- Ablation of C/EBP beta alleviates ER stress and pancreatic beta cell failure through the GRP78 chaperone in mice
[作者:Matsuda, T; Kido, Y; Asahara, S; Kaisho, T; Tanaka, T; Hashimoto, N; Shigeyama, Y; Takeda, A; Inoue, T; Shibutani, Y; Koyanagi, M; Hosooka, T; Matsumoto, M; Inoue, H; Uchida, T; Koike, M; Uchiyama, Y; Akira, S; Kasuga, M,期刊:Journal of clinical investigation, 页码:115-126 , 文章类型: Article,,卷期:2010年120-1]
- Pancreatic beta cell failure is thought to underlie the progression from glucose intolerance to overt diabetes, and ER stress is implicated in such beta cell dysfunction. We have now shown that the transcription factor C...
- The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5
[作者:Rouschop, KMA; van den Beucken, T; Dubois, L; Niessen, H; Bussink, J; Savelkouls, K; Keulers, T; Mujcic, H; Landuyt, W; Voncken, JW; Lambin, P; van der Kogel, AJ; Koritzinsky, M; Wouters, BG,期刊:Journal of clinical investigation, 页码:127-141 , 文章类型: Article,,卷期:2010年120-1]
- Tumor hypoxia is a common microenvironmental factor that adversely influences tumor phenotype and treatment response. Cellular adaptation to hypoxia occurs through multiple mechanisms, including activation of the unfolde...
- Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction
[作者:Samudio, I; Harmancey, R; Fiegl, M; Kantarjian, H; Konopleva, M; Korchin, B; Kaluarachchi, K; Bornmann, W; Duvvuri, S; Taegtmeyer, H; Andreeff, M,期刊:Journal of clinical investigation, 页码:142-156 , 文章类型: Article,,卷期:2010年120-1]
- The traditional view is that cancer cells predominately produce ATP by glycolysis, rather than by oxidation of energy-providing substrates. Mitochondrial uncoupling - the continuing reduction of oxygen without ATP synthe...
- BTLA mediates inhibition of human tumor-specific CD8(+) T cells that can be partially reversed by vaccination
[作者:Derre, L; Rivals, JP; Jandus, C; Pastor, S; Rimoldi, D; Romero, P; Michielin, O; Olive, D; Speiser, DE,期刊:Journal of clinical investigation, 页码:157-167 , 文章类型: Article,,卷期:2010年120-1]
- The function of antigen-specific CD8(+) T cells, which may protect against both infectious and malignant diseases, can be impaired by ligation of their inhibitory receptors, which include CTL-associated protein 4 (CTLA-4...
- CD27 sustains survival of CTLs in virus-infected nonlymphoid tissue in mice by inducing autocrine IL-2 production
[作者:Peperzak, V; Xiao, YL; Veraar, EAM; Borst, J,期刊:Journal of clinical investigation, 页码:168-178 , 文章类型: Article,,卷期:2010年120-1]
- Immunity to infections relies on clonal expansion of CD8(+) T cells, their maintenance as effector CTLs, and their selection into a memory population. These processes rely on delivery of survival signals to activated CD8...
- Lnk regulates integrin alpha IIb beta 3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo
[作者:Takizawa, H; Nishimura, S; Takayama, N; Oda, A; Nishikii, H; Morita, Y; Kakinuma, S; Yamazaki, S; Okamura, S; Tamura, N; Goto, S; Sawaguchi, A; Manabe, I; Takatsu, K; Nakauchi, H; Takaki, S; Eto, K,期刊:Journal of clinical investigation, 页码:179-190 , 文章类型: Article,,卷期:2010年120-1]
- The nature of the in vivo cellular events underlying thrombus formation mediated by platelet activation remains unclear because of the absence of a modality for analysis. Lymphocyte adaptor protein (Lnk; also known as Sh...
- Deletion of Fas in adipocytes relieves adipose tissue inflammation and hepatic manifestations of obesity in mice
[作者:Wueest, S; Rapold, RA; Schumann, DM; Rytka, JM; Schildknecht, A; Nov, O; Chervonsky, AV; Rudich, A; Schoenle, EJ; Donath, MY; Konrad, D,期刊:Journal of clinical investigation, 页码:191-202 , 文章类型: Article,,卷期:2010年120-1]
- Adipose tissue inflammation is linked to the pathogenesis of insulin resistance. In addition to exerting death-promoting effects, the death receptor Fas (also known as CD95) can activate inflammatory pathways in several ...
- Urea-induced ROS generation causes insulin resistance in mice with chronic renal failure
[作者:D'Apolito, M; Du, XL; Zong, HH; Catucci, A; Maiuri, L; Trivisano, T; Pettoello-Mantovani, M; Campanozzi, A; Raia, V; Pessin, JE; Brownlee, M; Giardino, I,期刊:Journal of clinical investigation, 页码:203-213 , 文章类型: Article,,卷期:2010年120-1]
- Although supraphysiological concentrations of urea are known to increase oxidative stress in cultured cells, it is generally thought that the elevated levels of urea in chronic renal failure patients have negligible toxi...
- CD20 deficiency in humans results in impaired T cell-independent antibody responses
[作者:Kuijpers, TW; Bende, RJ; Baars, PA; Grummels, A; Derks, IAM; Dolman, KM; Beaumont, T; Tedder, TF; van Noesel, CJM; Eldering, E; van Lier, RAW,期刊:Journal of clinical investigation, 页码:214-222 , 文章类型: Article,,卷期:2010年120-1]
- CD20 was the first B cell differentiation antigen identified, and CD20-specific mAbs are commonly used for the treatment of B cell malignancies and autoantibody-mediated autoimmune diseases. Despite this the role of CD20...
- Genetic and epigenetic silencing of SCARA5 may contribute to human hepatocellular carcinoma by activating FAK signaling
[作者:Huang, J; Zheng, DL; Qin, FS; Cheng, N; Chen, H; Wan, BB; Wang, YP; Xiao, HS; Han, ZG,期刊:Journal of clinical investigation, 页码:223-241 , 文章类型: Article,,卷期:2010年120-1]
- The epigenetic silencing of tumor suppressor genes is a crucial event during carcinogenesis and metastasis. Here, in a human genome-wide survey, we identified scavenger receptor class A, member 5 (SCARA5) as a candidate ...
- Cardiac mast cells cause atrial fibrillation through PDGF-A-mediated fibrosis in pressure-overloaded mouse hearts
[作者:Liao, CH; Akazawa, H; Tamagawa, M; Ito, K; Yasuda, N; Kudo, Y; Yamamoto, R; Ozasa, Y; Fujimoto, M; Wang, P; Nakauchi, H; Nakaya, H; Komuro, I,期刊:Journal of clinical investigation, 页码:242-253 , 文章类型: Article,,卷期:2010年120-1]
- Atrial fibrillation (AF) is a common arrhythmia that increases the risk of stroke and heart failure. Here, we have shown that mast cells, key mediators of allergic and immune responses, are critically involved in AF path...
- Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload
[作者:Takeda, N; Manabe, I; Uchino, Y; Eguchi, K; Matsumoto, S; Nishimura, S; Shindo, T; Sano, M; Otsu, K; Snider, P; Conway, SJ; Nagai, R,期刊:Journal of clinical investigation, 页码:254-265 , 文章类型: Article,,卷期:2010年120-1]
- Fibroblasts, which are the most numerous cell type in the heart, interact with cardiomyocytes in vitro and affect their function; however, they are considered to play a secondary role in cardiac hypertrophy and failure. ...
- Limited forward trafficking of connexin 43 reduces cell-cell coupling in stressed human and mouse myocardium
[作者:Smyth, JW; Hong, TT; Gao, DC; Vogan, JM; Jensen, BC; Fong, TS; Simpson, PC; Stainier, DYR; Chi, NC; Shaw, RM,期刊:Journal of clinical investigation, 页码:266-279 , 文章类型: Article,,卷期:2010年120-1]
- Gap junctions form electrical conduits between adjacent myocardial cells, permitting rapid spatial passage of the excitation current essential to each heartbeat. Arrhythmogenic decreases in gap junction coupling are a ch...
- Cardiac signaling genes exhibit unexpected sequence diversity in sporadic cardiomyopathy, revealing HSPB7 polymorphisms associated with disease
[作者:Matkovich, SJ; Van Booven, DJ; Hindes, A; Kang, MY; Druley, TE; Vallania, FLM; Mitra, RD; Reilly, MP; Cappola, TP; Dorn, GW,期刊:Journal of clinical investigation, 页码:280-289 , 文章类型: Article,,卷期:2010年120-1]
- Sporadic heart failure is thought to have a genetic component, but the contributing genetic events are poorly defined. Here, we used ultra-high-throughput resequencing of pooled DNAs to identify SNPs in 4 biologically re...
- TGF-beta 1-induced expression of human Mdm2 correlates with late-stage metastatic breast cancer
[作者:Araki, S; Eitel, JA; Batuello, CN; Bijangi-Vishehsaraei, K; Xie, XJ; Danielpour, D; Pollok, KE; Boothman, DA; Mayo, LD,期刊:Journal of clinical investigation, 页码:290-302 , 文章类型: Article,,卷期:2010年120-1]
- The E3 ubiquitin ligase human murine double minute (HDM2) is overexpressed in 40%-80% of late-stage metastatic cancers in the absence of gene amplification. Hdm2 regulates p53 stability via ubiquitination and has also be...
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