- Structure of Epstein-Barr Virus Glycoprotein 42 Suggests a Mechanism for Triggering Receptor-Activated Virus Entry
[作者:Kirschner, AN; Sorem, J; Longnecker, R; Jardetzky, TS,期刊:Structure, 页码:223-233 , 文章类型: Article,,卷期:2009年17-2]
- Epstein-Barr virus requires glycoproteins gH/gL, gB, and gp42 to fuse its lipid envelope with B cells. Gp42 is a type II membrane protein consisting of a flexible N-terminal region, which binds gH/gL, and a C-terminal le...
- Gating Mechanism of the Influenza A M2 Channel Revealed by 1D and 2D IR Spectroscopies
[作者:Manor, J; Mukherjee, P; Lin, YS; Leonov, H; Skinner, JL; Zanni, MT; Arkin, IT,期刊:Structure, 页码:247-254 , 文章类型: Article,,卷期:2009年17-2]
- The pH-controlled M2 protein from influenza A is a critical component of the virus and serves as a target for the aminoadamantane antiflu agents that block its H+ channel activity. To better understand its H+ gating mech...
- Reconstruction of the P2X(2) Receptor Reveals a Vase-Shaped Structure with Lateral Tunnels above the Membrane
[作者:Mio, K; Ogura, T; Yamamoto, T; Hiroaki, Y; Fujiyoshi, Y; Kubo, Y; Sato, C,期刊:Structure, 页码:266-275 , 文章类型: Article,,卷期:2009年17-2]
- In response to the intercellular messenger ATP, P2X receptors transfer various sensory information, including pain. Here we have reconstructed the structure of the P2X(2) receptor at 15 A resolution from more than 90,000...
- Structural Basis of m(7)GpppG Binding to Poly(A)-Specific Ribonuclease
[作者:Wu, MS; Nilsson, P; Henriksson, N; Niedzwiecka, A; Lim, MK; Cheng, Z; Kokkoris, K; Virtanen, A; Song, HW,期刊:Structure, 页码:276-286 , 文章类型: Article,,卷期:2009年17-2]
- Poly(A)-specific ribonuclease (PARN) is a homodimeric, processive, and cap-interacting 3' exoribonuclease that efficiently degrades eukaryotic mRNA poly(A) tails. The crystal structure of a C-terminally truncated PARN in...
- Cryo-EM Structure of the Native GroEL-GroES Complex from Thermus thermophilus Encapsulating Substrate Inside the Cavity
[作者:Kanno, R; Koike-Takeshita, A; Yokoyama, K; Taguchi, H; Mitsuoka, K,期刊:Structure, 页码:287-293 , 文章类型: Article,,卷期:2009年17-2]
- The chaperonin GroEL interacts with various proteins, leading them to adopt their correct conformations with the aid of GroES and ATP. The actual mechanism is still being debated. In this study, by use of cryo-electron m...
- Structural Basis of Murein Peptide Specificity of a gamma-D-Glutamyl-L-Diamino Acid Endopeptidase
[作者:Xu, QP; Sudek, S; McMullan, D; Miller, MD; Geierstanger, B; Jones, DH; Krishna, SS; Spraggon, G; Bursalay, B; Abdubek, P; Acosta, C; Ambing, E; Astakhova, T; Axelrod, HL; Carlton, D; Caruthers, J; Chiu, HJ; Clayton, T; Deller, MC; Duan, L; Elias, Y; Elsliger, MA; Feuerhelm, J; Grzechnik, SK; Hale, J; Han, GW; Haugen, J; Jaroszewski, L; Jin, KK; Klock, HE; Knuth, MW; Kozbial, P; Kumar, A; Marciano, D; Morse, AT; Nigoghossian, E; Okach, L; Oommachen, S; Paulsen, J; Reyes, R; Rife, CL; Trout, CV; v,期刊:Structure, 页码:303-313 , 文章类型: Article,,卷期:2009年17-2]
- The crystal structures of two homologous endopeptidases from cyanobacteria Anabaena variabilis and Nostoc punctiforme were determined at 1.05 and 1.60 angstrom resolution, respectively, and contain a bacterial SH3-like d...
- For Structural Biology, Try Infrared Instead
[作者:Hamm, P,期刊:Structure, 页码:149-150 , 文章类型: Editorial Material,,卷期:2009年17-2]
- 1D and 2D-IR spectroscopy was used to resolve the structural transition that is responsible for the gating mechanism of the influenza A M2 channel (Manor et al., 2009). This report constitutes a milestone in the developm...
- Outcome of a Workshop on Applications of Protein Models in Biomedical Research
[作者:Schwede, T; Sali, A; Honig, B; Levitt, M; Berman, HM; Jones, D; Brenner, SE; Burley, SK; Das, R; Dokholyan, NV; Dunbrack, RL; Fidelis, K; Fiser, A; Godzik, A; Huang, YJ; Humblet, C; Jacobson, MP; Joachimiak, A; Krystek, SR; Kortemme, T; Kryshtafovych, A; Montelione, GT; Moult, J; Murray, D; Sanchez, R; Sosnick, TR; Standley, DM; Stouch, T; Vajda, S; Vasquez, M; Westbrook, JD; Wilson, IA,期刊:Structure, 页码:151-159 , 文章类型: Editorial Material,,卷期:2009年17-2]
- We describe the proceedings and conclusions from the "Workshop on Applications of Protein Models in Biomedical Research" (the Workshop) that was held at the University of California, San Francisco on 11 and 12 July, 2008...
- The Nucleosome Family: Dynamic and Growing
[作者:Zlatanova, J; Bishop, TC; Victor, JM; Jackson, V; van Holde, K,期刊:Structure, 页码:160-171 , 文章类型: Review,,卷期:2009年17-2]
- Ever since the discovery of the nucleosome in 1974, scientists have stumbled upon discrete particles in which DNA is wrapped around histone complexes of different stoichiometries: octasomes, hexasomes, tetrasomes, "split...
- Wheel of Life, Wheel of Death: A Mechanistic Insight into Signaling by STAND Proteins
[作者:Danot, O; Marquenet, E; Vidal-Ingigliardi, D; Richet, E,期刊:Structure, 页码:172-182 , 文章类型: Review,,卷期:2009年17-2]
- The signal transduction ATPases with numerous domains (STAND) represent a newly recognized class of widespread, sophisticated ATPases that are related to the AAA+ proteins and that function as signaling hubs. These prote...
- Conditional Restraints: Restraining the Free Atoms in ARP/wARP
[作者:Mooij, WTM; Cohen, SX; Joosten, K; Murshudov, GN; Perrakis, A,期刊:Structure, 页码:183-189 , 文章类型: Article,,卷期:2009年17-2]
- The automated building of a protein model into an electron density map remains a challenging problem. In the ARP/wARP approach, model building is facilitated by initially interpreting a density map with free atoms of unk...
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