- Curcumin ameliorates oxaliplatin-induced chemoresistance in HCT116 colorectal cancer cells in vitro and in vivo
[作者:Howells, LM; Sale, S; Sriramareddy, SN; Irving, GRB; Jones, DJL; Ottley, CJ; Pearson, DG; Mann, CD; Manson, MM; Berry, DP; Gescher, A; Steward, WP; Brown, K,期刊:International Journal of Cancer, 页码:476-486 , 文章类型: Article,,卷期:2011年129-2]
- The aims of this study were to determine potency of oxaliplatin in combination with curcumin in oxaliplatin-resistant cell lines in vitro and to evaluate the efficacy of a novel curcumin formulation (Meriva (R)) alone an...
- Gold(III)-dithiocarbamato anticancer agents: activity, toxicology and histopathological studies in rodents
[作者:Marzano, C; Ronconi, L; Chiara, F; Giron, MC; Faustinelli, I; Cristofori, P; Trevisan, A; Fregona, D,期刊:International Journal of Cancer, 页码:487-496 , 文章类型: Article,,卷期:2011年129-2]
- Gold(III)-dithiocarbamato complexes have recently gained increasing attention as potential anticancer agents because of their strong tumor cell growth-inhibitory effects, generally achieved by exploiting non-cisplatin-li...
- Chimeric, divalent and tetravalent anti-CD19 monoclonal antibodies with potent in vitro and in vivo antitumor activity against human B-cell lymphoma and pre-B acute lymphoblastic leukemia cell lines
[作者:Liu, XY; Pop, LM; Tsai, L; Pop, IV; Vitetta, ES,期刊:International Journal of Cancer, 页码:497-506 , 文章类型: Article,,卷期:2011年129-2]
- CD19 is an attractive therapeutic target for treating human B-cell tumors. In our study, chimeric (c) divalent (cHD37) and tetravalent (cHD37-DcVV) anti-CD19 monoclonal antibodies (MAbs) were constructed, expressed and e...
- Sorafenib reduces the percentage of tumour infiltrating regulatory T cells in renal cell carcinoma patients
[作者:Desar, IME; Jacobs, JFM; Hulsbergen-vandeKaa, CA; Oyen, WJG; Mulders, PFA; van der Graaf, WTA; Adema, GJ; van Herpen, CML; de Vries, IJM,期刊:International Journal of Cancer, 页码:507-512 , 文章类型: Article,,卷期:2011年129-2]
- Tyrosine kinase inhibitors (TKIs) as sorafenib are known to reduce the number of immunosuppressive regulatory T cells (Tregs) in the peripheral blood and thereby shifting the immune balance to a more stimulating setting....
- Neonatal UVB exposure accelerates melanoma growth and enhances distant metastases in Hgf-Cdk4(R24C) C57BL/6 mice
[作者:Gaffal, E; Landsberg, J; Bald, T; Sporleder, A; Kohlmeyer, J; Tuting, T,期刊:International Journal of Cancer, 页码:285-294 , 文章类型: Article,,卷期:2011年129-2]
- Genetically engineered mouse models offer new opportunities to experimentally investigate the impact of UV on melanoma pathogenesis. Here we irradiated a cohort of newborn 15 Hgf-Cdk4(R24C) mice on the pigmented C57BL/6 ...
- Id3 modulates cellular localization of bHLH Ptf1-p48 protein
[作者:Dufresne, M; Clerc, P; Dieng, M; Edir, A; Couvelard, A; Delisle, MB; Fourmy, D; Gigoux, V,期刊:International Journal of Cancer, 页码:295-306 , 文章类型: Article,,卷期:2011年129-2]
- Ptf1-p48 is a pancreas-specific bHLH transcriptional protein, which, in the normal adult pancreas, shows a restricted expression in acinar cells where it is predominantly localized in the nucleus and activates the transc...
- Mesenchymal stromal cells from primary osteosarcoma are non-malignant and strikingly similar to their bone marrow counterparts
[作者:Brune, JC; Tormin, A; Johansson, MC; Rissler, P; Brosjo, O; Lofvenberg, R; von Steyern, FV; Mertens, F; Rydholm, A; Scheding, S,期刊:International Journal of Cancer, 页码:319-330 , 文章类型: Article,,卷期:2011年129-2]
- Mesenchymal stromal cells (MSC) are multipotent cells that can be isolated from a number of human tissues. In cancer, MSC have been implicated with tumor growth, invasion, metastasis, drug resistance and were even sugges...
- Zinc deficiency activates S100A8 inflammation in the absence of COX-2 and promotes murine oral-esophageal tumor progression
[作者:Wan, SG; Taccioli, C; Jiang, YB; Chen, HP; Smalley, KJ; Huang, K; Liu, XP; Farber, JL; Croce, CM; Fong, LYY,期刊:International Journal of Cancer, 页码:331-345 , 文章类型: Article,,卷期:2011年129-2]
- Zinc (Zn)-deficiency (ZD) is implicated in the pathogenesis of human oral-esophageal cancers. Previously, we showed that in ZD mice genetic deletion of cyclooxygenase-2 (Cox-2) enhances N-nitrosomethylbenzylamine-induced...
- The plasmacytoid carcinoma of the bladder-rare variant of aggressive urothelial carcinoma
[作者:Keck, B; Stoehr, R; Wach, S; Rogler, A; Hofstaedter, F; Lehmann, J; Montironi, R; Sibonye, M; Fritsche, HM; Lopez-Beltran, A; Epstein, JI; Wullich, B; Hartmann, A,期刊:International Journal of Cancer, 页码:346-354 , 文章类型: Article,,卷期:2011年129-2]
- The WHO 2004 classification defines new histological and molecular variants of urothelial carcinoma. However, there are limited data available on the clinicopathological characteristics or prognosis of these variants. We...
- Gene expression profiling reveals novel biomarkers in nonsmall cell lung cancer
[作者:Sanchez-Palencia, A; Gomez-Morales, M; Gomez-Capilla, JA; Pedraza, V; Boyero, L; Rosell, R; Farez-Vidal, ME,期刊:International Journal of Cancer, 页码:355-364 , 文章类型: Article,,卷期:2011年129-2]
- The development of reliable gene expression profiling technology is having an increasing impact on our understanding of lung cancer biology. Our study aimed to determine any correlation between the phenotypic heterogenei...
- A novel F-19 agent for detection and quantification of human dendritic cells using magnetic resonance imaging
[作者:Bonetto, F; Srinivas, M; Heerschap, A; Mailliard, R; Ahrens, ET; Figdor, CG; de Vries, IJM,期刊:International Journal of Cancer, 页码:365-373 , 文章类型: Article,,卷期:2011年129-2]
- Monitoring of cell therapeutics in vivo is of major importance to estimate its efficacy. Here, we present a novel intracellular label for F-19 magnetic resonance imaging (MRI)-based cell tracking, which allows for noninv...
- Synergistic effects of CTLA-4 blockade with tremelimumab and elimination of regulatory T lymphocytes in vitro and in vivo
[作者:Suarez, N; Alfaro, C; Dubrot, J; Palazon, A; Bolanos, E; Erro, L; Hervas-Stubbs, S; Martinez-Forero, I; Morales-Kastresana, A; Martin-Algarra, S; Sangro, B; Lecanda, F; Perez-Gracia, JL; Gonzalez, A; Melero, I,期刊:International Journal of Cancer, 页码:374-386 , 文章类型: Article,,卷期:2011年129-2]
- Anti-CTLA-4 monoclonal antibodies (mAb) that block the interaction of CTLA-4 with CD80 and CD86 such as tremelimumab and ipilimumab are currently being tested in the clinic for cancer treatment exploiting their propertie...
|