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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共23条记录   MYBPH, a transcriptional target of TTF-1, inhibits ROCK1, and reduces cell motility and metastasis [作者：Hosono, Y; Yamaguchi, T; Mizutani, E; Yanagisawa, K; Arima, C; Tomida, S; Shimada, Y; Hiraoka, M; Kato, S; Yokoi, K; Suzuki, M; Takahashi, T,期刊：EMBO journal, 页码：481-493 , 文章类型： Article，,卷期：2012年31-2] Cell migration driven by actomyosin filament assembly is a critical step in tumour invasion and metastasis. Herein, we report identification of myosin binding protein H (MYBPH) as a transcriptional target of TTF-1 (also ... Functional and structural studies of the nucleotide excision repair helicase XPD suggest a polarity for DNA translocation [作者：Kuper, J; Wolski, SC; Michels, G; Kisker, C,期刊：EMBO journal, 页码：494-502 , 文章类型： Article，,卷期：2012年31-2] The XPD protein is a vital subunit of the general transcription factor TFIIH which is not only involved in transcription but is also an essential component of the eukaryotic nucleotide excision DNA repair (NER) pathway. ... Regulation of translocation polarity by helicase domain 1 in SF2B helicases [作者：Pugh, RA; Wu, CG; Spies, M,期刊：EMBO journal, 页码：503-514 , 文章类型： Article，,卷期：2012年31-2] Structurally similar superfamily I (SF1) and II (SF2) helicases translocate on single-stranded DNA (ssDNA) with defined polarity either in the 5'-3' or in the 3'-5' direction. Both 5'-3' and 3'-5' translocating helicases... On epigenetics and epistasis: hybrids and their non-additive interactions [作者：Smith, LM; Weigel, D,期刊：EMBO journal, 页码：249-250 , 文章类型： Editorial Material，,卷期：2012年31-2] Hybrid seeds have been a key component of greatly increasing the yield of many important crops, foremost of maize. If the parents are properly chosen, non-additive interactions between diverged genomes can lead to strong... The nuclear receptor signalling scaffold: insights from full-length structures [作者：Nwachukwu, JC; Nettles, KW,期刊：EMBO journal, 页码：251-253 , 文章类型： Editorial Material，,卷期：2012年31-2] Nuclear receptors (NRs) can be conceptualized as highly dynamic scaffold proteins, where binding of ligand, DNA or transcriptional coregulator proteins can allosterically change the scaffold structure and direct changes ... Extracellular matrix players in metastatic niches [作者：Oskarsson, T; Massague, J,期刊：EMBO journal, 页码：254-256 , 文章类型： Editorial Material，,卷期：2012年31-2] Metastatic niches support the survival and fitness of disseminated tumour cells (DTCs) in otherwise inhospitable tissue environments. The components of metastatic niches have remained a matter of conjecture, but recent r... Extraordinary transgressive phenotypes of hybrid tomato are influenced by epigenetics and small silencing RNAs [作者：Shivaprasad, PV; Dunn, RM; Santos, BACM; Bassett, A; Baulcombe, DC,期刊：EMBO journal, 页码：257-266 , 文章类型： Article，,卷期：2012年31-2] Hybrid organisms may fail to develop, be sterile or they may be more vigorous than either of the parents. Examples of hybrid vigour or hybrid necrosis in the F1 are often not inherited stably in subsequent generations if... Cyclophilin 40 facilitates HSP90-mediated RISC assembly in plants [作者：Iki, T; Yoshikawa, M; Meshi, T; Ishikawa, M,期刊：EMBO journal, 页码：267-278 , 文章类型： Article，,卷期：2012年31-2] Posttranscriptional gene silencing is mediated by RNA-induced silencing complexes (RISCs) that contain AGO proteins and single-stranded small RNAs. The assembly of plant AGO1-containing RISCs depends on the molecular cha... The structural basis of Edc3- and Scd6-mediated activation of the Dcp1:Dcp2 mRNA decapping complex [作者：Fromm, SA; Truffault, V; Kamenz, J; Braun, JE; Hoffmann, NA; Izaurralde, E; Sprangers, R,期刊：EMBO journal, 页码：279-290 , 文章类型： Article，,卷期：2012年31-2] The Dcp1:Dcp2 decapping complex catalyses the removal of the mRNA 5' cap structure. Activator proteins, including Edc3 (enhancer of decapping 3), modulate its activity. Here, we solved the structure of the yeast Edc3 LSm... Structure of the full human RXR/VDR nuclear receptor heterodimer complex with its DR3 target DNA [作者：Orlov, I; Rochel, N; Moras, D; Klaholz, BP,期刊：EMBO journal, 页码：291-300 , 文章类型： Article，,卷期：2012年31-2] Transcription regulation by steroid hormones and other metabolites is mediated by nuclear receptors (NRs) such as the vitamin D and retinoid X receptors (VDR and RXR). Here, we present the cryo electron microscopy (cryo-... Signal-dependent incorporation of MyoD-BAF60c into Brg1-based SWI/SNF chromatin-remodelling complex [作者：Forcales, SV; Albini, S; Giordani, L; Malecova, B; Cignolo, L; Chernov, A; Coutinho, P; Saccone, V; Consalvi, S; Williams, R; Wang, KP; Wu, ZG; Baranovskaya, S; Miller, A; Dilworth, FJ; Puri, PL,期刊：EMBO journal, 页码：301-316 , 文章类型： Article，,卷期：2012年31-2] Tissue-specific transcriptional activators initiate differentiation towards specialized cell types by inducing chromatin modifications permissive for transcription at target loci, through the recruitment of SWItch/Sucros... An interspecies analysis reveals a key role for unmethylated CpG dinucleotides in vertebrate Polycomb complex recruitment [作者：Lynch, MD; Smith, AJH; De Gobbi, M; Flenley, M; Hughes, JR; Vernimmen, D; Ayyub, H; Sharpe, JA; Sloane-Stanley, JA; Sutherland, L; Meek, S; Burdon, T; Gibbons, RJ; Garrick, D; Higgs, DR,期刊：EMBO journal, 页码：317-329 , 文章类型： Article，,卷期：2012年31-2] The role of DNA sequence in determining chromatin state is incompletely understood. We have previously demonstrated that large chromosomal segments from human cells recapitulate their native chromatin state in mouse cell... Human tRNA genes function as chromatin insulators [作者：Raab, JR; Chiu, J; Zhu, JC; Katzman, S; Kurukuti, S; Wade, PA; Haussler, D; Kamakaka, RT,期刊：EMBO journal, 页码：330-350 , 文章类型： Article，,卷期：2012年31-2] Insulators help separate active chromatin domains from silenced ones. In yeast, gene promoters act as insulators to block the spread of Sir and HP1 mediated silencing while in metazoans most insulators are multipartite a... FOG-1 and GATA-1 act sequentially to specify definitive megakaryocytic and erythroid progenitors [作者：Mancini, E; Sanjuan-Pla, A; Luciani, L; Moore, S; Grover, A; Zay, A; Rasmussen, KD; Luc, S; Bilbao, D; O'Carroll, D; Jacobsen, SE; Nerlov, C,期刊：EMBO journal, 页码：351-365 , 文章类型： Article，,卷期：2012年31-2] The transcription factors that control lineage specification of haematopoietic stem cells (HSCs) have been well described for the myeloid and lymphoid lineages, whereas transcriptional control of erythroid (E) and megaka... Coreceptor gene imprinting governs thymocyte lineage fate [作者：Adoro, S; McCaughtry, T; Erman, B; Alag, A; Van Laethem, F; Park, JH; Tai, XG; Kimura, M; Wang, L; Grinberg, A; Kubo, M; Bosselut, R; Love, P; Singer, A,期刊：EMBO journal, 页码：366-377 , 文章类型： Article，,卷期：2012年31-2] Immature thymocytes are bipotential cells that are signalled during positive selection to become either helper- or cytotoxic-lineage T cells. By tracking expression of lineage determining transcription factors during pos... Synthetic biology approach to reconstituting the ubiquitylation cascade in bacteria [作者：Keren-Kaplan, T; Attali, I; Motamedchaboki, K; Davis, BA; Tanner, N; Reshef, Y; Laudon, E; Kolot, M; Levin-Kravets, O; Kleifeld, O; Glickman, M; Horazdovsky, BF; Wolf, DA; Prag, G,期刊：EMBO journal, 页码：378-390 , 文章类型： Article，,卷期：2012年31-2] Covalent modification of proteins with ubiquitin (Ub) is widely implicated in the control of protein function and fate. Over 100 deubiquitylating enzymes rapidly reverse this modification, posing challenges to the bioche...