- Dehydrocostuslactone, a Medicinal Plant-Derived Sesquiterpene Lactone, Induces Apoptosis Coupled to Endoplasmic Reticulum Stress in Liver Cancer Cells
[作者:Hsu, YL; Wu, LY; Kuo, PL,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:808-819 , 文章类型: Article,,卷期:2009年329-2]
This study is the first to investigate the anticancer effect of dehydrocostuslactone [DHE (3aS, 6aR, 9aR, 9bS)-decahydro3,6,9-tris(methylene) azuleno[4,5-b]furan-2(3H)-one)], a medicinal plant-derived sesquiterpene la...
- Rho Kinase Inhibitors Prevent Endothelium-Dependent Contractions in the Rat Aorta
[作者:Chan, CKY; Mak, JC; Man, RYK; Vanhoutte, PM,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:820-826 , 文章类型: Article,,卷期:2009年329-2]
Rho kinase is involved in the pathogenesis of hypertension, which favors the occurrence of endothelium-dependent contractions. The present study was designed to determine the effects of two Rho kinase inhibitors, HA10...
- Altered Responses to Propofol, but Not Ketamine, in Mice Deficient in the 65-Kilodalton Isoform of Glutamate Decarboxylase
[作者:Kubo, K; Nishikawa, K; Hardy-Yamada, M; Ishizeki, J; Yanagawa, Y; Saito, S,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:592-599 , 文章类型: Article,,卷期:2009年329-2]
GABA is synthesized by two isoforms of glutamate decarboxylase (GAD), GAD65, and GAD67. However, the relative contributions of GAD65-mediated GABA synthesis to the in vivo actions of anesthetics remain unknown. To add...
- Carisoprodol-Mediated Modulation of GABA(A) Receptors: In Vitro and in Vivo Studies
[作者:Gonzalez, LA; Gatch, MB; Taylor, CM; Bell-Horner, CL; Forster, MJ; Dillon, GH,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:827-837 , 文章类型: Article,,卷期:2009年329-2]
Carisoprodol is a frequently prescribed muscle relaxant. In recent years, this drug has been increasingly abused. The effects of carisoprodol have been attributed to its metabolite, meprobamate, a controlled substance...
- Evidence that hydrogen sulfide exerts antinociceptive effects in the gastrointestinal tract by activating K-ATP channels (vol 316, pg 325, 2006)
[作者:Distrutti, E; Sediari, L; Mencarelli, A; Renga, B; Orlandi, S; Antonelli, E; Roviezzo, F; Morelli, A; Cirino, G; Wallace, JL; Fiorucci, S,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:848-848 , 文章类型: Correction,,卷期:2009年329-2]
- Nitric oxide (NO)-releasing naproxen (HCT-3012 [(S)-6-methoxy-alpha-methyl-2-naphthaleneacetic acid 4-(nitrooxy)butyl ester]) interactions with aspirin in gastric mucosa of arthritic rats reveal a role for aspirin-triggered lipoxin, prostaglandins, and NO in gastric protection (vol 311, pg 1264, 2004)
[作者:Fiorucci, S; Di Lorenzo, A; Renga, B; Farneti, S; Morelli, A; Cirino, G,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:848-848 , 文章类型: Correction,,卷期:2009年329-2]
- A farnesoid X receptor-small heterodimer partner regulatory cascade modulates tissue metalloproteinase inhibitor-1 and matrix metalloprotease expression in hepatic stellate cells and promotes resolution of liver fibrosis (vol 314, pg 584, 2005)
[作者:Fiorucci, S; Rizzo, G; Antonelli, A; Renga, B; Mencarelli, A; Riccardi, L; Orlandi, S; Pruzanski, P; Morelli, A; Pellicciari, R,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:848-848 , 文章类型: Correction,,卷期:2009年329-2]
- Cross-talk between farnesoid-X-receptor (FXR) and peroxisome proliferator-activated receptor gamma contributes to the antifibrotic activity of FXR ligands in rodent models of liver cirrhosis (vol 315, pg 58, 2005)
[作者:Fiorucci, S; Rizzo, G; Antonelli, E; Renga, B; Mencarelli, A; Riccardi, L; Morelli, A; Pruzanski, M; Pellicciari, R,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:848-848 , 文章类型: Correction,,卷期:2009年329-2]
- Cooperation between aspirin-triggered lipoxin and nitric oxide (NO) mediates antiadhesive properties of 2-(acetyloxy)benzoic acid 3-(nitrooxymethyl)phenyl ester (NCX-4016) (NO-aspirin) on neutrophil-endothelial cell adherence (vol 309, pg 1174, 2008)
[作者:Fiorucci, S; Distrutti, E; Mencarelli, A; Rizzo, G; Di Lorenzo, AR; Baldoni, M; del Soldato, P; Morelli, A; Wallace, JL,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:848-848 , 文章类型: Correction,,卷期:2009年329-2]
- Involution of Collagen-Induced Arthritis with an Angiogenesis Inhibitor, PPI-2458
[作者:Brahn, E; Schoettler, N; Lee, S; Banquerigo, ML,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:615-624 , 文章类型: Article,,卷期:2009年329-2]
Pannus formation, in both rheumatoid arthritis (RA) and collagen-induced arthritis (CIA), is angiogenesis-dependent. PPI-2458 [(1R)-1-carbamoyl-2-methyl]-carbamic acid-(3R,3S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-...
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