Gout is the most common form of inflammatory arthritis in men over 40 years of age. Available drugs target various steps to lower serum urate levels and include the xanthine oxidase inhibitors allopurinol and febuxostat,...
Linsitinib (OSI-906) is a novel, small-molecule, dual inhibitor of insulin-like growth factor 7 receptor (IGT-I receptor) and insulin receptor (IR). There is ample evidence that the ICE-I receptor is overexpressed in sev...
As an oncogene, hepatocyte growth factor receptor (proto-oncogene c-Met; MET) is known to be overexpressed and/or mutated in many types of cancer and plays a critical role in cancer cell survival, proliferation, angiogen...
Hunger contractions consist of a series of strong contractions of the stomach that evolve to phase Ill of the migrating motor complex and move down the small intestine. Ghrelin is considered to be important for the initi...
The idea for microbicides to prevent the transmission of sexually transmitted infections came from a discovery in the 1980s that over-the-counter spermicides showed antiviral activity in vitro. Since the advent of the HI...
Autaphagy is a process whereby cellular contents are captured in specialized membrane-bound vesicles and delivered to lysosomes for final degradation. Most studies support an inherent connection between autophagy and sur...