个性化文献订阅>文章检索

文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共23条记录   Metaplasticity gated through differential regulation of GluN2A versus GluN2B receptors by Src family kinases [作者：Yang, K; Trepanier, C; Sidhu, B; Xie, YF; Li, HB; Lei, G; Salter, MW; Orser, BA; Nakazawa, T; Yamamoto, T; Jackson, MF; MacDonald, JF,期刊：EMBO journal, 页码：805-816 , 文章类型： Article，,卷期：2012年31-4] Metaplasticity is a higher form of synaptic plasticity that is essential for learning and memory, but its molecular mechanisms remain poorly understood. Here, we report that metaplasticity of transmission at CA1 synapses... Pten coordinates retinal neurogenesis by regulating Notch signalling [作者：Jo, HS; Kang, KH; Joe, CO; Kim, JW,期刊：EMBO journal, 页码：817-828 , 文章类型： Article，,卷期：2012年31-4] Development of nervous tissue is a coordinated process of neural progenitor cell (NPC) proliferation and neuronal differentiation. Intracellular signalling events that regulate the balance between NPC proliferation and n... CSP alpha knockout causes neurodegeneration by impairing SNAP-25 function [作者：Sharma, M; Burre, J; Bronk, P; Zhang, YS; Xu, W; Sudhof, TC,期刊：EMBO journal, 页码：829-841 , 文章类型： Article，,卷期：2012年31-4] At a synapse, the synaptic vesicle protein cysteine-string protein-alpha (CSP alpha) functions as a co-chaperone for the SNARE protein SNAP-25. Knockout (KO) of CSP alpha causes fulminant neurodegeneration that is rescue... Identification and characterization of a resident vascular stem/progenitor cell population in preexisting blood vessels [作者：Naito, H; Kidoya, H; Sakimoto, S; Wakabayashi, T; Takakura, N,期刊：EMBO journal, 页码：842-855 , 文章类型： Article，,卷期：2012年31-4] Vasculogenesis, the in-situ assembly of angioblast or endothelial progenitor cells (EPCs), may persist into adult life, contributing to new blood vessel formation. However, EPCs are scattered throughout newly developed b... Lymphatics thrive on stress: mechanical force in lymphatic development [作者：Schwartz, MA; Simons, M,期刊：EMBO journal, 页码：781-782 , 文章类型： Editorial Material，,卷期：2012年31-4] The arteries, veins, capillaries and lymphatic vessels that comprise the vertebrate vascular system function to transport blood and lymphatic fluid to and from the tissues. It is therefore unsurprising that development, ... Directional gating of synaptic plasticity by GPCRs and their distinct downstream signalling pathways [作者：Gong, B; Wang, YT,期刊：EMBO journal, 页码：783-785 , 文章类型： Editorial Material，,卷期：2012年31-4] Synaptic plasticity, the activity-dependent modification of synaptic strength, plays a fundamental role in learning and memory as well as in developmental maturation of neuronal circuitry. However, how synaptic plasticit... A microRNA that limits metastatic colonisation and endothelial recruitment [作者：Khew-Goodall, Y; Goodall, GJ,期刊：EMBO journal, 页码：786-787 , 文章类型： Editorial Material，,卷期：2012年31-4] For a cancer to metastasise, it must overcome the physiological mechanisms that normally protect against the dissemination of cells and their lodgement and growth at remote sites. The mechanisms by which invading cancer ... Mechanoinduction of lymph vessel expansion [作者：Planas-Paz, L; Strilic, B; Goedecke, A; Breier, G; Fassler, R; Lammert, E,期刊：EMBO journal, 页码：788-804 , 文章类型： Article，,卷期：2012年31-4] In the mammalian embryo, few mechanical signals have been identified to influence organ development and function. Here, we report that an increase in the volume of interstitial or extracellular fluid mechanically induces... Dysregulation of DNA polymerase kappa recruitment to replication forks results in genomic instability [作者：Jones, MJK; Colnaghi, L; Huang, TT,期刊：EMBO journal, 页码：908-918 , 文章类型： Article，,卷期：2012年31-4] Translesion synthesis polymerases (TLS Pols) are required to tolerate DNA lesions that would otherwise cause replication arrest and cell death. Aberrant expression of these specialized Pols may be responsible for increas... DNA binding to proteolytically activated TLR9 is sequence-independent and enhanced by DNA curvature [作者：Li, Y; Berke, IC; Modis, Y,期刊：EMBO journal, 页码：919-931 , 文章类型： Article，,卷期：2012年31-4] Toll-like receptor 9 (TLR9) recognizes microbial DNA in endolysosomal compartments. The ectodomain of TLR9 must be proteolytically cleaved by endosomal proteases to produce the active receptor capable of inducing an inna... Phagosomal proteolysis in dendritic cells is modulated by NADPH oxidase in a pH-independent manner [作者：Rybicka, JM; Balce, DR; Chaudhuri, S; Allan, ERO; Yates, RM,期刊：EMBO journal, 页码：932-944 , 文章类型： Article，,卷期：2012年31-4] The level of proteolysis within phagosomes of dendritic cells (DCs) is thought to be tightly regulated, as it directly impacts the cell's efficiency to process antigen. Activity of the antimicrobial effector NADPH oxidas... VprBP binds full-length RAG1 and is required for B-cell development and V(D)J recombination fidelity [作者：Kassmeier, MD; Mondal, K; Palmer, VL; Raval, P; Kumar, S; Perry, GA; Anderson, DK; Ciborowski, P; Jackson, S; Xiong, Y; Swanson, PC,期刊：EMBO journal, 页码：945-958 , 文章类型： Article，,卷期：2012年31-4] The N-terminus of full-length RAG1, though dispensable for RAG1/2 cleavage activity, is required for efficient V( D) J recombination. This region supports RING E3 ubiquitin ligase activity in vitro, but whether full-leng... A novel GRK2/HDAC6 interaction modulates cell spreading and motility [作者：Lafarga, V; Aymerich, I; Tapia, O; Mayor, F; Penela, P,期刊：EMBO journal, 页码：856-869 , 文章类型： Article，,卷期：2012年31-4] Cell motility and adhesion involves dynamic microtubule (MT) acetylation/deacetylation, a process regulated by enzymes as HDAC6, a major cytoplasmic alpha-tubulin deacetylase. We identify G protein-coupled receptor kinas... The tudor domain protein Kumo is required to assemble the nuage and to generate germline piRNAs in Drosophila [作者：Anand, A; Kai, T,期刊：EMBO journal, 页码：870-882 , 文章类型： Article，,卷期：2012年31-4] In Drosophila ovaries, distinct Piwi-interacting RNA (piRNA) pathways defend against transposons in somatic and germline cells. Germline piRNAs predominantly arise from bidirectional clusters and are amplified by the pin... dNTP pools determine fork progression and origin usage under replication stress [作者：Poli, J; Tsaponina, O; Crabbe, L; Keszthelyi, A; Pantesco, V; Chabes, A; Lengronne, A; Pasero, P,期刊：EMBO journal, 页码：883-894 , 文章类型： Article，,卷期：2012年31-4] Intracellular deoxyribonucleoside triphosphate (dNTP) pools must be tightly regulated to preserve genome integrity. Indeed, alterations in dNTP pools are associated with increased mutagenesis, genomic instability and tum... Endogenous DNA replication stress results in expansion of dNTP pools and a mutator phenotype [作者：Davidson, MB; Katou, Y; Keszthelyi, A; Sing, TL; Xia, T; Ou, JW; Vaisica, JA; Thevakumaran, N; Marjavaara, L; Myers, CL; Chabes, A; Shirahige, K; Brown, GW,期刊：EMBO journal, 页码：895-907 , 文章类型： Article，,卷期：2012年31-4] The integrity of the genome depends on diverse pathways that regulate DNA metabolism. Defects in these pathways result in genome instability, a hallmark of cancer. Deletion of ELG1 in budding yeast, when combined with hy...