- The time is right: Proteome biology of stem cells
[作者：Whetton, AD; Williamson, AJK; Krijgsveld, J; Lee, BH; Lemischka, L; Oh, S; Pera, M; Mummery, C; Heck, AJR,期刊：Cell Stem Cell, 页码：215-217 , 文章类型： Article，,卷期：2008年2-3]
- In stem cell biology, there is a growing need for advanced technologies that may help to unravel the molecular mechanisms of self-renewal and differentiation. Proteomics, the comprehensive analysis of proteins, is such a...
- MicroRNA regulation of cell lineages in mouse and human embryonic stem cells
[作者：Ivey, KN; Muth, A; Amold, J; King, FW; Yeh, RF; Fish, JE; Hsiao, EC; Schwartz, RJ; Conklin, BR; Bernstein, HS; Srivastava, D,期刊：Cell Stem Cell, 页码：219-229 , 文章类型： Article，,卷期：2008年2-3]
- Cell fate decisions of pluripotent embryonic stem (ES) cells are dictated by activation and repression of lineage-specific genes. Numerous signaling and transcriptional networks progressively narrow and specify the poten...
- Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse
[作者：Stadtfeld, M; Maherali, N; Breault, DT; Hochedlinger, K,期刊：Cell Stem Cell, 页码：230-240 , 文章类型： Article，,卷期：2008年2-3]
- Ectopic expression of the transcription factors Oct4, Sox2, c-Myc, and Klf4 in fibroblasts generates induced pluripotent stem (iPS) cells. Little is known about the nature and sequence of molecular events accompanying nu...
- SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization
[作者：Han, MK; Song, EK; Guo, Y; Ou, X; Mantel, C; Broxmeyer, HE,期刊：Cell Stem Cell, 页码：241-251 , 文章类型： Article，,卷期：2008年2-3]
- Nuclear tumor suppressor p53 transactivates proapoptotic genes or antioxidant genes depending on stress severity, while cytoplasmic p53 induces mitochondrial-dependent apoptosis without gene transactivation. Although SIR...
- The emergence of hematopoietic stem cells is initiated in the placental vasculature in the absence of circulation
[作者：Rhodes, KE; Gekas, C; Wang, Y; Lux, CT; Francis, CS; Chan, DN; Conway, S; Orkin, SH; Yoder, MC; Mikkola, HKA,期刊：Cell Stem Cell, 页码：252-263 , 文章类型： Article，,卷期：2008年2-3]
- The mouse placenta was unveiled as an important reservoir for hematopoietic stem cells (HSCs), yet the origin of placental HSCs was unknown. By tracking developing HSCs by expression of Runx1-lacZ and CD41, we have found...
- Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo
[作者：Fleming, HE; Janzen, V; Lo Celso, C; Guo, J; Leahy, KM; Kronenberg, HM; Scadden, DT,期刊：Cell Stem Cell, 页码：274-283 , 文章类型： Article，,卷期：2008年2-3]
- Wingless (Wnt) is a potent morphogen demonstrated in multiple cell lineages to promote the expansion and maintenance of stem and progenitor cell populations. Writ effects are highly context dependent, and varying effects...
- Intrinsic epithelial cells repair the kidney after injury
[作者：Humphreys, BD; Valerius, MT; Kobayashi, A; Mugford, JW; Soeung, S; Duffield, JS; McMahon, AP; Bonventre, JV,期刊：Cell Stem Cell, 页码：284-291 , 文章类型： Article，,卷期：2008年2-3]
- Understanding the mechanisms of nephron repair is critical for the design of new therapeutic approaches to treat kidney disease. The kidney can repair after even a severe insult, but whether adult stem or progenitor cell...
- LIS1 and spindle orientation in neuroepithelial cells
[作者：Schwarnborn, JC; Knoblich, JA,期刊：Cell Stem Cell, 页码：193-194 , 文章类型： Editorial Material，,卷期：2008年2-3]
- Asymmetric stem cell division is thought to require precise orientation of the mitotic spindle. However, a recent study in Cell (Yingling et al., 2008) analyzes the role of LIS1 in the developing mouse brain and shows th...
- MicroRNA regulation of stem cell fate
[作者：Li, QT; Gregory, RI,期刊：Cell Stem Cell, 页码：195-196 , 文章类型： Editorial Material，,卷期：2008年2-3]
- MicroRNAs modulate target gene expression and are essential for normal development, but how does this pathway impact cell fate decisions? In this issue of Cell Stem Cell, Ivey et al. (2008) find that muscle-specific micr...
- Directing stem cell homing
[作者：Khaidoyanidi, S,期刊：Cell Stem Cell, 页码：198-200 , 文章类型： Editorial Material，,卷期：2008年2-3]
- Stem cell-based regeneration depends partly on the delivery of stem cells to the damaged area. Recently in Nature Medicine, Sackstein et al. (2008) report that ex vivo fucosylation of surface CD44 promoted efficient adhe...
- Cell delivery mechanisms for tissue repair
[作者：Mooney, DJ; Vandenburgh, H,期刊：Cell Stem Cell, 页码：205-213 , 文章类型： Review，,卷期：2008年2-3]
- Many cell populations, derived from both adult tissues and embryonic stem cells, show promise for the treatment of a variety of diseases. Although the major effort in stem cell therapies in the past has been identifying ...
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