个性化文献订阅>文章检索

文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共23条记录   Tail-anchor targeting by a Get3 tetramer: the structure of an archaeal homologue [作者：Suloway, CJM; Rome, ME; Clemons, WM,期刊：EMBO journal, 页码：707-719 , 文章类型： Article，,卷期：2012年31-3] Efficient delivery of membrane proteins is a critical cellular process. The recently elucidated GET (Guided Entry of TA proteins) pathway is responsible for the targeted delivery of tail-anchored (TA) membrane proteins t... Symmetry-free cryo-EM structures of the chaperonin TRiC along its ATPase-driven conformational cycle [作者：Cong, Y; Schroder, GF; Meyer, AS; Jakana, J; Ma, BX; Dougherty, MT; Schmid, MF; Reissmann, S; Levitt, M; Ludtke, SL; Frydman, J; Chiu, W,期刊：EMBO journal, 页码：720-730 , 文章类型： Article，,卷期：2012年31-3] The eukaryotic group II chaperonin TRiC/CCT is a 16-subunit complex with eight distinct but similar subunits arranged in two stacked rings. Substrate folding inside the central chamber is triggered by ATP hydrolysis. We ... Mechanism of nucleotide sensing in group II chaperonins [作者：Pereira, JH; Ralston, CY; Douglas, NR; Kumar, R; Lopez, T; McAndrew, RP; Knee, KM; King, JA; Frydman, J; Adams, PD,期刊：EMBO journal, 页码：731-740 , 文章类型： Article，,卷期：2012年31-3] Group II chaperonins mediate protein folding in an ATP-dependent manner in eukaryotes and archaea. The binding of ATP and subsequent hydrolysis promotes the closure of the multi-subunit rings where protein folding occurs... A viral deubiquitylating enzyme targets viral RNA-dependent RNA polymerase and affects viral infectivity [作者：Chenon, M; Camborde, L; Cheminant, S; Jupin, I,期刊：EMBO journal, 页码：741-753 , 文章类型： Article，,卷期：2012年31-3] Selective protein degradation via the ubiquitin-proteasome system (UPS) plays an essential role in many major cellular processes, including host-pathogen interactions. We previously reported that the tightly regulated vi... Monoamines and neuropeptides interact to inhibit aversive behaviour in Caenorhabditis elegans [作者：Mills, H; Wragg, R; Hapiak, V; Castelletto, M; Zahratka, J; Harris, G; Summers, P; Korchnak, A; Law, W; Bamber, B; Komuniecki, R,期刊：EMBO journal, 页码：667-678 , 文章类型： Article，,卷期：2012年31-3] Pain modulation is complex, but noradrenergic signalling promotes anti-nociception, with alpha(2)-adrenergic agonists used clinically. To better understand the noradrenergic/peptidergic modulation of nociception, we exam... Optimal functional levels of activation-induced deaminase specifically require the Hsp40 DnaJa1 [作者：Orthwein, A; Zahn, A; Methot, SP; Godin, D; Conticello, SG; Terada, K; Di Noia, JM,期刊：EMBO journal, 页码：679-691 , 文章类型： Article，,卷期：2012年31-3] The enzyme activation-induced deaminase (AID) deaminates deoxycytidine at the immunoglobulin genes, thereby initiating antibody affinity maturation and isotype class switching during immune responses. In contrast, off-ta... The NF-kappa B1 transcription factor prevents the intrathymic development of CD8 T cells with memory properties [作者：Gugasyan, R; Horat, E; Kinkel, SA; Ross, F; Grigoriadis, G; Gray, D; O'Keeffe, M; Berzins, SP; Belz, GT; Grumont, RJ; Banerjee, A; Strasser, A; Godfrey, DI; Tsichlis, PN; Gerondakis, S,期刊：EMBO journal, 页码：692-706 , 文章类型： Article，,卷期：2012年31-3] The role of specific members of the NF-kappa B family of transcription factors in CD8 T-cell selection and development is largely unknown. Here, we show that mice lacking NF-kappa B1 develop a unique population of conven... ACBD3-mediated recruitment of PI4KB to picornavirus RNA replication sites [作者：Sasaki, J; Ishikawa, K; Arita, M; Taniguchi, K,期刊：EMBO journal, 页码：754-766 , 文章类型： Article，,卷期：2012年31-3] Phosphatidylinositol 4-kinase III beta (PI4KB) is a host factor required for genome RNA replication of enteroviruses, small non-enveloped viruses belonging to the family Picornaviridae. Here, we demonstrated that PI4KB i... Structural insights into the neutralization mechanism of a higher primate antibody against dengue virus [作者：Cockburn, JJB; Sanchez, MEN; Goncalvez, AP; Zaitseva, E; Stura, EA; Kikuti, CM; Duquerroy, S; Dussart, P; Chernomordik, LV; Lai, CJ; Rey, FA,期刊：EMBO journal, 页码：767-779 , 文章类型： Article，,卷期：2012年31-3] The four serotypes of dengue virus (DENV-1 to -4) cause the most important emerging viral disease. Protein E, the principal viral envelope glycoprotein, mediates fusion of the viral and endosomal membranes during virus e... RNA driving the epigenetic bus [作者：Mattick, JS,期刊：EMBO journal, 页码：515-516 , 文章类型： Editorial Material，,卷期：2012年31-3] For many years, it has been assumed that mammalian development is primarily controlled by transcription factors, but recent studies, including that reported by Ng et al (2012) in this issue, indicate that there is an add... Rac1 gets fattier [作者：Tsai, FD; Philips, MR,期刊：EMBO journal, 页码：517-518 , 文章类型： Editorial Material，,卷期：2012年31-3] Since its description more than two decades ago as a substrate for botulinum C3 exoenzyme (Didsbury et al, 1989), Rac1 has been one of the most studied small GTPases of the Ras superfamily. Interest in Rac1 exploded in 1... A structural road map to unveil basal body composition and assembly [作者：Jana, SC; Machado, P; Bettencourt-Dias, M,期刊：EMBO journal, 页码：519-521 , 文章类型： Editorial Material，,卷期：2012年31-3] The Basal Body (BB) acts as the template for the axoneme, the microtubule-based structure of cilia and flagella. Although several proteins were recently implicated in both centriole and BB assembly and function, their mo... Human long non-coding RNAs promote pluripotency and neuronal differentiation by association with chromatin modifiers and transcription factors [作者：Ng, SY; Johnson, R; Stanton, LW,期刊：EMBO journal, 页码：522-533 , 文章类型： Article，,卷期：2012年31-3] Long non-coding RNAs (lncRNAs) are a numerous class of newly discovered genes in the human genome, which have been proposed to be key regulators of biological processes, including stem cell pluripotency and neurogenesis.... A palmitoylation switch mechanism regulates Rac1 function and membrane organization [作者：Navarro-Lerida, I; Sanchez-Perales, S; Calvo, M; Rentero, C; Zheng, Y; Enrich, C; Del Pozo, MA,期刊：EMBO journal, 页码：534-551 , 文章类型： Article，,卷期：2012年31-3] The small GTPase Rac1 plays important roles in many processes, including cytoskeletal reorganization, cell migration, cell-cycle progression and gene expression. The initiation of Rac1 signalling requires at least two me... Three-dimensional structure of basal body triplet revealed by electron cryo-tomography [作者：Li, S; Fernandez, JJ; Marshall, WF; Agard, DA,期刊：EMBO journal, 页码：552-562 , 文章类型： Article，,卷期：2012年31-3] Basal bodies and centrioles play central roles in microtubule (MT)-organizing centres within many eukaryotes. They share a barrel-shaped cylindrical structure composed of nine MT triplet blades. Here, we report the struc... H2O2 stress-specific regulation of S. pombe MAPK Sty1 by mitochondrial protein phosphatase Ptc4 [作者：Di, YJ; Holmes, EJ; Butt, A; Dawson, K; Mironov, A; Kotiadis, VN; Gourlay, CW; Jones, N; Wilkinson, CRM,期刊：EMBO journal, 页码：563-575 , 文章类型： Article，,卷期：2012年31-3] In fission yeast, the stress-activated MAP kinase, Sty1, is activated via phosphorylation upon exposure to stress and orchestrates an appropriate response. Its activity is attenuated by either serine/threonine PP2C or ty...