- Structure of the Noncatalytic Domains and Global Fold of the Protein Disulfide Isomerase ERp72
[作者:Kozlov, G; Maattanen, P; Schrag, JD; Hura, GL; Gabrielli, L; Cygler, M; Thomas, DY; Gehring, K,期刊:Structure, 页码:651-659 , 文章类型: Article,,卷期:2009年17-5]
- Protein disulfide isomerases are a family of proteins that catalyze the oxidation and isomerization of disulfide bonds in newly synthesized proteins in the endoplasmic reticulum. The family includes general enzymes such ...
- Autoinhibitory Interactions between the PDZ2 and C-terminal Domains in the Scaffolding Protein NHERF1
[作者:Cheng, H; Li, JQ; Fazlieva, R; Dai, ZP; Bu, ZM; Roder, H,期刊:Structure, 页码:660-669 , 文章类型: Article,,卷期:2009年17-5]
- Na+/H+ exchanger regulatory factor (NHERF1) is a signaling adaptor protein comprising two PDZ domains and a C-terminal ezrin-binding (EB) motif. To understand the role of intramolecular interactions in regulating its bin...
- Polymerase Translocation with Respect to Single-Stranded Nucleic Acid: Looping or Wrapping of Primer around a Poly(A) Polymerase
[作者:Li, CZ; Li, HY; Zhou, SF; Sun, E; Yoshizawa, J; Poulos, TL; Gershon, PD,期刊:Structure, 页码:680-689 , 文章类型: Article,,卷期:2009年17-5]
- Vaccinia virus protein VP55 translocates continuously with respect to single-stranded nucleic acid while extending its 3'end. Here, all key sites of polymerase-primer interaction were identified, demonstrating the wrappi...
- Crystal Structures of Two Archaeal 8-Oxoguanine DNA Glycosylases Provide Structural Insight into Guanine/8-Oxoguanine Distinction
[作者:Faucher, F; Duclos, S; Bandaru, V; Wallace, SS; Doublie, S,期刊:Structure, 页码:703-712 , 文章类型: Article,,卷期:2009年17-5]
Among the four DNA bases, guanine is particularly vulnerable to oxidative damage and the most common oxidative product, 7,8-dihydro-8-oxoguanine (8-oxoG), is the most prevalent lesion observed in DNA molecules. Fortun...
- Conserved Cysteine Residues of GidA Are Essential for Biogenesis of 5-Carboxymethylaminomethyluridine at tRNA Anticodon
[作者:Osawa, T; Ito, K; Inanaga, H; Nureki, O; Tomita, K; Numata, T,期刊:Structure, 页码:713-724 , 文章类型: Article,,卷期:2009年17-5]
- The 5-carboxymethylaminomethyl modification of uridine (cmnm(5)U) at the anticodon first position occurs in tRNAs that read split codon boxes ending with purine. This modification is crucial for correct translation, by r...
- Impact of Conformational Heterogeneity of OxoG Lesions and Their Pairing Partners on Bypass Fidelity by Y Family Polymerases
[作者:Rechkoblit, O; Malinina, L; Cheng, Y; Geacintov, NE; Broyde, S; Patel, DJ,期刊:Structure, 页码:725-736 , 文章类型: Article,,卷期:2009年17-5]
- 7,8-Dihydro-8-oxoguanine (oxoG), the predominant oxidative DNA damage lesion, is processed differently by high-fidelity and Y-family lesion bypass polymerases. Although high-fidelity polymerases extend predominantly from...
- Proton-Linked Dimerization of a Retroviral Capsid Protein Initiates Capsid Assembly
[作者:Bailey, GD; Hyun, JK; Mitra, AK; Kingston, RL,期刊:Structure, 页码:737-748 , 文章类型: Article,,卷期:2009年17-5]
- In mature retroviral particles, the capsid protein (CA) forms a shell encasing the viral replication complex. Human immunodeficiency virus (HIV) CA dimerizes in solution, through its C-terminal domain (CTD), and this int...
- Structural Mechanism of SDS-Induced Enzyme Activity of Scorpion Hemocyanin Revealed by Electron Cryomicroscopy
[作者:Cong, Y; Zhang, QF; Woolford, D; Schweikardt, T; Khant, H; Dougherty, M; Ludtke, SJ; Chiu, W; Decker, H,期刊:Structure, 页码:749-758 , 文章类型: Article,,卷期:2009年17-5]
- Phenoloxidases (POs) occur in all organisms and are involved in skin and hair coloring in mammals, and initiating melanization in wound healing. Mutation or overexpression of PO can cause albinism or melanoma, respective...
- Plant Photosystem I Design in the Light of Evolution
[作者:Amunts, A; Nelson, N,期刊:Structure, 页码:637-650 , 文章类型: Review,,卷期:2009年17-5]
- Photosystem I (PSI) is a membrane protein complex that catalyzes sunlight-driven transmembrane electron transfer as part of the photosynthetic machinery. Photosynthetic organisms appeared on the Earth about 3.5 billion y...
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