- Induced pluripotent stem cell-derived hepatocytes have the functional and proliferative capabilities needed for liver regeneration in mice
[作者：Espejel, S; Roll, GR; McLaughlin, KJ; Lee, AY; Zhang, JY; Laird, DJ; Okita, K; Yamanaka, S; Willenbring, H,期刊：Journal of clinical investigation, 页码：3120-3126 , 文章类型： Article，,卷期：2010年120-9]
- The ability to generate induced pluripotent stem (iPS) cells from a patient's somatic cells has provided a foundation for organ regeneration without the need for immune suppression. However, it has not been established t...
- Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells
[作者：Rashid, ST; Corbineau, S; Hannan, N; Marciniak, SJ; Miranda, E; Alexander, G; Huang-Doran, I; Griffin, J; Ahrlund-Richter, L; Skepper, J; Semple, R; Weber, A; Lomas, DA; Vallier, L,期刊：Journal of clinical investigation, 页码：3127-3136 , 文章类型： Article，,卷期：2010年120-9]
- Human induced pluripotent stem (iPS) cells hold great promise for advancements in developmental biology, cell-based therapy, and modeling of human disease. Here, we examined the use of human iPS cells for modeling inheri...
- Disease phenotype of a ferret CFTR-knockout model of cystic fibrosis
[作者：Sun, XS; Sui, HS; Fisher, JT; Yan, ZY; Liu, XM; Cho, HJ; Joo, NS; Zhang, YL; Zhou, WH; Yi, YL; Kinyon, JM; Lei-Butters, DC; Griffin, MA; Naumann, P; Luo, MH; Ascher, J; Wang, K; Frana, T; Wine, JJ; Meyerholz, DK; Engelhardt, JF,期刊：Journal of clinical investigation, 页码：3149-3160 , 文章类型： Article，,卷期：2010年120-9]
- Cystic fibrosis (CF) is a recessive disease that affects multiple organs. It is caused by mutations in CFTR. Animal modeling of this disease has been challenging, with species- and strain-specific differences in organ bi...
- Activated protein C targets CD8(+) dendritic cells to reduce the mortality of endotoxemia in mice
[作者：Kerschen, E; Hernandez, I; Zogg, M; Jia, SA; Hessner, MJ; Fernandez, JA; Griffin, JH; Huettner, CS; Castellino, FJ; Weiler, H,期刊：Journal of clinical investigation, 页码：3167-3178 , 文章类型： Article，,卷期：2010年120-9]
- Activated protein C (aPC) therapy reduces mortality in adult patients with severe sepsis. In mouse endotoxemia and sepsis models, mortality reduction requires the cell signaling function of aPC, mediated through protease...
- Anaplasma phagocytophilum induces Ixodes scapularis ticks to express an antifreeze glycoprotein gene that enhances their survival in the cold
[作者：Neelakanta, G; Sultana, H; Fish, D; Anderson, JF; Fikrig, E,期刊：Journal of clinical investigation, 页码：3179-3190 , 文章类型： Article，,卷期：2010年120-9]
- In the United States, Ixodes scapularis ticks overwinter in the Northeast and Upper Midwest and transmit the agent of human granulocytic anaplasmosis, Anaplasma phagocytophilum, among other pathogens. We now show that th...
- Reconstruction of the complete human cytomegalovirus genome in a BAC reveals RL13 to be a potent inhibitor of replication
[作者：Stanton, RJ; Baluchova, K; Dargan, DJ; Cunningham, C; Sheehy, O; Seirafian, S; McSharry, BP; Neale, ML; Davies, JA; Tomasec, P; Davison, AJ; Wilkinson, GWG,期刊：Journal of clinical investigation, 页码：3191-3208 , 文章类型： Article，,卷期：2010年120-9]
- Human cytomegalovirus (HCMV) in clinical material cannot replicate efficiently in vitro until it has adapted by mutation. Consequently, wild-type HCMV differ fundamentally from the passaged strains used for research. To ...
- Epigenetic basis for aberrant upregulation of autoantigen genes in humans with ANCA vasculitis
[作者：Ciavatta, DJ; Yang, J; Preston, GA; Badhwar, AK; Xiao, H; Hewins, P; Nester, CM; Pendergraft, WF; Magnuson, TR; Jennette, JC; Falk, RJ,期刊：Journal of clinical investigation, 页码：3209-3219 , 文章类型： Article，,卷期：2010年120-9]
- Antineutrophil cytoplasmic autoantibody (ANCA) causes vascular injury that leads to small-vessel vasculitis. Patients with ANCA aberrantly express neutrophil granule-encoding genes, including 2 that encode autoantigens: ...
- Animal and human antibodies to distinct Staphylococcus aureus antigens mutually neutralize opsonic killing and protection in mice
[作者：Skurnik, D; Merighi, M; Grout, M; Gadjeva, M; Maira-Litran, T; Ericsson, M; Goldmann, DA; Huang, SS; Datta, R; Lee, JC; Pier, GB,期刊：Journal of clinical investigation, 页码：3220-3233 , 文章类型： Article，,卷期：2010年120-9]
- New prophylactic approaches are needed to control infection with the Gram-positive bacterium Staphylococcus aureus, which is a major cause of nosocomial and community-acquired infections. To develop these, greater unders...
- An alphavirus vector overcomes the presence of neutralizing antibodies and elevated numbers of Tregs to induce immune responses in humans with advanced cancer
[作者：Morse, MA; Hobeika, AC; Osada, T; Berglund, P; Hubby, B; Negri, S; Niedzwiecki, D; Devi, GR; Burnett, BK; Clay, TM; Smith, J; Lyerly, HK,期刊：Journal of clinical investigation, 页码：3234-3241 , 文章类型： Article，,卷期：2010年120-9]
- Therapeutic anticancer vaccines are designed to boost patients' immune responses to tumors. One approach is to use a viral vector to deliver antigen to in situ DCs, which then activate tumor-specific T cell and antibody ...
- Vitamin D-3 attenuates Th2 responses to Aspergillus fumigatus mounted by CD4(+) T cells from cystic fibrosis patients with allergic bronchopulmonary aspergillosis
[作者：Kreindler, JL; Steele, C; Nguyen, N; Chan, YR; Pilewski, JM; Alcorn, JF; Vyas, YM; Aujla, SJ; Finelli, P; Blanchard, M; Zeigler, SF; Logar, A; Hartigan, E; Kurs-Lasky, M; Rockette, H; Ray, A; Kolls, JK,期刊：Journal of clinical investigation, 页码：3242-3254 , 文章类型： Article，,卷期：2010年120-9]
- Allergic bronchopulmonary aspergillosis (ABPA) is caused by a dominant Th2 immune response to antigens derived from the opportunistic mold Aspergillus, most commonly Aspergillus fumigatus. It occurs in 4%-15% of patients...
- Neurons derived from transplanted neural stem cells restore disrupted neuronal circuitry in a mouse model of spinal cord injury
[作者：Abematsu, M; Tsujimura, K; Yamano, M; Saito, M; Kohno, K; Kohyama, J; Namihira, M; Komiya, S; Nakashima, K,期刊：Journal of clinical investigation, 页码：3255-3266 , 文章类型： Article，,卷期：2010年120-9]
- The body's capacity to restore damaged neural networks in the injured CNS is severely limited. Although various treatment regimens can partially alleviate spinal cord injury (SCI), the mechanisms responsible for symptoma...
- Increased catecholamine secretion contributes to hypertension in TRPM4-deficient mice
[作者：Mathar, I; Vennekens, R; Meissner, M; Kees, F; Van der Mieren, G; Londono, JEC; Uhl, S; Voets, T; Hummel, B; van den Bergh, A; Herijgers, P; Nilius, B; Flockerzi, V; Schweda, F; Freichel, M,期刊：Journal of clinical investigation, 页码：3267-3279 , 文章类型： Article，,卷期：2010年120-9]
- Hypertension is an underlying risk factor for cardiovascular disease. Despite this, its pathogenesis remains unknown in most cases. Recently, the transient receptor potential (TRP) channel family was associated with the ...
- Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice
[作者：Biswas, PS; Gupta, S; Chang, E; Song, L; Stirzaker, RA; Liao, JK; Bhagat, G; Pernis, AB,期刊：Journal of clinical investigation, 页码：3280-3295 , 文章类型： Article，,卷期：2010年120-9]
- Deregulated production of IL-17 and IL-21 plays a key pathogenic role in many autoimmune disorders. A delineation of the mechanisms that underlie the inappropriate synthesis of IL-17 and IL-21 in autoimmune diseases can ...
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