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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共15条记录   Genetic Encoding of 3-lodo-L-Tyrosine in Escherichia coli for Single-Wavelength Anomalous Dispersion Phasing in Protein Crystallography [作者：Sakamoto, K; Murayama, K; Oki, K; Lraha, F; Kato-Murayama, M; Takahashi, M; Ohtake, K; Kobayashi, T; Kuramitsu, S; Shirouzu, M; Yokoyama, S,期刊：Structure, 页码：335-344 , 文章类型： Article，,卷期：2009年17-3] We developed an Escherichia coli cell-based system to generate proteins containing 3-iodo-L-tyrosine at desired sites, and we used this system for structure determination by single-wavelength anomalous dispersion (SAD) p... Reverse Micelles in Integral Membrane Protein Structural Biology by Solution NMR Spectroscopy [作者：Kielec, JM; Valentine, KG; Babu, CR; Wand, AJ,期刊：Structure, 页码：345-351 , 文章类型： Article，,卷期：2009年17-3] Integral membrane proteins remain a significant challenge to structural studies by solution NMR spectroscopy. This is due not only to spectral complexity, but also because the effects of slow molecular reorientation are ... Kinase Domain Insertions Define Distinct Roles of CLK Kinases in SR Protein Phosphorylation [作者：Bullock, AN; Das, S; Debreczeni, JE; Rellos, P; Fedorov, O; Niesen, FH; Guo, K; Papagrigoriou, E; Amos, AL; Cho, S; Turk, BE; Ghosh, G; Knapp, S,期刊：Structure, 页码：352-362 , 文章类型： Article，,卷期：2009年17-3] Splicing requires reversible phosphorylation of serine/arginine-rich (SR) proteins, which direct splice site selection in eukaryotic mRNA. These phosphorylation events are dependent on SR protein (SRPK) and cdc2-like kin... Mapping the Initiator Binding Taf2 Subunit in the Structure of Hydrated Yeast TFIID [作者：Papai, G; Tripathi, MK; Ruhlmann, C; Werten, S; Crucifix, C; Weil, PA; Schultz, P,期刊：Structure, 页码：363-373 , 文章类型： Article，,卷期：2009年17-3] The general transcription factor TFIID is a large multi-subunit complex required for the transcription of most protein-encoding genes by RNA polymerase II. Taking advantage of a TFIIID preparation partially depleted in t... Structural Basis for Binding of RNA and Cofactor by a KsgA Methyltransferase [作者：Tu, C; Tropea, JE; Austin, BP; Court, DL; Waugh, DS; Ji, XH,期刊：Structure, 页码：374-385 , 文章类型： Article，,卷期：2009年17-3] Among methyltransferases, KsgA and the reaction it catalyzes are conserved throughout evolution. However, the specifics of substrate recognition by the enzyme remain unknown. Here we report structures of Aquifex aeolicus... Dynamic Dysfunction in Dihydrofolate Reductase Results from Antifolate Drug Binding: Modulation of Dynamics within a Structural State [作者：Mauldin, RV; Carroll, MJ; Lee, AL,期刊：Structure, 页码：386-394 , 文章类型： Article，,卷期：2009年17-3] The arduous task of rationally designing small-molecule enzyme inhibitors is complicated by the inherent flexibility of the protein scaffold. To gain insight into the changes in dynamics associated with small-molecule-ba... Rhomboid Protease Dynamics and Lipid Interactions [作者：Bondar, AN; del Val, C; White, SH,期刊：Structure, 页码：395-405 , 文章类型： Article，,卷期：2009年17-3] Intramembrane proteases, which cleave transmembrane (TM) helices, participate in numerous biological processes encompassing all branches of life. Several crystallographic structures of Escherichia coli GIpG rhomboid prot... Hybrid Structural Model of the Complete Human ESCRT-0 Complex [作者：Ren, XF; Kloer, DP; Kim, YC; Ghirlando, R; Saidi, LF; Hummer, G; Hurley, JH,期刊：Structure, 页码：406-416 , 文章类型： Article，,卷期：2009年17-3] The human Hrs and STAM proteins comprise the ESCRT-0 complex, which sorts ubiquitinated cell surface receptors to lysosomes for degradation. Here we report a model for the complete ESCRT-0 complex based on the crystal st... Core Structure of Amyloid Fibrils Formed by Residues 106-126 of the Human Prion Protein [作者：Walsh, P; Simonetti, K; Sharpel, S,期刊：Structure, 页码：417-426 , 文章类型： Article，,卷期：2009年17-3] Peptides comprising residues 106-126 of the human prion protein (PrP) exhibit many features of the full-length protein. PrP(106-126) induces apoptosis in neurons, forms fibrillar aggregates, and can mediate the conversio... Three-Dimensional Structure of AAA ATPase Vps4: Advancing Structural Insights into the Mechanisms of Endosomal Sorting and Enveloped Virus Budding [作者：Landsberg, MJ; Vajjhala, PR; Rothnagel, R; Munn, AL; Hankamer, B,期刊：Structure, 页码：427-437 , 文章类型： Article，,卷期：2009年17-3] Vps4 is a AAA ATPase that mediates endosomal membrane protein sorting. It is also a host factor hijacked by a diverse set of clinically important viruses, including HIV and Ebola, to facilitate viral budding. Here we pre... Structural and Biochemical Studies on Procaspase-8: New Insights on Initiator Caspase Activation [作者：Keller, N; Mares, J; Zerbe, O; Grutter, MG,期刊：Structure, 页码：438-448 , 文章类型： Article，,卷期：2009年17-3] Caspases are proteases with an active-site cysteine and aspartate specificity in their substrates. They are involved in apoptotic cell death and inflammation, and dysfunction of these enzymes is directly linked to a vari... Transport-Related Structures and Processes of the Nuclear Pore Complex Studied through Molecular Dynamics [作者：Miao, LL; Schulten, K,期刊：Structure, 页码：449-459 , 文章类型： Article，,卷期：2009年17-3] Nuclear pore complexes (NPCs) are selectively gated pathways between nucleoplasm and cytoplasm. Whereas small molecules can diffuse freely through NPCs, large molecules (>40 kD) can pass only when bound to transport rece... Cryo-Electron Tomography of Homophilic Adhesion Mediated by the Neural Cell Adhesion Molecule L1 [作者：He, YN; Jensen, GJ; Bjorkman, PJ,期刊：Structure, 页码：460-471 , 文章类型： Article，,卷期：2009年17-3] The neural cell adhesion molecule L1 participates in homophilic interactions important for axon guidance and neuronal development. The structural details of homophilic adhesion mediated by L1 and other immunoglobulin sup... Structure and Biological Function of the RNA Pyrophosphohydrolase BdRppH from Bdellovibrio bacteriovorus [作者：Messing, SAJ; Gabelli, SB; Liu, QS; Celesnik, H; Belasco, JG; Pineiro, SA; Amzel, LM,期刊：Structure, 页码：472-481 , 文章类型： Article，,卷期：2009年17-3] Until recently, the mechanism of mRNA decay in bacteria was thought to be different from that of eukaryotes. This paradigm changed with the discovery that RppH (ORF176/NudH/YgdP), an Escherichia coli enzyme that belongs ... Toward Structural Elucidation of the gamma-Secretase Complex [作者：Li, HL; Wolfe, MS; Selkoe, DJ,期刊：Structure, 页码：326-334 , 文章类型： Review，,卷期：2009年17-3] gamma-Secretase is an intramembrane protease complex that mediates the Notch signaling pathway and the production of amyloid beta-proteins. As such, this enzyme has emerged as an important target for development of novel...