- The use of fresh embryos in stem cell research ethical and policy issues
[作者：Cohen, CB; Brandhorst, B; Nagy, A; Leader, A; Dickens, B; Isasi, RM; Evans, D; Knoppers, BM,期刊：Cell Stem Cell, 页码：416-421 , 文章类型： Article，,卷期：2008年2-5]
- Fresh embryos resulting from in vitro fertilization, including many of poor quality, can provide sources of human embryonic stem cell lines. We consider why some donate such embryos for this research, address relevant et...
- Global transcription in pluripotent embryonic stem cells
[作者：Efroni, S; Duttagupta, R; Cheng, J; Dehghani, H; Hoeppner, DJ; Dash, C; Bazett-Jones, DP; Le Grice, S; Mckay, RDG; Buetow, KH; Gingeras, TR; Misteli, T; Meshorer, E,期刊：Cell Stem Cell, 页码：437-447 , 文章类型： Article，,卷期：2008年2-5]
- The molecular mechanisms underlying pluripotency and lineage specification from embryonic stem cells (ESCs) are largely unclear. Differentiation pathways may be determined by the targeted activation of lineage-specific g...
- A hierarchical network controls protein translation during murine embryonic stem cell self-renewal and differentiation
[作者：Sampath, P; Pritchard, DK; Pabon, L; Reinecke, H; Schwartz, SM; Morris, DR; Murry, CE,期刊：Cell Stem Cell, 页码：448-460 , 文章类型： Article，,卷期：2008年2-5]
- Stem cell differentiation involves changes in transcription, but little is known about translational control during differentiation. We comprehensively profiled gene expression during differentiation of murine embryonic ...
- Notch signaling activation in human embryonic stem cells is required for embryonic, but not trophoblastic, lineage commitment
[作者：Yu, XB; Zou, JZ; Ye, ZH; Hammond, H; Chen, GB; Tokunaga, A; Mali, P; Li, YM; Civin, C; Gaiano, N; Cheng, LZ,期刊：Cell Stem Cell, 页码：461-471 , 文章类型： Article，,卷期：2008年2-5]
- The Notch signaling pathway plays important roles in cell-fate determination during embryonic development and adult life. In this study, we focus on the role of Notch signaling in governing cell-fate choices in human emb...
- Brain area-specific effect of TGF-beta signaling on Wnt-dependent neural stem cell expansion
[作者：Falk, S; Wurdak, H; Ittner, LM; Ille, F; Sumara, G; Schmid, MT; Draganova, K; Lang, KS; Paratore, C; Leveen, P; Suter, U; Karlsson, S; Born, W; Ricci, R; Gotz, M; Sommer, L,期刊：Cell Stem Cell, 页码：472-483 , 文章类型： Article，,卷期：2008年2-5]
- Regulating the choice between neural stem cell maintenance versus differentiation determines growth and size of the developing brain. Here we identify TGF-beta signaling as a crucial factor controlling these processes. A...
- Pbx1 regulates self-renewal of long-term hematopoietic stem cells by maintaining their quiescence
[作者：Ficara, F; Murphy, MJ; Lin, M; Cleary, ML,期刊：Cell Stem Cell, 页码：484-496 , 文章类型： Article，,卷期：2008年2-5]
- Self-renewal is a defining characteristic of stem cells; however, the molecular pathways underlying its regulation are poorly understood. Here, we demonstrate that conditional inactivation of the Pbx1 proto-oncogene in t...
- ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification
[作者：Lee, D; Park, C; Lee, H; Lugus, JJ; Kim, SH; Arentson, E; Chung, YS; Gomez, G; Kyba, M; Lin, S; Janknecht, R; Lim, DS; Choi, K,期刊：Cell Stem Cell, 页码：497-507 , 文章类型： Article，,卷期：2008年2-5]
- FLK1-expressing (FLK1(+)) mesoderm generates blood and vessels. Here, we show that combined BMP, Notch, and Wnt signaling is necessary for efficient FLK1(+) mesoderm formation from embryonic stem cells (ESCs). Inhibition...
- Manipulating midbrain stem cell self-renewal
[作者：LoTurco, JJ; Kriegstein, AR,期刊：Cell Stem Cell, 页码：405-406 , 文章类型： Editorial Material，,卷期：2008年2-5]
- In this issue of Cell Stem Cell, Falk and colleagues (Falk et al., 2008) demonstrate that differential responsiveness to TGF-beta signaling selectively modulates self-renewal of dorsal midbrain stem cells. This observati...
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