- Lrig1: a new master regulator of epithelial stem cells
[作者：Ordonez-Moran, P; Huelsken, J,期刊：EMBO journal, 页码：2064-2066 , 文章类型： Editorial Material，,卷期：2012年31-9]
- The intestine represents the most vigorously renewing, adult epithelial tissue that makes maintenance of its homeostasis a delicate balance between proliferation, cell cycle arrest, migration, differentiation, and cell d...
- Mechanisms regulating epidermal stem cells
[作者：Beck, B; Blanpain, C,期刊：EMBO journal, 页码：2067-2075 , 文章类型： Review，,卷期：2012年31-9]
- The skin epidermis contains different appendages such as the hair follicle and the sebaceous glands. Recent studies demonstrated that several types of stem cells (SCs) exist in different niches within the epidermis and m...
- Cohesin-SA1 deficiency drives aneuploidy and tumourigenesis in mice due to impaired replication of telomeres
[作者：Remeseiro, S; Cuadrado, A; Carretero, M; Martinez, P; Drosopoulos, WC; Canamero, M; Schildkraut, CL; Blasco, MA; Losada, A,期刊：EMBO journal, 页码：2076-2089 , 文章类型： Article，,卷期：2012年31-9]
- Cohesin is a protein complex originally identified for its role in sister chromatid cohesion, although increasing evidence portrays it also as a major organizer of interphase chromatin. Vertebrate cohesin consists of Smc...
- A unique role of cohesin-SA1 in gene regulation and development
[作者：Remeseiro, S; Cuadrado, A; Gomez-Lopez, G; Pisano, DG; Losada, A,期刊：EMBO journal, 页码：2090-2102 , 文章类型： Article，,卷期：2012年31-9]
- Vertebrates have two cohesin complexes that consist of Smc1, Smc3, Rad21/Scc1 and either SA1 or SA2, but their functional specificity is unclear. Mouse embryos lacking SA1 show developmental delay and die before birth. C...
- HIF1 alpha induced switch from bivalent to exclusively glycolytic metabolism during ESC-to-EpiSC/hESC transition
[作者：Zhou, WY; Choi, M; Margineantu, D; Margaretha, L; Hesson, J; Cavanaugh, C; Blau, CA; Horwitz, MS; Hockenbery, D; Ware, C; Ruohola-Baker, H,期刊：EMBO journal, 页码：2103-2116 , 文章类型： Article，,卷期：2012年31-9]
- The function of metabolic state in stemness is poorly understood. Mouse embryonic stem cells (ESC) and epiblast stem cells (EpiSC) are at distinct pluripotent states representing the inner cell mass (ICM) and epiblast em...
- Loss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in mice
[作者：Quiros, PM; Ramsay, AJ; Sala, D; Fernandez-Vizarra, E; Rodriguez, F; Peinado, JR; Fernandez-Garcia, MS; Vega, JA; Enriquez, JA; Zorzano, A; Lopez-Otin, C,期刊：EMBO journal, 页码：2117-2133 , 文章类型： Article，,卷期：2012年31-9]
- Mitochondria are dynamic subcellular organelles that convert nutrient intermediates into readily available energy equivalents. Optimal mitochondrial function is ensured by a highly evolved quality control system, coordin...
- Tightening of the ATP-binding sites induces the opening of P2X receptor channels
[作者：Jiang, R; Taly, A; Lemoine, D; Martz, A; Cunrath, O; Grutter, T,期刊：EMBO journal, 页码：2134-2143 , 文章类型： Article，,卷期：2012年31-9]
- The opening of ligand-gated ion channels in response to agonist binding is a fundamental process in biology. In ATP-gated P2X receptors, little is known about the molecular events that couple ATP binding to channel openi...
- Solution single-vesicle assay reveals PIP2-mediated sequential actions of synaptotagmin-1 on SNAREs
[作者：Kim, JY; Choi, BK; Choi, MG; Kim, SA; Lai, Y; Shin, YK; Lee, NK,期刊：EMBO journal, 页码：2144-2155 , 文章类型： Article，,卷期：2012年31-9]
- Synaptotagmin-1 (Syt1) is a major Ca2+ sensor for synchronous neurotransmitter release, which requires vesicle fusion mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors). Syt1 util...
- Munc18-1 mutations that strongly impair SNARE-complex binding support normal synaptic transmission
[作者：Meijer, M; Burkhardt, P; de Wit, H; Toonen, RF; Fasshauer, D; Verhage, M,期刊：EMBO journal, 页码：2156-2168 , 文章类型： Article，,卷期：2012年31-9]
- Synaptic transmission depends critically on the Sec1p/Munc18 protein Munc18-1, but it is unclear whether Munc18-1 primarily operates as a integral part of the fusion machinery or has a more upstream role in fusion comple...
- Mcm10 plays an essential role in origin DNA unwinding after loading of the CMG components
[作者：Kanke, M; Kodama, Y; Takahashi, TS; Nakagawa, T; Masukata, H,期刊：EMBO journal, 页码：2182-2194 , 文章类型： Article，,卷期：2012年31-9]
- The CMG complex composed of Mcm2-7, Cdc45 and GINS is postulated to be the eukaryotic replicative DNA helicase, whose activation requires sequential recruitment of replication proteins onto Mcm2-7. Current models suggest...
- Mcm10 associates with the loaded DNA helicase at replication origins and defines a novel step in its activation
[作者：van Deursen, F; Sengupta, S; De Piccoli, G; Sanchez-Diaz, A; Labib, K,期刊：EMBO journal, 页码：2195-2206 , 文章类型： Article，,卷期：2012年31-9]
- Mcm10 is essential for chromosome replication in eukaryotic cells and was previously thought to link the Mcm2-7 DNA helicase at replication forks to DNA polymerase alpha. Here, we show that yeast Mcm10 interacts preferen...
- EBV and human microRNAs co-target oncogenic and apoptotic viral and human genes during latency
[作者：Riley, KJ; Rabinowitz, GS; Yario, TA; Luna, JM; Darnell, RB; Steitz, JA,期刊：EMBO journal, 页码：2207-2221 , 文章类型： Article，,卷期：2012年31-9]
- Epstein-Barr virus (EBV) controls gene expression to transform human B cells and maintain viral latency. High-throughput sequencing and crosslinking immunoprecipitation (HITS-CLIP) identified mRNA targets of 44 EBV and 3...
- Crystal structure of Cwc2 reveals a novel architecture of a multipartite RNA-binding protein
[作者：Schmitzova, J; Rasche, N; Dybkov, O; Kramer, K; Fabrizio, P; Urlaub, H; Luhrmann, R; Pena, V,期刊：EMBO journal, 页码：2222-2234 , 文章类型： Article，,卷期：2012年31-9]
- The yeast splicing factor Cwc2 contacts several catalytically important RNA elements in the active spliceosome, suggesting that Cwc2 is involved in determining their spatial arrangement at the spliceosome's catalytic cen...
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