个性化文献订阅>文章检索

文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共21条记录   Ubiquitin-mediated regulation of RhoGTPase signalling: IAPs and HACE1 enter the fray [作者：Orme, M; Bianchi, K; Meier, P,期刊：EMBO journal, 页码：1-2 , 文章类型： Article，,卷期：2012年31-1] Activation of members of the Rho-like family of guanosine triphosphatases GTPases (RhoGTPases) controls diverse physiological processes and is frequently found in cancer, contributing to tumour malignancy, cancer cell mi... The dark sides of capillary morphogenesis gene 2 [作者：Deuquet, J; Lausch, E; Superti-Furga, A; van der Goot, FG,期刊：EMBO journal, 页码：3-13 , 文章类型： Review，,卷期：2012年31-1] Capillary morphogenesis gene 2 (CMG2) is a type I membrane protein involved in the homeostasis of the extracellular matrix. While it shares interesting similarities with integrins, its exact molecular role is unknown. Th... IAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradation [作者：Oberoi, TK; Dogan, T; Hocking, JC; Scholz, RP; Mooz, J; Anderson, CL; Karreman, C; Heringdorf, DMZ; Schmidt, G; Ruonala, M; Namikawa, K; Harms, GS; Carpy, A; Macek, B; Koster, RW; Rajalingam, K,期刊：EMBO journal, 页码：14-28 , 文章类型： Article，,卷期：2012年31-1] Inhibitors of apoptosis proteins (IAPs) are a highly conserved class of multifunctional proteins. Rac1 is a well- studied Rho GTPase that controls numerous basic cellular processes. While the regulation of nucleotide bin... Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation [作者：Zhang, K; Rodriguez-Aznar, E; Yabuta, N; Owen, RJ; Mingot, JM; Nojima, H; Nieto, MA; Longmore, GD,期刊：EMBO journal, 页码：29-43 , 文章类型： Article，,卷期：2012年31-1] Snail1 is a central regulator of epithelial cell adhesion and movement in epithelial-to-mesenchymal transitions (EMTs) during embryo development; a process reactivated during cancer metastasis. While induction of Snail1 ... Distinct role of Mediator tail module in regulation of SAGA-dependent, TATA-containing genes in yeast [作者：Ansari, SA; Ganapathi, M; Benschop, JJ; Holstege, FCP; Wade, JT; Morse, RH,期刊：EMBO journal, 页码：44-57 , 文章类型： Article，,卷期：2012年31-1] The evolutionarily conserved Mediator complex is required for transcription of nearly all RNA Pol II-dependent promoters, with the tail module serving to recruit Mediator to active promoters in current models. However, t... MYST protein acetyltransferase activity requires active site lysine autoacetylation [作者：Yuan, H; Rossetto, D; Mellert, H; Dang, WW; Srinivasan, M; Johnson, J; Hodawadekar, S; Ding, EC; Speicher, K; Abshiru, N; Perry, R; Wu, J; Yang, C; Zheng, YG; Speicher, DW; Thibault, P; Verreault, A; Johnson, FB; Berger, SL; Sternglanz, R; McMahon, SB; Cote, J; Marmorstein, R,期刊：EMBO journal, 页码：58-70 , 文章类型： Article，,卷期：2012年31-1] The MYST protein lysine acetyltransferases are evolutionarily conserved throughout eukaryotes and acetylate proteins to regulate diverse biological processes including gene regulation, DNA repair, cell-cycle regulation, ... Cohesin acetyltransferase Esco2 is a cell viability factor and is required for cohesion in pericentric heterochromatin [作者：Whelan, G; Kreidl, E; Wutz, G; Egner, A; Peters, JM; Eichele, G,期刊：EMBO journal, 页码：71-82 , 文章类型： Article，,卷期：2012年31-1] Sister chromatid cohesion, mediated by cohesin and regulated by Sororin, is essential for chromosome segregation. In mammalian cells, cohesion establishment and Sororin recruitment to chromatin-bound cohesin depends on t... Nuclear retention of importin alpha coordinates cell fate through changes in gene expression [作者：Yasuda, Y; Miyamoto, Y; Yamashiro, T; Asally, M; Masui, A; Wong, C; Loveland, KL; Yoneda, Y,期刊：EMBO journal, 页码：83-94 , 文章类型： Article，,卷期：2012年31-1] Various cellular stresses including oxidative stress induce a collapse of the Ran gradient, which causes accumulation of importin alpha in the nucleus and a subsequent block of nuclear protein import. However, it is unkn... Physical and functional interaction between PML and TBX2 in the establishment of cellular senescence [作者：Martin, N; Benhamed, M; Nacerddine, K; Demarque, MD; van Lohuizen, M; Dejean, A; Bischof, O,期刊：EMBO journal, 页码：95-109 , 文章类型： Article，,卷期：2012年31-1] Cellular senescence acts as a potent barrier for tumour initiation and progression. Previous studies showed that the PML tumour suppressor promotes senescence, although the precise mechanisms remain to be elucidated. Com... SET8 promotes epithelial-mesenchymal transition and confers TWIST dual transcriptional activities [作者：Yang, F; Sun, LY; Li, Q; Han, X; Lei, LD; Zhang, H; Shang, YF,期刊：EMBO journal, 页码：110-123 , 文章类型： Article，,卷期：2012年31-1] SET8 is implicated in transcriptional regulation, heterochromatin formation, genomic stability, cell-cycle progression, and development. As such, it is predicted that SET8 might be involved in the development and progres... Nucleosomal organization of replication origins and meiotic recombination hotspots in fission yeast [作者：de Castro, E; Soriano, I; Marin, L; Serrano, R; Quintales, L; Antequera, F,期刊：EMBO journal, 页码：124-137 , 文章类型： Article，,卷期：2012年31-1] In Schizosaccharomyces pombe, DNA replication origins (ORIs) and meiotic recombination hotspots lack consensus sequences and show a bias towards mapping to large intergenic regions (IGRs). To explore whether this prefere... DNA-end capping by the budding yeast transcription factor and subtelomeric binding protein Tbf1 [作者：Ribaud, V; Ribeyre, C; Damay, P; Shore, D,期刊：EMBO journal, 页码：138-149 , 文章类型： Article，,卷期：2012年31-1] Telomere repeats in budding yeast are maintained at a constant average length and protected ('capped'), in part, by mechanisms involving the TG(1-3) repeat-binding protein Rap1. However, metazoan telomere repeats (T(2)AG... RNA/DNA hybrid binding affinity determines telomerase template-translocation efficiency [作者：Qi, XD; Xie, MY; Brown, AF; Bley, CJ; Podlevsky, JD; Chen, JJL,期刊：EMBO journal, 页码：150-161 , 文章类型： Article，,卷期：2012年31-1] Telomerase synthesizes telomeric DNA repeats onto chromosome termini from an intrinsic RNA template. The processive synthesis of DNA repeats relies on a unique, yet poorly understood, mechanism whereby the telomerase RNA... A syn-anti conformational difference allows SRSF2 to recognize guanines and cytosines equally well [作者：Daubner, GM; Clery, A; Jayne, S; Stevenin, J; Allain, FHT,期刊：EMBO journal, 页码：162-174 , 文章类型： Article，,卷期：2012年31-1] SRSF2 (SC35) is a key player in the regulation of alternative splicing events and binds degenerated RNA sequences with similar affinity in nanomolar range. We have determined the solution structure of the SRSF2 RRM bound... Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease [作者：Schmidt, V; Baum, K; Lao, A; Rateitschak, K; Schmitz, Y; Teichmann, A; Wiesner, B; Petersen, CM; Nykjaer, A; Wolf, J; Wolkenhauer, O; Willnow, TE,期刊：EMBO journal, 页码：187-200 , 文章类型： Article，,卷期：2012年31-1] The extent of proteolytic processing of the amyloid precursor protein (APP) into neurotoxic amyloid-beta (A beta) peptides is central to the pathology of Alzheimer's disease (AD). Accordingly, modifiers that increase A b... Expression of type I interferon by splenic macrophages suppresses adaptive immunity during sepsis [作者：Schwandt, T; Schumak, B; Gielen, GH; Jungerkes, F; Schmidbauer, P; Klocke, K; Staratschek-Jox, A; van Rooijen, N; Kraal, G; Ludwig-Portugall, I; Franken, L; Wehner, S; Kalff, JC; Weber, O; Kirschning, C; Coch, C; Kalinke, U; Wenzel, J; Kurts, C; Zawatzky, R; Holzmann, B; Layland, L; Schultze, JL; Burgdorf, S; den Haan, JMM; Knolle, PA; Limmer, A,期刊：EMBO journal, 页码：201-213 , 文章类型： Article，,卷期：2012年31-1] Early during Gram-negative sepsis, excessive release of pro-inflammatory cytokines can cause septic shock that is often followed by a state of immune paralysis characterized by the failure to mount adaptive immunity towa...