- Ready, STAT, go: transcription factors on the move
[作者：Di Liberto, V; Cavalli, V,期刊：EMBO journal, 页码：1331-1333 , 文章类型： Editorial Material，,卷期：2012年31-6]
- In this issue of The EMBO Journal, Ben-Yaakov et al (2012) explore the contribution of transcription factors (TFs) in directly communicating information about injury between the axon and the nucleus. They show that multi...
- Axonal transcription factors signal retrogradely in lesioned peripheral nerve
[作者：Ben-Yaakov, K; Dagan, SY; Segal-Ruder, Y; Shalem, O; Vuppalanchi, D; Willis, DE; Yudin, D; Rishal, I; Rother, F; Bader, M; Blesch, A; Pilpel, Y; Twiss, JL; Fainzilber, M,期刊：EMBO journal, 页码：1350-1363 , 文章类型： Article，,卷期：2012年31-6]
- Retrograde axonal injury signalling stimulates cell body responses in lesioned peripheral neurons. The involvement of importins in retrograde transport suggests that transcription factors (TFs) might be directly involved...
- A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis
[作者：Arac, D; Boucard, AA; Bolliger, MF; Nguyen, J; Soltis, SM; Sudhof, TC; Brunger, AT,期刊：EMBO journal, 页码：1364-1378 , 文章类型： Article，,卷期：2012年31-6]
- The G protein-coupled receptor (GPCR) Proteolysis Site (GPS) of cell-adhesion GPCRs and polycystic kidney disease (PKD) proteins constitutes a highly conserved autoproteolysis sequence, but its catalytic mechanism remain...
- Hypoxia regulates glutamate receptor trafficking through an HIF-independent mechanism
[作者：Park, EC; Ghose, P; Shao, ZY; Ye, Q; Kang, LJ; Xu, XZS; Powell-Coffman, JA; Rongo, C,期刊：EMBO journal, 页码：1379-1393 , 文章类型： Article，,卷期：2012年31-6]
- Oxygen influences behaviour in many organisms, with low levels (hypoxia) having devastating consequences for neuron survival. How neurons respond physiologically to counter the effects of hypoxia is not fully understood....
- O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release
[作者：Pathak, S; Borodkin, VS; Albarbarawi, O; Campbell, DG; Ibrahim, A; van Aalten, DMF,期刊：EMBO journal, 页码：1394-1404 , 文章类型： Article，,卷期：2012年31-6]
- Transforming growth factor (TGF)-beta-activated kinase 1 (TAK1) is a key serine/threonine protein kinase that mediates signals transduced by pro-inflammatory cytokines such as transforming growth factor-beta, tumour necr...
- DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients
[作者：Volkmar, M; Dedeurwaerder, S; Cunha, DA; Ndlovu, MN; Defrance, M; Deplus, R; Calonne, E; Volkmar, U; Igoillo-Esteve, M; Naamane, N; Del Guerra, S; Masini, M; Bugliani, M; Marchetti, P; Cnop, M; Eizirik, DL; Fuks, F,期刊：EMBO journal, 页码：1405-1426 , 文章类型： Article，,卷期：2012年31-6]
- In addition to genetic predisposition, environmental and lifestyle factors contribute to the pathogenesis of type 2 diabetes (T2D). Epigenetic changes may provide the link for translating environmental exposures into pat...
- PML regulates PER2 nuclear localization and circadian function
[作者：Miki, T; Xu, ZX; Chen-Goodspeed, M; Liu, MG; Van Oort-Jansen, A; Rea, MA; Zhao, ZY; Lee, CC; Chang, KS,期刊：EMBO journal, 页码：1427-1439 , 文章类型： Article，,卷期：2012年31-6]
- Studies have suggested that the clock regulator PER2 is a tumour suppressor. A cancer network involving PER2 raises the possibility that some tumour suppressors are directly involved in the mammalian clock. Here, we show...
- A role for alpha-adducin (ADD-1) in nematode and human memory
[作者：Vukojevic, V; Gschwind, L; Vogler, C; Demougin, P; de Quervain, DJF; Papassotiropoulos, A; Stetak, A,期刊：EMBO journal, 页码：1453-1466 , 文章类型： Article，,卷期：2012年31-6]
- Identifying molecular mechanisms that underlie learning and memory is one of the major challenges in neuroscience. Taken the advantages of the nematode Caenorhabditis elegans, we investigated alpha-adducin (add-1) in ave...
- Xenopus Shugoshin 2 regulates the spindle assembly pathway mediated by the chromosomal passenger complex
[作者：Rivera, T; Ghenoiu, C; Rodriguez-Corsino, M; Mochida, S; Funabiki, H; Losada, A,期刊：EMBO journal, 页码：1467-1479 , 文章类型： Article，,卷期：2012年31-6]
- Shugoshins (Sgo) are conserved proteins that act as protectors of centromeric cohesion and as sensors of tension for the machinery that eliminates improper kinetochore-microtubule attachments. Most vertebrates contain tw...
- Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes
[作者：Magyar, Z; Horvath, B; Khan, S; Mohammed, B; Henriques, R; De Veylder, L; Bako, L; Scheres, B; Bogre, L,期刊：EMBO journal, 页码：1480-1493 , 文章类型： Article，,卷期：2012年31-6]
- Post-embryonic growth in plants depends on the continuous supply of undifferentiated cells within meristems. Proliferating cells maintain their competence for division by active repression of differentiation and the asso...
- Myeloid translocation gene 16 is required for maintenance of haematopoietic stem cell quiescence
[作者：Fischer, MA; Moreno-Miralles, I; Hunt, A; Chyla, BJ; Hiebert, SW,期刊：EMBO journal, 页码：1494-1505 , 文章类型： Article，,卷期：2012年31-6]
- The t(8;21) and t(16;21) that are associated with acute myeloid leukaemia disrupt two closely related genes termed Myeloid Translocation Genes 8 (MTG8) and 16 (MTG16), respectively. Many of the transcription factors that...
- The architecture of functional modules in the Hsp90 co-chaperone Sti1/Hop
[作者：Schmid, AB; Lagleder, S; Grawert, MA; Rohl, A; Hagn, F; Wandinger, SK; Cox, MB; Demmer, O; Richter, K; Groll, M; Kessler, H; Buchner, J,期刊：EMBO journal, 页码：1506-1517 , 文章类型： Article，,卷期：2012年31-6]
- Sti1/Hop is a modular protein required for the transfer of client proteins from the Hsp70 to the Hsp90 chaperone system in eukaryotes. It binds Hsp70 and Hsp90 simultaneously via TPR (tetratricopeptide repeat) domains. S...
- Dynamics of the regulation of Hsp90 by the co-chaperone Sti1
[作者：Lee, CT; Graf, C; Mayer, FJ; Richter, SM; Mayer, MP,期刊：EMBO journal, 页码：1518-1528 , 文章类型： Article，,卷期：2012年31-6]
- In eukaryotic cells, Hsp90 chaperones assist late folding steps of many regulatory protein clients by a complex ATPase cycle. Binding of clients to Hsp90 requires prior interaction with Hsp70 and a transfer reaction that...
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