- Activated regulatory T cells are the major T cell type emigrating from the skin during a cutaneous immune response in mice
[作者:Tomura, M; Honda, T; Tanizaki, H; Otsuka, A; Egawa, G; Tokura, Y; Waldmann, H; Hori, S; Cyster, JG; Watanabe, T; Miyachi, Y; Kanagawa, O; Kabashima, K,期刊:Journal of clinical investigation, 页码:883-893 , 文章类型: Article,,卷期:2010年120-3]
- Tregs play an important role in protecting the skin from autoimmune attack. However, the extent of Treg trafficking between the skin and draining lymph nodes (DLNs) is unknown. We set out to investigate this using mice e...
- Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophages
[作者:Labadie, K; Larcher, T; Joubert, C; Mannioui, A; Delache, B; Brochard, P; Guigand, L; Dubreil, L; Lebon, P; Verrier, B; de Lamballerie, X; Suhrbier, A; Cherel, Y; Le Grand, R; Roques, P,期刊:Journal of clinical investigation, 页码:894-906 , 文章类型: Article,,卷期:2010年120-3]
- Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that induces in humans a disease characterized by fever, rash, and pain in muscles and joints. The recent emergence or reemergence of CHIKV in the Indian Ocean Isl...
- Comprehensive assessment of chemokine expression profiles by flow cytometry
[作者:Eberlein, J; Nguyen, TT; Victorino, F; Golden-Mason, L; Rosen, HR; Homann, D,期刊:Journal of clinical investigation, 页码:907-923 , 文章类型: Article,,卷期:2010年120-3]
- The chemokines are a large family of mainly secreted molecules involved in the regulation of numerous physiological and pathophysiological processes. Despite many years of investigation, the precise cellular sources of m...
- Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment
[作者:Bissig, KD; Wieland, SF; Tran, P; Isogawa, M; Le, TT; Chisari, FV; Verma, IM,期刊:Journal of clinical investigation, 页码:924-930 , 文章类型: Article,,卷期:2010年120-3]
- A paucity of versatile small animal models of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection has been an impediment to both furthering understanding of virus biology and testing antiviral therapies. We rec...
- Substance P stimulates human airway submucosal gland secretion mainly via a CFTR-dependent process (vol 119, pg 1189, 2009)
[作者:Choi, JY; Khansaheb, M; Joo, NS; Krouse, ME; Robbins, RC; Weill, D; Wine, JJ,期刊:Journal of clinical investigation, 页码:931-932 , 文章类型: Correction,,卷期:2010年120-3]
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- FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice (vol 120, pg 357, 2010)
[作者:Rached, MT; Kode, A; Silva, BC; Jung, DY; Gray, S; Ong, H; Paik, JH; DePinho, RA; Kim, JK; Karsenty, G; Kousteni, S,期刊:Journal of clinical investigation, 页码:932-932 , 文章类型: Correction,,卷期:2010年120-3]
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- Urea-induced ROS generation causes insulin resistance in mice with chronic renal failure (vol 120, pg 203, 2010)
[作者:D'Apolito, M; Du, XL; Zong, HH; Catucci, A; Maiuri, L; Trivisano, T; Pettoello-Mantovani, M; Campanozzi, A; Raia, V; Pessin, JE; Brownlee, M; Giardino, I,期刊:Journal of clinical investigation, 页码:932-932 , 文章类型: Correction,,卷期:2010年120-3]
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- New horizons for studying human hepatotropic infections
[作者:de Jong, YP; Rice, CM; Ploss, A,期刊:Journal of clinical investigation, 页码:650-653 , 文章类型: Editorial Material,,卷期:2010年120-3]
- The liver serves as a target organ for several important pathogens, including hepatitis B and C viruses (HBV and HCV, respectively) and the human malaria parasites, all of which represent serious global health problems. ...
- A nonhuman primate model of chikungunya disease
[作者:Higgs, S; Ziegler, SA,期刊:Journal of clinical investigation, 页码:657-660 , 文章类型: Editorial Material,,卷期:2010年120-3]
- Chikungunya disease is a severely debilitating, mosquito-borne, viral illness that has reached epidemic proportions in Africa, Asia, and the islands of the Indian Ocean. A mutation enhancing the ability of the chikunguny...
- CD99 inhibits neural differentiation of human Ewing sarcoma cells and thereby contributes to oncogenesis
[作者:Rocchi, A; Manara, MC; Sciandra, M; Zambelli, D; Nardi, F; Nicoletti, G; Garofalo, C; Meschini, S; Astolfi, A; Colombo, MP; Lessnick, SL; Picci, P; Scotlandi, K,期刊:Journal of clinical investigation, 页码:668-680 , 文章类型: Article,,卷期:2010年120-3]
- Ewing sarcoma (EWS) is an aggressive bone tumor of uncertain cellular origin. CD99 is a membrane protein that is expressed in most cases of EWS, although its function in the disease is unknown. Here we have shown that en...
- A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis
[作者:Alimonti, A; Nardella, C; Chen, ZB; Clohessy, JG; Carracedo, A; Trotman, LC; Cheng, K; Varmeh, S; Kozma, SC; Thomas, G; Rosivatz, E; Woscholski, R; Cognetti, F; Scher, HI; Pandolfi, PP,期刊:Journal of clinical investigation, 页码:681-693 , 文章类型: Article,,卷期:2010年120-3]
- Irreversible cell growth arrest, a process termed cellular senescence, is emerging as an intrinsic tumor suppressive mechanism. Oncogene-induced senescence is thought to be invariably preceded by hyperproliferation, aber...
- Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice
[作者:Kioi, M; Vogel, H; Schultz, G; Hoffman, RM; Harsh, GR; Brown, JM,期刊:Journal of clinical investigation, 页码:694-705 , 文章类型: Article,,卷期:2010年120-3]
- Despite the high doses of radiation delivered in the treatment of patients with glioblastoma multiforme (GBM), the tumors invariably recur within the irradiation field, resulting in a low cure rate. Understanding the mec...
- Urolithiasis and hepatotoxicity are linked to the anion transporter Sat1 in mice
[作者:Dawson, PA; Russell, CS; Lee, S; McLeay, SC; van Dongen, JM; Cowley, DM; Clarke, LA; Markovich, D,期刊:Journal of clinical investigation, 页码:706-712 , 文章类型: Article,,卷期:2010年120-3]
- Urolithiasis, a condition in which stones are present in the urinary system, including the kidneys and bladder, is a poorly understood yet common disorder worldwide that leads to significant health care costs, morbidity,...
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