Protein arginine N-methyltransferases (PRMTs) catalyze the post-translational methylation of arginine residues within substrate proteins. Their roles in the epigenetic regulation of gene expression make them viable targe...
The study of dynamic properties of metabolic and signaling networks is hindered by the lack of methods for imaging metabolic fluxes in individual intact cells. We describe a novel optical approach for measuring the chang...
Insulin signaling has been suggested, at least in part, to be affected by an insulin-mimetic species of low molecular weight. These inositol phos-phoglycans (IPGs) are generated upon growth hormone/cytokine stimulation a...
Bone marrow stromal cells (BMSCs) play critical roles in repairing endothelium damage. However, the mechanisms underlying BMSC differentiation Into vascular endothelial cells (VECs) is not well understood. We aimed to fi...
The retinoic acid receptor-related receptors (RORs) are members of the nuclear receptor (NR) superfamily of transcription factors. Several NRs are still characterized as orphan receptors because ligands have not yet been...
Aurora kinases are key regulators of cell division and important targets for cancer therapy. We report that Binuclelne 2 Is a highly isoform-specific Inhibitor of Drosophila Aurora B kinase, and we identify a single resi...
Thiopurines are effective immuno-suppressants and anticancer agents. However, the long-term use of thiopurines was found to be associated with a significantly increased risk of various types of cancer. To date, the speci...
In situ click chemistry has been successfully applied to probe the ligand binding domain of EthR, a mycobacterial transcriptional regulator known to control the sensitivity of Mycobacterium tuberculosis to several antibi...
We report here a new small molecule fluorogen and RNA aptamer pair for RNA labeling. The small-molecule fluorogen Is designed on the basis of fluorescently quenched sulforhodamine dye. The SELEX (Systematic Evolution of ...