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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共18条记录   NLK positively regulates Wnt/beta-catenin signalling by phosphorylating LEF1 in neural progenitor cells [作者：Ota, S; Ishitani, S; Shimizu, N; Matsumoto, K; Itoh, M; Ishitani, T,期刊：EMBO journal, 页码：1904-1915 , 文章类型： Article，,卷期：2012年31-8] Nemo-like kinase (NLK/Nlk) is an evolutionarily conserved protein kinase involved in Wnt/beta-catenin signalling. However, the roles of NLK in Wnt/beta-catenin signalling in vertebrates remain unclear. Here, we show that... Nutrient/TOR-dependent regulation of RNA polymerase III controls tissue and organismal growth in Drosophila [作者：Marshall, L; Rideout, EJ; Grewal, SS,期刊：EMBO journal, 页码：1916-1930 , 文章类型： Article，,卷期：2012年31-8] The nutrient/target-of-rapamycin (TOR) pathway has emerged as a key regulator of tissue and organismal growth in metazoans. The signalling components of the nutrient/TOR pathway are well defined; however, the downstream ... Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC [作者：McKnight, NC; Jefferies, HBJ; Alemu, EA; Saunders, RE; Howell, M; Johansen, T; Tooze, SA,期刊：EMBO journal, 页码：1931-1946 , 文章类型： Article，,卷期：2012年31-8] Autophagy is a catabolic process by which cytoplasmic components are sequestered and transported by autophagosomes to lysosomes for degradation, enabling recycling of these components and providing cells with amino acids... Ebola virus entry requires the host-programmed recognition of an intracellular receptor [作者：Miller, EH; Obernosterer, G; Raaben, M; Herbert, AS; Deffieu, MS; Krishnan, A; Ndungo, E; Sandesara, RG; Carette, JE; Kuehne, AI; Ruthel, G; Pfeffer, SR; Dye, JM; Whelan, SP; Brummelkamp, TR; Chandran, K,期刊：EMBO journal, 页码：1947-1960 , 文章类型： Article，,卷期：2012年31-8] Ebola and Marburg filoviruses cause deadly outbreaks of haemorrhagic fever. Despite considerable efforts, no essential cellular receptors for filovirus entry have been identified. We showed previously that Niemann-Pick C... Multiple factors dictate target selection by Hfq-binding small RNAs [作者：Beisel, CL; Updegrove, TB; Janson, B; Storz, G,期刊：EMBO journal, 页码：1961-1974 , 文章类型： Article，,卷期：2012年31-8] Hfq-binding small RNAs (sRNAs) in bacteria modulate the stability and translational efficiency of target mRNAs through limited base-pairing interactions. While these sRNAs are known to regulate numerous mRNAs as part of ... Dehydration stress activates Arabidopsis MPK6 to signal DCP1 phosphorylation [作者：Xu, J; Chua, NH,期刊：EMBO journal, 页码：1975-1984 , 文章类型： Article，,卷期：2012年31-8] Eukaryotic mRNA decapping proteins are essential for normal turnover of mRNA. Yet, the mechanism of bulk mRNA turnover during stress responses and its importance to stress tolerance are poorly understood. Here, we showed... A novel miR-155/miR-143 cascade controls glycolysis by regulating hexokinase 2 in breast cancer cells [作者：Jiang, S; Zhang, LF; Zhang, HW; Hu, S; Lu, MH; Liang, S; Li, B; Li, Y; Li, DS; Wang, ED; Liu, MF,期刊：EMBO journal, 页码：1985-1998 , 文章类型： Article，,卷期：2012年31-8] Cancer cells preferentially metabolize glucose through aerobic glycolysis. This phenomenon, known as the Warburg effect, is an anomalous characteristic of glucose metabolism in cancer cells. Chronic inflammation is a key... Claudin-14 regulates renal Ca++ transport in response to CaSR signalling via a novel microRNA pathway [作者：Gong, YF; Renigunta, V; Himmerkus, N; Zhang, JQ; Renigunta, A; Bleich, M; Hou, JH,期刊：EMBO journal, 页码：1999-2012 , 文章类型： Article，,卷期：2012年31-8] The paracellular claudin channel of the thick ascending limb (TAL) of Henle is critical for Ca++ reabsorption in the kidney. Genome-wide association studies (GWASs) have identified claudin-14 associated with hypercalciur... Codanin-1, mutated in the anaemic disease CDAI, regulates Asf1 function in S-phase histone supply [作者：Ask, K; Jasencakova, Z; Menard, P; Feng, YP; Almouzni, G; Groth, A,期刊：EMBO journal, 页码：2013-2023 , 文章类型： Article，,卷期：2012年31-8] Efficient supply of new histones during DNA replication is critical to restore chromatin organization and maintain genome function. The histone chaperone anti-silencing function 1 (Asf1) serves a key function in providin... Organismal propagation in the absence of a functional telomerase pathway in Caenorhabditis elegans [作者：Lackner, DH; Raices, M; Maruyama, H; Haggblom, C; Karlseder, J,期刊：EMBO journal, 页码：2024-2033 , 文章类型： Article，,卷期：2012年31-8] To counteract replication-dependent telomere shortening most eukaryotic cells rely on the telomerase pathway, which is crucial for the maintenance of proliferative potential of germ and stem cell populations of multicell... RPA facilitates telomerase activity at chromosome ends in budding and fission yeasts [作者：Luciano, P; Coulon, S; Faure, V; Corda, Y; Bos, J; Brill, SJ; Gilson, E; Simon, MN; Geli, V,期刊：EMBO journal, 页码：2034-2046 , 文章类型： Article，,卷期：2012年31-8] In Saccharomyces cerevisiae, the telomerase complex binds to chromosome ends and is activated in late S-phase through a process coupled to the progression of the replication fork. Here, we show that the single-stranded D... Lysophospholipid presentation by CD1d and recognition by a human Natural Killer T-cell receptor [作者：Lopez-Sagaseta, J; Sibener, LV; Kung, JE; Gumperz, J; Adams, EJ,期刊：EMBO journal, 页码：2047-2059 , 文章类型： Article，,卷期：2012年31-8] Invariant Natural Killer T (iNKT) cells use highly restricted alpha beta Tcell receptors (TCRs) to probe the repertoire of lipids presented by CD1d molecules. Here, we describe our studies of lysophosphatidylcholine (LPC... s The demise of a TUDOR under stress opens a chromatin link to 53BP1 [作者：Stewart, GS,期刊：EMBO journal, 页码：1847-1849 , 文章类型： Editorial Material，,卷期：2012年31-8] The mechanisms that localise 53BP1 to sites of DNA double-strand breaks (DSBs) have remained elusive, despite this protein's key roles in DNA damage response signalling and repair processes. Recent studies, including the... CyclinD2 at the edge: splitting up cell fate [作者：Calegari, F,期刊：EMBO journal, 页码：1850-1852 , 文章类型： Editorial Material，,卷期：2012年31-8] Asymmetric cell division and cell cycle length are two fundamental mechanisms that influence the fate of neural stem cells during mammalian brain development. In this issue of The EMBO Journal, the team of Noriko Osumi p... Shaping the role of mitochondria in the pathogenesis of Huntington's disease [作者：Costa, V; Scorrano, L,期刊：EMBO journal, 页码：1853-1864 , 文章类型： Review，,卷期：2012年31-8] Intense research on the pathogenesis of Huntington's disease (HD), a genetic neurodegenerative disease caused by a polyglutamine expansion in the Huntingtin (Htt) protein, revealed multiple potential mechanisms, among wh... RNF8-and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites [作者：Mallette, FA; Mattiroli, F; Cui, GF; Young, LC; Hendzel, MJ; Mer, G; Sixma, TK; Richard, S,期刊：EMBO journal, 页码：1865-1878 , 文章类型： Article，,卷期：2012年31-8] In response to DNA damage, cells initiate complex signalling cascades leading to growth arrest and DNA repair. The recruitment of 53BP1 to damaged sites requires the activation of the ubiquitination cascade controlled by...