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  • Secondary Structure of Huntingtin Amino-Terminal Region
    [作者:Kim, MW; Chelliah, Y; Kim, SW; Otwinowski, Z; Bezprozvanny, I,期刊:Structure, 页码:1205-1212 , 文章类型: Article,,卷期:2009年17-9]
  • Huntington's disease is a genetic neurodegenerative disorder resulting from polyglutamine (polyQ) expansion (>36Q) within the first exon of Huntingtin (Htt) protein. We applied X-ray crystallography to determine the seco...
  • Insights into How Nucleotide-Binding Domains Power ABC Transport
    [作者:Newstead, S; Fowler, PW; Bilton, P; Carpenter, EP; Sadler, PJ; Campopiano, DJ; Sansom, MSP; Iwata, S,期刊:Structure, 页码:1213-1222 , 文章类型: Article,,卷期:2009年17-9]
  • The mechanism by which nucleotide-binding domains (NBDs) of ABC transporters power the transport of substrates across cell membranes is currently unclear. Here we report the crystal structure of an NBD, FbpC, from the Ne...
  • Probing the "Dark Matter" of Protein Fold Space
    [作者:Taylor, WR; Chelliah, V; Hollup, SM; MacDonald, JT; Jonassen, I,期刊:Structure, 页码:1244-1252 , 文章类型: Article,,卷期:2009年17-9]
  • We used a protein structure prediction method to generate a variety of folds as alpha-carbon models with realistic secondary structures and good hydrophobic packing. The prediction method used only idealized constructs t...
  • Structural Polymorphism of the ParM Filament and Dynamic Instability
    [作者:Galkin, VE; Orlova, A; Rivera, C; Mullins, RD; Egelman, EH,期刊:Structure, 页码:1253-1264 , 文章类型: Article,,卷期:2009年17-9]
  • Segregation of the R1 plasmid in bacteria relies on ParM, an actin homolog that segregates plasmids by switching between cycles of polymerization and depolymerization. We find similar polymerization kinetics and stabilit...
  • Structural Dynamics of Light-Driven Proton Pumps
    [作者:Andersson, M; Malmerberg, E; Westenhoff, S; Katona, G; Cammarata, M; Wohri, AB; Johansson, LC; Ewald, F; Eklund, M; Wulff, M; Davidsson, J; Neutze, R,期刊:Structure, 页码:1265-1275 , 文章类型: Article,,卷期:2009年17-9]
  • Bacteriorhodopsin and proteorhodopsin are simple heptahelical proton pumps containing a retinal chromophore covalently bound to helix G via a protonated Schiff base. Following the absorption of a photon, all-trans retina...