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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共23条记录   Evaluation of [C-11]N-Methyl Lansoprazole as a Radiopharmaceutical for PET Imaging of Tau Neurofibrillary Tangles [作者：SHAO XIA; CARPENTER GARRETT M; DESMOND TIMOTHY J; SHERMAN PHILLIP; QUESADA CAROLE A; FAWAZ MARIA; BROOKS ALLEN F; KILBOURN MICHAEL R; ALBIN ROGER L; FREY KIRK A; SCOTT PETER J H,期刊：ACS Medicinal Chemistry Letters, 页码：936-941 , 文章类型： Article，,卷期：2012年3-11] [C-11]N-Methyl lansoprazole ([C-11]NML, 3) was synthesized and evaluated as a radiopharmaceutical for quantifying tau neurofibrillary tangle (NFT) burden using positron emission tomography (PET) imaging. [C-11]NML was sy... Bivalent Ligands Targeting Multiple Pathological Factors Involved in Alzheimer's Disease [作者：LIU KAI; GANDHI RONAK; CHEN JIANGMIN; ZHANG SHIJUN,期刊：ACS Medicinal Chemistry Letters, 页码：942-946 , 文章类型： Article，,卷期：2012年3-11] In a continuing effort to develop multifunctional compounds as potential treatment agents for Alzheimer's disease (AD), a series of bivalent ligands containing curcumin and cholesterylamine were designed, synthesized, an... Approaches Toward New Alzheimer's Treatments [作者：VACCA JOSEPH P,期刊：ACS Medicinal Chemistry Letters, 页码：861-861 , 文章类型： Editorial Material，,卷期：2012年3-11] "It Ain't Over 'til It's Over"-The Search for Treatments and Cures for Alzheimer's Disease [作者：HARGREAVES RICHARD J,期刊：ACS Medicinal Chemistry Letters, 页码：862-866 , 文章类型： Editorial Material，,卷期：2012年3-11] In the neuroscience landscape, there is no condition with higher unmet medical and societal need than Alzheimer's disease (AD). There are significant opportunities to improve upon symptomatic treatments in AD, and as yet... BACE Inhibitors: Potential Treatment of Alzheimer's Disease, Dementia, and Related Neurodegenerative Disorders (A): 5,6-Dihydroimidazo[1,2-a]pyrazin-8-yl-amine Derivatives [作者：ABDELMAGID AHMED F,期刊：ACS Medicinal Chemistry Letters, 页码：867-868 , 文章类型： Editorial Material，,卷期：2012年3-11] BACE Inhibitors: Potential Treatment of Alzheimer's Disease, Dementia, and Related Neurodegenerative Disorders (B): 3-Amino-4-fluoro-1H-isoindol Derivatives [作者：ABDELMAGID AHMED F,期刊：ACS Medicinal Chemistry Letters, 页码：869-870 , 文章类型： Editorial Material，,卷期：2012年3-11] BACE-Inhibitors: Potential Treatment of Alzheimer Disease, Dementia, and Related Neurodegenerative Diseases. C. Spiro-Heterocyclic Derivatives [作者：ABDELMAGID AHMED F,期刊：ACS Medicinal Chemistry Letters, 页码：871-872 , 文章类型： Editorial Material，,卷期：2012年3-11] 5-Amino-oxazepine and 5-Amino-thiazepine Compounds as beta-Secretase Antagonists and Methods of Use [作者：BLASS BENJAMIN,期刊：ACS Medicinal Chemistry Letters, 页码：873-874 , 文章类型： Editorial Material，,卷期：2012年3-11] Compounds and Their Use as BACE Inhibitors [作者：BLASS BENJAMIN,期刊：ACS Medicinal Chemistry Letters, 页码：875-876 , 文章类型： Editorial Material，,卷期：2012年3-11] Novel Indolethylbenzamides for the Treatment of Tauopathies [作者：ROSSE GERARD,期刊：ACS Medicinal Chemistry Letters, 页码：877-878 , 文章类型： Editorial Material，,卷期：2012年3-11] Novel and Selective Inhibitors of Histone Deacetylase [作者：ROSSE GERARD,期刊：ACS Medicinal Chemistry Letters, 页码：879-880 , 文章类型： Editorial Material，,卷期：2012年3-11] Benzenesulfonyl and Benzenesulfonamide as Modulators of the 5-HT6 Receptor [作者：ROSSE GERARD,期刊：ACS Medicinal Chemistry Letters, 页码：881-882 , 文章类型： Editorial Material，,卷期：2012年3-11] Novel Benzoisoxazole as Partial Agonist of the 5-HT4 Receptor [作者：ROSSE GERARD,期刊：ACS Medicinal Chemistry Letters, 页码：883-883 , 文章类型： Editorial Material，,卷期：2012年3-11] Novel Quinolinones as Activators of AMP Activated Protein Kinase [作者：ROSSE GERARD,期刊：ACS Medicinal Chemistry Letters, 页码：884-885 , 文章类型： Editorial Material，,卷期：2012年3-11] A Potent and Orally Efficacious, Hydroxyethylamine-Based Inhibitor of beta-Secretase [作者：KALLER MATTHEW R; HARRIED SCOTT S; ALBRECHT BRIAN; AMARANTE PATRICIA; BABUKHAN SAFURA; BARTBERGER MICHAEL D; BROWN JAMES; BROWN RYAN; CHEN KUI; CHENG YUAN; CITRON MARTIN; CROGHAN MICHAEL D; GRACEFFA RUSSELL; HICKMAN DEAN; JUDD TED; KRIEMEN CHUCK; LA DANIEL; LI VIVIAN; LOPEZ PATRICIA; LUO YI; MASSE CRAIG; MONENSCHEIN HOLGER; NGUYEN THOMAS; PENNINGTON LEWIS D; MIGUEL TISHA SAN; SICKMIER E ALLEN; WAHL ROBERT C; WEISS MATTHEW M; WEN PAUL H; WILLIAMSON TONI; WOOD STEPHEN; XUE MAY; YANG BRYANT; ZHANG JIANHUA; PATEL VINOD; ZHONG WENGE; HITCHCOCK STEPHEN,期刊：ACS Medicinal Chemistry Letters, 页码：886-891 , 文章类型： Article，,卷期：2012年3-11] beta-Secretase inhibitors are potentially disease-modifying treatments for Alzheimer's disease. Previous efforts in our laboratory have resulted in hydroxyethylamine-derived inhibitors such as 1 with low nanomolar potenc... Discovery of SCH 900229, a Potent Presenilin 1 Selective gamma-Secretase Inhibitor for the Treatment of Alzheimer's Disease [作者：WU WENLIAN; DOMALSKI MARTIN; BURNETT DUANE A; JOSIEN HUBERT; BARA THOMAS; RAJAGOPALAN MURALI; XU RUO; CLADER JOHN; GREENLEE WILLIAM J; BRUNSKILL ANDREW; HYDE LYNN A; DEL VECCHIO ROBERT A; COHENWILLIAMS MARY E; SONG LIXIN; LEE JULIE; TERRACINA GIUSEPPE; ZHANG QI; NOMEIR AMIN; PARKER ERIC M; ZHANG LILI,期刊：ACS Medicinal Chemistry Letters, 页码：892-896 , 文章类型： Article，,卷期：2012年3-11] An exploration of the SAR of the side chain of a novel tricyclic series of gamma-secretase inhibitors led to the identification of compound (-)-16 (SCH 900229), which is a potent and PSI selective inhibitor of gamma-secr...