- Retinol-Binding Protein 4 Inhibits Insulin Signaling in Adipocytes by Inducing Proinflammatory Cytokines in Macrophages through a c-Jun N-Terminal Kinase- and Toll-Like Receptor 4-Dependent and Retinol-Independent Mechanism
[作者:Norseen, J; Hosooka, T; Hammarstedt, A; Yore, MM; Kant, S; Aryal, P; Kiernan, UA; Phillips, DA; Maruyama, H; Kraus, BJ; Usheva, A; Davis, RJ; Smith, U; Kahn, BB,期刊:Molecular and Cellular Biology, 页码:2010-2019 , 文章类型: Article,,卷期:2012年32-10]
- Retinol-binding protein 4 (RBP4), the sole retinol transporter in blood, is secreted from adipocytes and liver. Serum RBP4 levels correlate highly with insulin resistance, other metabolic syndrome factors, and cardiovasc...
- Scd1 Plays a Tumor-Suppressive Role in Survival of Leukemia Stem Cells and the Development of Chronic Myeloid Leukemia
[作者:Zhang, HJ; Li, HW; Ho, N; Li, DG; Li, SG,期刊:Molecular and Cellular Biology, 页码:1776-1787 , 文章类型: Article,,卷期:2012年32-10]
- Chronic myeloid leukemia (CML) is derived from a stem cell, and it is widely accepted that the existence of leukemia stem cells (LSCs) is one of the major reasons for the relapse of CML treated with kinase inhibitors. Ke...
- A Collapsin Response Mediator Protein 2 Isoform Controls Myosin II-Mediated Cell Migration and Matrix Assembly by Trapping ROCK II
[作者:Yoneda, A; Morgan-Fisher, M; Wait, R; Couchman, JR; Wewer, UM,期刊:Molecular and Cellular Biology, 页码:1788-1804 , 文章类型: Article,,卷期:2012年32-10]
- Collapsin response mediator protein 2 (CRMP-2) is known as a regulator of neuronal polarity and differentiation through microtubule assembly and trafficking. Here, we show that CRMP-2 is ubiquitously expressed and a spli...
- Analysis of Chromatin Dynamics during Glucocorticoid Receptor Activation
[作者:Burd, CJ; Ward, JM; Crusselle-Davis, VJ; Kissling, GE; Phadke, D; Shah, RR; Archer, TK,期刊:Molecular and Cellular Biology, 页码:1805-1817 , 文章类型: Article,,卷期:2012年32-10]
- Steroid hormone receptors initiate a genetic program tightly regulated by the chromatin environment of the responsive regions. Using the glucocorticoid receptor (GR) as a model factor for transcriptional initiation, we c...
- Tumor Suppressor PDCD4 Represses Internal Ribosome Entry Site-Mediated Translation of Antiapoptotic Proteins and Is Regulated by S6 Kinase 2
[作者:Liwak, U; Thakor, N; Jordan, LE; Roy, R; Lewis, SM; Pardo, OE; Seckl, M; Holcik, M,期刊:Molecular and Cellular Biology, 页码:1818-1829 , 文章类型: Article,,卷期:2012年32-10]
- Apoptosis can be regulated by extracellular signals that are communicated by peptides such as fibroblast growth factor 2 (FGF-2) that have important roles in tumor cell proliferation. The prosurvival effects of FGF-2 are...
- Cardiac Expression of ms1/STARS, a Novel Gene Involved in Cardiac Development and Disease, Is Regulated by GATA4
[作者:Ounzain, S; Kobayashi, S; Peterson, RE; He, AB; Motterle, A; Samani, NJ; Menick, DR; Pu, WT; Liang, QR; Chong, NW,期刊:Molecular and Cellular Biology, 页码:1830-1843 , 文章类型: Article,,卷期:2012年32-10]
- Ms1/STARS is a novel muscle-specific actin-binding protein that specifically modulates the myocardin-related transcription factor (MRTF)-serum response factor (SRF) regulatory axis within striated muscle. This ms1/STARS-...
- The Nucleosome Binding Protein HMGN1 Interacts with PCNA and Facilitates Its Binding to Chromatin
[作者:Postnikov, YV; Kurahashi, T; Zhou, M; Bustin, M,期刊:Molecular and Cellular Biology, 页码:1844-1854 , 文章类型: Article,,卷期:2012年32-10]
- Proliferating cell nuclear antigen (PCNA) is a ubiquitous protein that interacts with multiple partners and regulates nuclear activities, including chromatin assembly, histone modifications, replication, and DNA damage r...
- The Role of Ceroid Lipofuscinosis Neuronal Protein 5 (CLN5) in Endosomal Sorting
[作者:Mamo, A; Jules, F; Dumaresq-Doiron, K; Costantino, S; Lefrancois, S,期刊:Molecular and Cellular Biology, 页码:1855-1866 , 文章类型: Article,,卷期:2012年32-10]
- Mutations in the gene encoding CLN5 are the cause of Finnish variant late infantile Neuronal Ceroid Lipofuscinosis (NCL), and the gene encoding CLN5 is 1 of 10 genes (encoding CLN1 to CLN9 and cathepsin D) whose germ lin...
- Shp2 Controls Female Body Weight and Energy Balance by Integrating Leptin and Estrogen Signals
[作者:He, Z; Zhang, SS; Meng, QY; Li, SW; Zhu, HH; Raquil, MA; Alderson, N; Zhang, H; Wu, JR; Rui, LY; Cai, DS; Feng, GS,期刊:Molecular and Cellular Biology, 页码:1867-1878 , 文章类型: Article,,卷期:2012年32-10]
- In mammals, leptin regulates food intake and energy balance mainly through the activation of LepRb in the hypothalamus, and estrogen has a leptin-like effect in the hypothalamic control of metabolism. However, it remains...
- Inhibition of Mcl-1 Promotes Senescence in Cancer Cells: Implications for Preventing Tumor Growth and Chemotherapy Resistance
[作者:Bolesta, E; Pfannenstiel, LW; Demelash, A; Lesniewski, ML; Tobin, M; Schlanger, SE; Nallar, SC; Papadimitriou, JC; Kalvakolanu, DV; Gastman, BR,期刊:Molecular and Cellular Biology, 页码:1879-1892 , 文章类型: Article,,卷期:2012年32-10]
- Although senescence in oncogenesis has been widely studied, little is known regarding the role of this process in chemotherapy resistance. Thus, from the standpoint of enhancing and improving cancer therapy, a better und...
- Glucose Oxidation Modulates Anoikis and Tumor Metastasis
[作者:Kamarajugadda, S; Stemboroski, L; Cai, QS; Simpson, NE; Nayak, S; Tan, M; Lu, JR,期刊:Molecular and Cellular Biology, 页码:1893-1907 , 文章类型: Article,,卷期:2012年32-10]
- Cancer cells exhibit altered glucose metabolism characterized by a preference for aerobic glycolysis or the Warburg effect, and the cells resist matrix detachment-induced apoptosis, which is called anoikis, a barrier to ...
- A Critical Role for the Wnt Effector Tcf4 in Adult Intestinal Homeostatic Self-Renewal
[作者:van Es, JH; Haegebarth, A; Kujala, P; Itzkovitz, S; Koo, BK; Boj, SF; Korving, J; van den Born, M; van Oudenaarden, A; Robine, S; Clevers, H,期刊:Molecular and Cellular Biology, 页码:1918-1927 , 文章类型: Article,,卷期:2012年32-10]
- Throughout life, intestinal Lgr5(+) stem cells give rise to proliferating transient amplifying cells in crypts, which subsequently differentiate into one of the five main cell types and migrate along the crypt-villus axi...
- Klotho Coreceptors Inhibit Signaling by Paracrine Fibroblast Growth Factor 8 Subfamily Ligands
[作者:Goetz, R; Ohnishi, M; Ding, XS; Kurosu, H; Wang, L; Akiyoshi, J; Ma, JH; Gai, WM; Sidis, Y; Pitteloud, N; Kuro-o, M; Razzaque, MS; Mohammadi, M,期刊:Molecular and Cellular Biology, 页码:1944-1954 , 文章类型: Article,,卷期:2012年32-10]
- It has been recently established that Klotho coreceptors associate with fibroblast growth factor (FGF) receptor tyrosine kinases (FGFRs) to enable signaling by endocrine-acting FGFs. However, the molecular interactions l...
|