequence. We investigated the expression of xenobiotic ATP-binding cassette (ABC) transporters in humans and in ApcMin mice and ...
- Overexpression of the dynein light chain km23-1 in human ovarian carcinoma cells inhibits tumor formation in vivo and causes mitotic delay at prometaphase/metaphase
[作者:Pulipati, NR; Jin, QY; Liu, X; Sun, BD; Zhao, Y; Pandey, MK; Huber, JP; Ding, W; Mulder, KM,期刊:International Journal of Cancer, 页码:553-564 , 文章类型: Article,,卷期:2011年129-3]
- km23-1 is a dynein light chain that was identified as a TGF beta receptor-interacting protein. To investigate whether km23-1 controls human ovarian carcinoma cell (HOCC) growth, we established a tet-off inducible express...
- The ECM protein LTBP-2 is a suppressor of esophageal squamous cell carcinoma tumor formation but higher tumor expression associates with poor patient outcome
[作者:Chan, SHK; Ko, JMY; Chan, KW; Chan, YP; Tao, Q; Hyytiainen, M; Keski-Oja, J; Law, S; Srivastava, G; Tang, J; Tsao, SW; Chen, H; Stanbridge, EJ; Lung, ML,期刊:International Journal of Cancer, 页码:565-573 , 文章类型: Article,,卷期:2011年129-3]
- Our previous studies of chromosome 14 transfer into tumorigenic esophageal squamous cell carcinoma (ESCC) cell line, SLMT, suggested the existence of tumor suppressor genes on chromosome 14. Gene expression profiling of ...
- Human glioblastoma-initiating cells invade specifically the subventricular zones and olfactory bulbs of mice after striatal injection
[作者:Kroonen, J; Nassen, J; Boulanger, YG; Provenzano, F; Capraro, V; Bours, V; Martin, D; Deprez, M; Robe, P; Rogister, B,期刊:International Journal of Cancer, 页码:574-585 , 文章类型: Article,,卷期:2011年129-3]
- In patients with glioblastoma multiforme, recurrence is the rule despite continuous advances in surgery, radiotherapy and chemotherapy. Within these malignant gliomas, glioblastoma stem cells or initiating cells have bee...
- Herpesvirus saimiri-based endothelin-converting enzyme-1 shRNA expression decreases prostate cancer cell invasion and migration
[作者:Hong, Y; Macnab, S; Lambert, LA; Turner, AJ; Whitehouse, A; Usmani, BA,期刊:International Journal of Cancer, 页码:586-598 , 文章类型: Article,,卷期:2011年129-3]
- The zinc metalloprotease, endothelin-converting enzyme-1 (ECE-1), which converts the mitogenic peptide endothelin-1 (ET-1) from its biologically inactive precursor big-ET-1, is commonly upregulated in prostate cancer (PC...
- An RNAi screen identifies USP2 as a factor required for TNF-alpha-induced NF-kappa B signaling
[作者:Metzig, M; Nickles, D; Falschlehner, C; Lehmann-Koch, J; Straub, BK; Roth, W; Boutros, M,期刊:International Journal of Cancer, 页码:607-618 , 文章类型: Article,,卷期:2011年129-3]
- Tumor necrosis factor alpha (TNF-alpha) signaling pathways play important roles during tumorigenesis and inflammation. Ubiquitin-dependent processes are central to the regulation of TNF-alpha and nuclear factor kappa B (...
- Association of Merkel cell polyomavirus infection with tumor p53, KIT, stem cell factor, PDGFR-alpha and survival in Merkel cell carcinoma
[作者:Waltari, M; Sihto, H; Kukko, H; Koljonen, V; Sankila, R; Bohling, T; Joensuu, H,期刊:International Journal of Cancer, 页码:619-628 , 文章类型: Article,,卷期:2011年129-3]
- Most Merkel cell carcinomas (MCCs) contain Merkel cell polyomavirus (MCPyV) DNA, and the virus likely has a pivotal role in tumor pathogenesis. p53 and the KIT receptor tyrosine kinase have also been implicated in MCC pa...
- LAPTM4B overexpression is a novel predictor of epithelial ovarian carcinoma metastasis
[作者:Yin, MZ; Xu, Y; Lou, G; Hou, Y; Meng, FL; Zhang, HY; Li, C; Zhou, RL,期刊:International Journal of Cancer, 页码:629-635 , 文章类型: Article,,卷期:2011年129-3]
- LAPTM4B is a novel tumor-associated gene. To date, there have been no published data regarding the role of LAPTM4B expression in epithelial ovarian carcinoma metastasis. Therefore, this study was performed to determine w...
- CD8(+)Foxp3(+) tumor infiltrating lymphocytes accumulate in the context of an effective anti-tumor response
[作者:Le, DT; Ladle, BH; Lee, T; Weiss, V; Yao, XS; Leubner, A; Armstrong, TD; Jaffee, EM,期刊:International Journal of Cancer, 页码:636-647 , 文章类型: Article,,卷期:2011年129-3]
- The composition of tumor infiltrating lymphocytes (TIL) is heterogeneous. In addition, the ratio of various subpopulations in the tumor microenvironment is highly dependent on the nature of the host's immune response. He...
- Promoter methylation and expression of MGMT and the DNA mismatch repair genes MLH1, MSH2, MSH6 and PMS2 in paired primary and recurrent glioblastomas
[作者:Felsberg, J; Thon, N; Eigenbrod, S; Hentschel, B; Sabel, MC; Westphal, M; Schackert, G; Kreth, FW; Pietsch, T; Loffler, M; Weller, M; Reifenberger, G; Tonn, JC,期刊:International Journal of Cancer, 页码:659-670 , 文章类型: Article,,卷期:2011年129-3]
- Epigenetic silencing of the O-6-methylguanine-DNA methyltransferase (MGMT) gene promoter is associated with prolonged survival in glioblastoma patients treated with temozolomide (TMZ). We investigated whether glioblastom...
- Economic evaluation of strategies for managing women with equivocal cytological results in Brazil
[作者:Vanni, T; Legood, R; Franco, EL; Villa, LL; Luz, PM; Schwartsmann, G,期刊:International Journal of Cancer, 页码:671-679 , 文章类型: Article,,卷期:2011年129-3]
- In Brazil, current management of women with screening results of atypical squamous cells of undetermined significance (ASC-US) is to offer repeat testing at 6-month intervals. Alternative management strategies that have ...
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